Comparative Effects of Photodynamic Therapy mediated by Curcumin on Standard and Clinical Isolate of Streptococcus mutans

Abstract

Alternative antimicrobial approaches, as photodynamic therapy, should be encouraged due to optimal results against cariogenic bacteria aiming to prevent or treat dental caries.

Randomizedin vivoevaluation of photodynamic antimicrobial chemotherapy on deciduous carious dentin

“…A tendency for this to be achieved in the PACT groups was observed; however, the reduction did not differ statistically from that of the control group. This is in agreement with studies conducted by Teixeira et al, 29 who were unable to demonstrate the antimicrobial effect of PACT in bacteria present in oral biofilm, and by Tonon et al, 20 who found only a discrete bacterial reduction in a clinical isolate strain of S. mutans. Bacteria have different behaviors when treated in planktonic cultures, in biofilms, and in carious dentin.…”

“…dentin. [11][12][13][14][15][16][17][18][19][20] The results of the present study demonstrated that PACT reduced the number of all the microorganisms tested after each treatment, except for S. sobrinus; however, for the LED and low-power laser parameters used, no differences could be found among the groups. The classic treatment for deep caries lesions, as was performed in our control group, is to remove the infected dentin, clean the remaining affected tissue, and seal the cavity with a restorative material.…”

“…Bacteria have different behaviors when treated in planktonic cultures, in biofilms, and in carious dentin. 15,17,20 PACT is less prone to work in biofilms or in the carious dentin matrix due to the limited penetration of the photosensitizing agent into this surface and the deficient light propagation through the demineralized tissues. 18,19,30 A relevant in vivo study conducted with 26 young adult patients with deep caries in permanent molars, by using methylene blue as the photosensitive agent and lowpower red laser (InGaAIP λ ¼ 660 nm, 100 mW, 320 J∕cm 2 , 90 s, 9 J), was able to show a modest reduction in microorganisms (1 log 10 ), 14 however, differing from the high values achieved in in vitro or in situ studies.…”

“…11 This has also been observed in different studies using dentin collagen matrix, in vitro bovine carious dentin, in vitro human carious dentin, ex vivo carious dentin, and in vivo carious dentin. [13][14][15][16][17][18][19][20] If the microorganisms associated with dental caries could be reduced, in vivo, by PACT, the results could be very positive for conservative dentistry, since it does not imply removal of the affected dentin, thereby reducing the risk of pulp exposure, and can thus be considered less traumatic treatment for children. 10 Therefore, the aim of this study was to test, in vivo, two PACT protocols in the treatment of deep caries lesions in primary teeth by means of microbiological and clinical evaluations.…”

Effect of the antimicrobial photodynamic therapy on microorganism reduction in deep caries lesions: a systematic review and meta-analysis

“…18,12,19 aPDT is effective in killing oral microorganisms present in dentine caries that are produced in situ and in vitro and may be useful in minimally invasive dentistry. 20,21 Assuming that the in vitro and in situ techniques are effective, we suggest the following question: Is aPDT an effective coadjuvant therapy to reduce microorganisms in deep carious lesions?…”