Comparative effects of different sclerosing agents used to treat rectal prolapse: An experimental study in rats

Ezer, Semire Serin; Kayaselçuk, Fazi̇let; Oğuzkurt, Pelin; Temız, Abdulkerım; İnce, Emine; Hiçsönmez, Akgün

doi:10.1016/j.jpedsurg.2012.11.048

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…A digital rectal examination was performed to rule out the presence of rectal polyps or other abnormalities. The sclerosing agent of choice was D50W, chosen for its safety and efficacious profile; D50W has been found to be an effective sclerosing agent, inducing increased fibroblast proliferation required for prevention of rectal prolapse (9). No other sclerosing agents were utilized.…”

Section: Methodsmentioning

confidence: 99%

Influence of Initial Treatment Strategy on Outcomes for Children With Rectal Prolapse

Rincon-Cruz,

Staffa,

Dickie

et al. 2023

Journal of Pediatric Gastroenterology &Amp; Nutrition

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Objective: Pediatric rectal prolapse is a common and often self-limited condition with multiple management options. Selecting the optimal approach requires personalization and remains a challenge for pediatricians and pediatric surgeons. Methods: A single-center retrospective review of 67 children with rectal prolapse undergoing surgical evaluation between 2010 and 2021. Patients with anorectal malformations, Hirschsprung disease, inflammatory bowel disease, and cystic fibrosis were excluded. We used multivariable logistic regression to compare medical management, sclerotherapy, and surgical correction (rectopexy or transanal resection) as initial treatment strategies, with a primary endpoint of prolapse resolution. Results: Younger patients (<5 years) were more likely to be initially treated with medical management alone (P < 0.001). Patients with a psychiatric diagnosis were more likely to be offered either sclerotherapy or surgery upfront (P = 0.009). The resolution rate with surgery as initial management was 79% (n = 11/14). The resolution rate with sclerotherapy as initial management was 54% (n = 13/24), with 33% (n = 8/24) resolving with sclerotherapy alone and 21% (n = 5/24) resolving after a subsequent surgical procedure (P = 0.011). Patients who underwent initial surgical management had an adjusted odds ratio of 8.0 (95% CI: 1.1–59.1; P = 0.042) for resolution of prolapse compared to patients who underwent sclerotherapy initially. Markers of severity (bleeding, need for manual reduction) were not associated with initial therapy offered (P = 0.064). Conclusions: Surgical intervention (sclerotherapy, rectopexy, transanal resection) resolved rectal prolapse in most children (63%). Surgery as an initial management approach had a significantly higher success rate than sclerotherapy, even after controlling for severity of disease, psychiatric diagnosis, need for manual reduction, and age.

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Section: Methodsmentioning

confidence: 99%

Influence of Initial Treatment Strategy on Outcomes for Children With Rectal Prolapse

Rincon-Cruz,

Staffa,

Dickie

et al. 2023

Journal of Pediatric Gastroenterology &Amp; Nutrition

View full text Add to dashboard Cite

show abstract

“…Injection sclerotherapy is a simple, cost-effective procedure with less complications. In fact, it is a day-care procedure [6,7]. Hypertonic saline has a low complication rate, is easy to inject, and is cost effective.…”

Section: Introductionmentioning

confidence: 99%