Comparative effects of in vitro ischemia on contractile responses of mouse and rat bladders to various forms of stimulation

Whitbeck, Catherine; Sourial, Michael; Sourial, Mariette; Levin, Robert M.

doi:10.1016/j.urology.2005.11.016

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…45,46 Such stores may enable anaerobic muscle function and prevent ischemic damage. 44,47,48 Measurements in live animals support the idea that a high bladder pressure can reduce the blood flow in the bladder wall. In pigs the blood flow decreased when detrusor pressure exceeded 10 cm H 2 O 43 and stopped at pressures over 41 cm H 2 O.…”

Section: Discussionmentioning

confidence: 87%

Potential for recovery in bladder function after removing a urethral obstruction

Wolffenbuttel

Jong

Scheepe

et al. 2008

Neurourology and Urodynamics

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Section: Discussionmentioning

confidence: 87%

Potential for recovery in bladder function after removing a urethral obstruction

Wolffenbuttel

Jong

Scheepe

et al. 2008

Neurourology and Urodynamics

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“…The protective effects of CoQ and aLA coadministration on bladder tissue were explored using two in vitro models of oxidative damage to the male rabbit bladder: (1) hydrogen peroxide model induces damage by direct oxidation of the isolated bladder strips [25] and (2) in vitro ischemia-reperfusion (I/R) model stimulated by anoxia, perfusion with nitrogen, and glucose starvation followed by oxygenated buffer with glucose [26,27]. Ischemia and reperfusion cause contractile dysfunction by the generation of free radicals and the subsequent oxidative damage to the smooth muscle.…”

Section: Discussionmentioning

confidence: 99%

Differential effects of coenzyme Q10 and α-lipoic acid on two models of in vitro oxidative damage to the rabbit urinary bladder

Schuler

Leggett

et al. 2010

Int Urol Nephrol

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In vivo measurement of bladder wall oxygen saturation using optical spectroscopy

Amelink

Kok

Sterenborg

et al. 2011

Journal of Biophotonics

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Current diagnosis, follow-up and treatment of patients suffering from bladder dysfunction are mainly symptom-targeted. A recently recognized cause of continuing bladder function loss is a deteriorated bladder microvasculature. Incorporating this aspect into the clinical diagnostic toolbox may improve treatment results. Recent developments in the field of optical spectroscopy now allow for non-invasive measurement of microvascular blood oxygen saturation in living tissue. We have recently reported pre-clinical data that show that this marker can be successfully measured in an animal bladder. In the animal model the marker differentiated bladders with loss of function from those with normal function. In the present paper, we report on the first in vivo measurement of this marker in the human bladder, as proof of principle, in the muscle of bladders with a normal function.

show abstract

Comparative effects of in vitro ischemia on contractile responses of mouse and rat bladders to various forms of stimulation

Cited by 3 publications

References 20 publications

Potential for recovery in bladder function after removing a urethral obstruction

Potential for recovery in bladder function after removing a urethral obstruction

Differential effects of coenzyme Q10 and α-lipoic acid on two models of in vitro oxidative damage to the rabbit urinary bladder

In vivo measurement of bladder wall oxygen saturation using optical spectroscopy

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