Quantitative lipidomics reveals lipid perturbation in the liver of fatty liver hemorrhagic syndrome in laying hens

You, Manhua; Zhang, Shaobo; Shen, Yizhao; Zhao, Xiao; Chen, Ligong; Liu, Juxiang; Ma, Ning

doi:10.1016/j.psj.2022.102352

Cited by 11 publications

(9 citation statements)

References 41 publications

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“…In this study, the overall abundance of TG in the differential lipids were upregulated in the egg yolk ( Supplementary Figure 3 A). Compared to the basal diet, the HELP diet has more amount of soybean oil, which have abundant PUFA ( You et al, 2023 ). PUFA can significantly promoted TG content in the liver, which affect lipid synthesis, lipoprotein secretion and the composition of egg yolk lipids ( Kawano and Cohen, 2013 ; Nii et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

“…It is an intermediate product of lipid metabolism, which is converted into TG under the action of diglyceride acyltransferase ( Greene et al, 2015 ). FLHS enhances the activity of diglyceride acyltransferase, resulting in an increase of TG content in the liver ( You et al, 2023 ). The upregulated TG in the liver is transported to the egg yolk, which might be the reasons for the increase of TG abundance in egg yolk.…”

Section: Discussionmentioning

confidence: 99%

“…All the laying hens were adjusted for 2 wk before the experiment. The FLHS and control groups respectively received the high-energy low-protein ( HELP ) diet and basal diet for 8 wk ( You et al, 2023 ). The compositions of the basal and HELP diets are provided in the Supplementary Table 1 .…”

Section: Methodsmentioning

confidence: 99%

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Quantitative lipidomics reveals the changes of lipids and antioxidant capacity in egg yolk from laying hens with fatty liver hemorrhagic syndrome

Guo,

Zhang,

You

et al. 2024

Poultry Science

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Quantitative lipidomics reveals the changes of lipids and antioxidant capacity in egg yolk from laying hens with fatty liver hemorrhagic syndrome

Guo,

Zhang,

You

et al. 2024

Poultry Science

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“…Lipid accumulated excessively in the liver cells is a typical pathological character in laying hens with FLHS [ 12 , 70 , 71 ]. Excessive lipid storage in the hepatocytes (fatty liver) accelerates β-oxidation, increasing ROS concentrations (a class of undesired side products in cellular electron transfer reaction during nutrient metabolism) [ 72 , 73 , 74 ].…”

Section: Molecular Mechanism Of Osteocalcin In Flhs Chickensmentioning

confidence: 99%

“…Excessive FFAs produce harmful ROS with lipotoxicity in hepatocytes, leading to mitochondria function defection and decrease in insulin secretion [ 85 ]. FFAs also increase inflammation and impair insulin signaling through pro-inflammatory cytokines, such as tumor necrosis factor—alpha (TNFα) and IL-6, which are up-regulated in FLHS chickens [ 12 , 62 , 70 ]. IL-6 has been identified as a key DEGs in HELP-diet chickens, increasing JNK signaling pathway and suppressing cytokine signaling 3 (SOCS 3) [ 62 ].…”

Section: Molecular Mechanism Of Osteocalcin In Flhs Chickensmentioning

confidence: 99%

Osteocalcin and Its Potential Functions for Preventing Fatty Liver Hemorrhagic Syndrome in Poultry

Zhang

Jiang

et al. 2023

Animals

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Osteocalcin (OCN) is synthesized and secreted by differentiating osteoblasts. In addition to its role in bone, OCN acts as a hormone in the pancreas, liver, muscle, fat, and other organs to regulate multiple pathophysiological processes including glucose homeostasis and adipic acid metabolism. Fat metabolic disorder, such as excessive fat buildup, is related to non-alcoholic fatty liver disease (NAFLD) in humans. Similarly, fatty liver hemorrhage syndrome (FLHS) is a metabolic disease in laying hens, resulting from lipid accumulation in hepatocytes. FLHS affects hen health with significant impact on poultry egg production. Many studies have proposed that OCN has protective function in mammalian NAFLD, but its function in chicken FLHS and related mechanism have not been completely clarified. Recently, we have revealed that OCN prevents laying hens from FLHS through regulating the JNK pathway, and some pathways related to the disease progression have been identified through both in vivo and vitro investigations. In this view, we discussed the current findings for predicting the strategy for using OCN to prevent or reduce FLHS impact on poultry production.

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Development of fatty liver disease model using high cholesterol and low choline diet in white leghorn chickens

Yadav,

Boley,

Khatiwada

et al. 2024

Vet Res Commun

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Nonalcoholic fatty liver disease (NAFLD), which shows similar symptoms as fatty liver hemorrhage syndrome (FLHS) in chickens, is the most common cause of chronic liver disease and cancer in humans. NAFLD patients and FLHS in chickens have demonstrated severe liver disorders when infected by emerging strains of human hepatitis E virus (HEV) and avian HEV, respectively. We sought to develop a fatty liver disease chicken model by altering the diet of 3-week-old white leghorn chickens. The high cholesterol, and low choline (HCLC) diet included 7.6% fat with additional 2% cholesterol and 800 mg/kg choline in comparison to 5.3% fat, and 1,300 mg/kg choline in the regular diet. Our diet induced fatty liver avian model successfully recapitulates the clinical features seen during NAFLD in humans and FLHS in chickens, including hyperlipidemia and hepatic steatosis, as indicated by significantly higher serum triglycerides, serum cholesterol, liver triglycerides, cholesterol, and fatty acids. By developing this chicken model, we expect to provide a platform to explore the role of lipids in the liver pathology linked with viral infections and contribute to the development of prophylactic interventions.

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Quantitative lipidomics reveals lipid perturbation in the liver of fatty liver hemorrhagic syndrome in laying hens

Cited by 11 publications

References 41 publications

Quantitative lipidomics reveals the changes of lipids and antioxidant capacity in egg yolk from laying hens with fatty liver hemorrhagic syndrome

Quantitative lipidomics reveals the changes of lipids and antioxidant capacity in egg yolk from laying hens with fatty liver hemorrhagic syndrome

Osteocalcin and Its Potential Functions for Preventing Fatty Liver Hemorrhagic Syndrome in Poultry

Development of fatty liver disease model using high cholesterol and low choline diet in white leghorn chickens

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