Comparative effects of genistein and bisphenol A on non-alcoholic fatty liver disease in laying hens

Gao, Xiaona; Liu, Shuhui; Ding, Chenchen; Miao, Yufan; Gao, Zhangshan; Li, Mengcong; Fan, Wentao; Tang, Zhihui; Mhlambi, Nobuhle Hyacinth; Yan, Liping; Song, Suquan

doi:10.1016/j.envpol.2021.117795

Cited by 20 publications

(20 citation statements)

References 48 publications

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“…Further, this demonstrates that exposure to multiple adverse factors during the perinatal period has a more profound impact than exposure to a single adverse factor ( Hsu et al, 2019 ). Moreover, patrilineal female mice, as well as matrilineal female and male mice, showed increased serum insulin levels and insulin resistance, which is consistent with previous reports that BPA or HFD exposure can cause insulin resistance ( Naville et al, 2019 ; Farrugia et al, 2021 ; Gao et al, 2021 ; Huang et al, 2021 ; Yang et al, 2021 ). This may in turn contribute to metabolic- and cardiovascular-related phenotypic changes.…”

Section: Discussionsupporting

confidence: 91%

Perinatal Combinational Exposure to Bisphenol A and a High-Fat Diet Contributes to Transgenerational Dysregulation of Cardiovascular and Metabolic Systems in Mice

Liu

Liao

Huang

et al. 2022

Front. Cell Dev. Biol.

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Both bisphenol A (BPA) and high-fat diet (HFD) exert unfavorable effects on animals and humans; moreover, they could affect the health of their offspring. BPA and HFD often coexist in modern lifestyles; however, the long-term effects of simultaneous exposure of mothers to BPA and HFD during the perinatal period on the cardiovascular and metabolic systems of the offspring remain unclear. This study aimed to examine the effect of simultaneous exposure of mothers to BPA and HFD on the risk of metabolic and cardiovascular abnormalities in offspring. Institute of Cancer Research female mice (F0) were exposed to BPA and fed with HFD before and during gestation until the end of lactation. F0 mice were mated with untreated males to produce the first generation (F1); subsequently, adult F1 males/females were mated with normal females/males to produce the second generation (F2). Combined maternal exposure to BPA and HFD caused myocardial hypertrophy and aortic tunica media thickening as well as increased the cross-sectional area of cardiomyocytes and blood pressure in the matrilineal F2 generation. These cardiovascular changes might be associated with reduced endothelial nitric oxide synthase (eNOS) levels. The patrilineal female F2 was more likely to be obese than the patrilineal male F2. Re-feeding with a HFD showed a more significant weight gain and reduced energy expenditure. However, the aforementioned effects were not observed with exposure to HFD or BPA alone during the perinatal period. Our findings suggest that perinatal combinational exposure to BPA and HFD could cause metabolic and cardiovascular disorders in the offspring, Further, our findings demonstrate that the synergistic effects of HFD and BPA could be transmitted to future generations in a sex-dependent manner.

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Section: Discussionsupporting

confidence: 91%

Perinatal Combinational Exposure to Bisphenol A and a High-Fat Diet Contributes to Transgenerational Dysregulation of Cardiovascular and Metabolic Systems in Mice

Liu

Liao

Huang

et al. 2022

Front. Cell Dev. Biol.

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“…Researchers found that hepatic hemorrhage and hepatomegaly occur in unhealthy liver of hens ( Lin et al, 2021 ). Moreover, Gao et al (2021) reported that more lipid accumulation was observed in the brown livers in hens compared to the dull red livers. Previous studies demonstrated that dietary supplemented with additives such as plant polysaccharide, polyphenols and flavonoids could alleviate hepatic structure damage and color changes in hens caused by liver dysfunction ( Wang et al, 2020b ; Gao et al, 2021 ; Miao et al, 2021 ) etc.…”

Section: Discussionmentioning

confidence: 99%

Dietary naringin supplementation on hepatic yolk precursors formation and antioxidant capacity of Three-Yellow breeder hens during the late laying period

Hou

et al. 2023

Poultry Science

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“…CTP1 is the rate-limiting enzyme of fatty acid oxidation, which regulates the entry progress of fatty acid into mitochondria. Gao et al reported that CPT1 was significantly down-regulated in the liver of 450-day-old Hy-Line Brown laying hens feeding with HELP for 90 d ( Gao et al, 2021 ). However, no significance of CTP1 was observed in the present study, which might be caused by animal age, the HELP consumption time and the metabolic energy provided by the diets.…”

Section: Discussionmentioning

confidence: 99%

Quantitative lipidomics reveals lipid perturbation in the liver of fatty liver hemorrhagic syndrome in laying hens

You

Zhang²,

Shen³

et al. 2023

Poultry Science

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Comparative effects of genistein and bisphenol A on non-alcoholic fatty liver disease in laying hens

Cited by 20 publications

References 48 publications

Perinatal Combinational Exposure to Bisphenol A and a High-Fat Diet Contributes to Transgenerational Dysregulation of Cardiovascular and Metabolic Systems in Mice

Perinatal Combinational Exposure to Bisphenol A and a High-Fat Diet Contributes to Transgenerational Dysregulation of Cardiovascular and Metabolic Systems in Mice

Dietary naringin supplementation on hepatic yolk precursors formation and antioxidant capacity of Three-Yellow breeder hens during the late laying period

Quantitative lipidomics reveals lipid perturbation in the liver of fatty liver hemorrhagic syndrome in laying hens

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