Comparative  effects of lidocaine and esmolol in attenuating the hemodynamic response to laryngoscopy and intubation

Koju, Ram Bhakta; Dongol, Yashad

doi:10.3126/jssn.v17i2.17144

Cited by 3 publications

(2 citation statements)

References 13 publications

(22 reference statements)

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“…17 Many studies have been done to prevent this rise in hemodynamic parameter using different stress blunting drugs. 18 Paracetamol, magnesium sulfate, and lignocaine are commonly available used drugs in operation room. These drugs have been used individually in attenuation of pressure response to laryngoscopy and intubation in intraoperative period.…”

Section: Discussionmentioning

confidence: 99%

Effect of pre-emptive intravenous paracetamol, magnesium sulfate, and lignocaine on hemodynamic variables during perioperative period in pre-eclampsia patients scheduled for lower segment cesarean section under general anesthesia: A prospective randomized study

Kothari¹,

Bansal²,

Sunny³

2022

Asian J Med Sci

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Background: Hemodynamic alterations during general anesthesia with endotracheal intubation are due to stimulation of the sympathetic nervous system and catecholamine release. Therefore, it is important to attenuate these responses in pre-eclampsia patients who are already under stress. Aims and Objectives: The present study aimed to evaluate the combined efficacy of paracetamol, magnesium sulfate, and lignocaine in attenuating hemodynamic responses during intubation and perioperative period. Materials and Methods: Eighty ASA II pre-eclampsia patients were randomly divided into two groups. Group PLM received intravenous infusion of paracetamol (1 g) and magnesium sulfate (30 mg/kg) in 100 ml normal saline and IV bolus Inj. lignocaine (1.5 mg/kg) 15 min before induction. Group C received only IV infusion of 100 ml normal saline. Pulse rate (PR), blood pressure (BP), and oxygen saturation were measured at various time intervals up to 40 min of delivery of baby and in up to 240 min in post-operative period. Post-operative visual analog score (VAS) and the time for first rescue analgesia (TRA I) were recorded. Results: Demographic and baseline hemodynamic parameters were comparable in both groups (P>0.05). Changes in PR and BP during laryngoscopy, intubation, and perioperative period were significantly lesser in Group PLM as compared to Group C (P<0.05). The post-operative VAS score was significantly lower whereas TRA I was significantly longer in Group PLM than in Group C at all measuring times (P<0.05). Conclusion: Combination of paracetamol, magnesium sulfate, and lignocaine attenuates hemodynamic responses during laryngoscopy, intubation, and perioperative period along with prolonged post-operative analgesia in cesarean section under general anesthesia in pre-eclampsia patients.

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Section: Discussionmentioning

confidence: 99%

Effect of pre-emptive intravenous paracetamol, magnesium sulfate, and lignocaine on hemodynamic variables during perioperative period in pre-eclampsia patients scheduled for lower segment cesarean section under general anesthesia: A prospective randomized study

Kothari¹,

Bansal²,

Sunny³

2022

Asian J Med Sci

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“…Dexmedetomidine at a dose of 0.5 mcg/kg as 10-min infusion was administered prior to induction of general anaesthesia attenuates the sympathetic response to laryngoscopy and intubation in patients undergoing myocardial revascularization. Koju RB et al; [11] observed that there was an increase in systolic blood pressure, diastolic blood pressure, heart rate were significantly lower (p<0.05) in esmol group when compared to lidocaine and placebo group but there was no statistical significance (P>0.05) between control and lidocaine group after laryngoscopy and intubation.…”

Section: Discussionmentioning

confidence: 94%

Attenuation of hypertensive response with esmolol and labetalol in low doses in orotrachealintubation A comparative study

Kumar¹,

Selvarju²

2018

APJHS

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Background:The golden standard is rigid laryngoscopy and tracheal intubation in airway management. Aim: To study efficacy in stress response prevention on laryngoscopy and intubation and to study hemodynamic parameters intraoperatively. Materials and Methods: This study was a prospective, randomised, double blinded study which was conducted .Results: In both the study groups had similar demographicpro file. During laryngoscopy and intubation, esmolol and labetalol showed rise in heart rate, systolic blood pressure and RPP, whereas the values for MAP and DBP was not statistically significant difference. Conclusion: Labetalol is more effective when compared to esmolol in attenuating the sympathomimetic effect of laryngoscopy and intubation in lower doses.

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A Comparative Study of the Efficacy of Intravenous Paracetamol and Dexmedetomidine on Peri Operative Hemodynamics and Post Operative Analgesia for Patients Undergoing Laparoscopic Surgery

Goswami

Goel

Patel

et al. 2023

IJAR

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Perioperative hemodynamic instability is one of the known complication ofLaproscopic surgeries. CO2 insufation causes increased abdominal pressure and hypercapnia which will contribute to undesirable hemodynamic changes. Dexmedetomidine when administered as a loading dose causes sedative , hypnotic, anxiolytic, analgesic and sympatholytic effect. In ths study 60 Patients were randomised in two groups 30 each . Group 1/ Group P recieved 1gm paracetamol diluted in 100 ml 0.9% Normal saline IV over 10 minutes before induction. Group 2/Group D Bolus -1mcg/ kg diluted in 100 ml 0.9% Normal saline IV over 10 minutes before induction. Perioperative Hemodynamic parameters , post operative analgesia were compared. Increase in heart rate , blood pressure were found to be more in Group 1/Group P compared to Group 2/ Group 2/ Group D. Patients in both groups had moderated pain postoperatively and requires rescue analagesia after extubation. We observed the use of Dexmedetomidine is very effective in managing Perioperative Hemodynamic instability when compared to paracetamol

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Comparative effects of lidocaine and esmolol in attenuating the hemodynamic response to laryngoscopy and intubation

Cited by 3 publications

References 13 publications

Effect of pre-emptive intravenous paracetamol, magnesium sulfate, and lignocaine on hemodynamic variables during perioperative period in pre-eclampsia patients scheduled for lower segment cesarean section under general anesthesia: A prospective randomized study

Effect of pre-emptive intravenous paracetamol, magnesium sulfate, and lignocaine on hemodynamic variables during perioperative period in pre-eclampsia patients scheduled for lower segment cesarean section under general anesthesia: A prospective randomized study

Attenuation of hypertensive response with esmolol and labetalol in low doses in orotrachealintubation A comparative study

A Comparative Study of the Efficacy of Intravenous Paracetamol and Dexmedetomidine on Peri Operative Hemodynamics and Post Operative Analgesia for Patients Undergoing Laparoscopic Surgery

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