Comparative effects of ionic and nonionic contrast materials on indexes of isovolumic contraction and relaxation in humans

Mancini, G.B.John; Atwood, J E; Bhargava, Valmik; Slutsky, Robert A.; Grover, Maleah; Higgins, Charles B.

doi:10.1016/0002-9149(84)90717-3

Cited by 28 publications

(12 citation statements)

References 30 publications

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“…Our study shows that the ionic ioxaglate reduced this variable more than the non-ionic contrast media. These results are in accordance with previous studies (11,18,22). However, peak negative LV dP/dt is reduced by a fall in systolic pressure (8).…”

Section: Discussionsupporting

confidence: 94%

“…The reproducibility and the absence of fatal arrhythmias have made this model suitable for the study of cardiac toxicity of contrast media. Our finding that iohexol did not depress myocardial function, even in the presence of already depressed myocardial function, is in accordance with previous studies with different non-ionic monomeric contrast media (6,9,11,13,18). Ioxaglate depressed myocardial function to a greater extent after than before LV heart failure was induced.…”

Section: Discussionsupporting

confidence: 93%

“…Previously.both ionic and non-ionic contrast media have been shown to increase the T using zero asymptote for calculation (18). But several studies have emphasized that a variable asymptote should be used to avoid changes in T due to shifts in the LV pressure curve (5).…”

Section: Discussionmentioning

confidence: 99%

“…The ionic contrast medium, ioxaglate, has been shown to induce transient depression of myocardial function (1 3,33). Different non-ionic monomeric contrast media such as iohexol, iopamidol and metrizamide, on the other hand, have been shown to increase myocardial inotropy in most studies in dogs and humans, and also during depressed myocardial function (6, 9, 11, 13,18). Recently, a new non-ionic, dimeric contrast medium, iodixanol, has been developed.…”

mentioning

confidence: 99%

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Left Ventricular Systolic and Diastolic Function during Coronary Arteriography before and after Acute Left Ventricular Failure in Dogs

Kløw¹,

Mortensen²,

Refsum³

1991

Acta Radiol

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Left Ventricular Systolic and Diastolic Function during Coronary Arteriography before and after Acute Left Ventricular Failure in Dogs

Kløw¹,

Mortensen²,

Refsum³

1991

Acta Radiol

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“…Another approach to this problem has been the use of nonionic contrast media. Clinical studies have shown decreased patient toxicity, lesser alterations of myocardial contractility, relaxation, hemodynamics, and coronary blood flow, and absence of induced hypocalcemia and hypokalemia [26,28]. The use of nonionic agents may also reduce patient discomfort during injection and therefore, in turn, reduce patient motion [29].…”

Section: Contrast Administrationmentioning

confidence: 99%

Left ventricular imaging by digital subtraction angiography

Vogel

1988

Int J Cardiac Imag

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Digital radiography is a rapidly developing new approach to cardiovascular imaging that converts radiographic and fluoroscopic video images into digital format for subsequent image enhancement analysis, and storage. Left ventriculography can be performed by this method using either intravenous or low-dose intraventricular contrast administration. Advantages over standard radiography include reduced radiation and contrast medium burden, visualization of very low contrast medium concentrations, and an image format that can be directly analyzed by quantitative techniques. As these cardiac applications are developed and improved archiving is implemented, it is likely that the digital left ventriculography will replace standard cardiac angiography.

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Hemodynamic effects of iodixanol and iohexol during ventriculography in patients with compromised left ventricular function

Bergstra

Dijk

Brekke³

et al. 2000

Cathet. Cardiovasc. Intervent.

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A crossover study was performed to compare the hemodynamic effects of the iso-osmolar contrast agent iodixanol (Visipaque) 320 mg I/ml to those of the low-osmolar iohexol (Omnipaque) 350 mg I/ml. The main hypothesis was that iodixanol and iohexol would affect left ventricular end-diastolic pressure (LVEDP) to different degrees. In 48 patients with reduced cardiac function (mean ejection fraction 33. 4%), one ventricular injection was performed with each contrast medium. Ventricular, aortic and right atrial pressures and heart rate were measured continuously. Cardiac output (using Fick's principle) and systemic vascular resistance were calculated. LVEDP increased with both agents, but significantly less after iodixanol than after iohexol (P < 0.01), also in subgroups of patients in whom baseline LVEDP was severely increased and in whom 3-vessel disease was present. Immediate changes in variables reflecting vasodilatation were similar with both agents. In conclusion, both contrast agents influenced hemodynamics during ventriculography, but iodixanol had significantly less influence on LVEDP than did iohexol.

show abstract

Comparative effects of ionic and nonionic contrast materials on indexes of isovolumic contraction and relaxation in humans

Cited by 28 publications

References 30 publications

Left Ventricular Systolic and Diastolic Function during Coronary Arteriography before and after Acute Left Ventricular Failure in Dogs

Left Ventricular Systolic and Diastolic Function during Coronary Arteriography before and after Acute Left Ventricular Failure in Dogs

Left ventricular imaging by digital subtraction angiography

Hemodynamic effects of iodixanol and iohexol during ventriculography in patients with compromised left ventricular function

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