Comparative effects of avocado oil and losartan on blood pressure, renal vascular function, and mitochondrial oxidative stress in hypertensive rats

Márquez‐Ramírez, Cristian Adrián; Paz, José Lucio Hernández de la; Ortiz‐Avila, Omar; Raya-Farías, Andrés; González‐Hernández, Juan Carlos; Rodríguez-Orozco, Alain R.; Salgado‐Garciglia, Rafael; Saavedra‐Molina, Alfredo; Godínez-Hernández, Daniel; Cortés‐Rojo, Christian

doi:10.1016/j.nut.2018.02.024

Cited by 32 publications

(23 citation statements)

References 34 publications

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“…However, a large number of ROS may cause oxidative stress, loss of cell function, and tissue degeneration (Márquez-Ramírez et al, 2018). ROS could regulate vascular tension, and most studies have found that H 2 O 2 and ·O 2 cause vasoconstriction (Incalza et al, 2018).…”

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confidence: 99%

Antioxidant and antihypertensive effects of garlic protein and its hydrolysates and the related mechanism

Gao

Xue

et al. 2019

J Food Biochem

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Garlic protein (GP) was enzymatically hydrolyzed using pepsin and trypsin followed by the evaluation of antioxidant and angiotensin-converting enzyme (ACE) inhibitory activities of GP and its hydrolysates. The antihypertensive effects of GP and its hydrolysates were determined in vivo. The results showed that GP and its hydrolysates namely GPH-P (pepsin) and GPH-T (trypsin) possessed appreciable antioxidant and ACE inhibitory activities. The ACE inhibitory activity of GP, GPH-T, and GPH-P was in consistent with their antioxidant activities. GP and its hydrolysates offered significant protective effects against H 2 O 2 -induced oxidative damage (p < .05). In addition, the administration of GP, GPH-T, and GPH-P reduced the blood pressure in hypertensive rats. The mechanism might be to reduce blood pressure by inhibiting the activity of ACE, reducing the formation of ACEII, and protecting the activity of bradykinin. This study suggested that GP might be utilized as a promising functional food as antioxidant and antihypertensive agents. Practical applicationsGarlic (Allium sativum L.) is one of the oldest cultivated plants that belongs to the Liliaceae family and it has been used in cooking and medicinal applications. Large quantities of garlic residuals were produced with the development of the garlic essential oil industry. These residuals are highly rich in proteins and they can be used for the preparation of protein hydrolysates. Generally, hydrolysates are considered as a promising food supplement due to the enrichment of amino acids present in it.In this study, garlic proteins (GPs) and its hydrolysates retain effective antioxidant effects. They were found to reduce the blood pressure and prevent oxidative stress induced by H 2 O 2 . The information from this study could be used to develop a new nutritional supplement from GP and its hydrolysates to treat hypertension as well as prevent oxidative damage. K E Y W O R D SACE inhibitory activity, antioxidant, L02 cells, oxidative damage

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confidence: 99%

Antioxidant and antihypertensive effects of garlic protein and its hydrolysates and the related mechanism

Gao

Xue

et al. 2019

J Food Biochem

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“…Elevated cellular metabolism promotes metabolic accumulation and activates metaboreceptors. Therefore, the stimulation of non-myelinated afferent fibers elevates sympathetic activity, triggering increased HR, cardiac output, blood pressure and vasoconstriction in non-active muscles 45 . After exercise, progressive removal of metabolites during recovery from exercise decreases metaboreflex activation, restoring baroreflex activity 3 .…”

Section: Discussionmentioning

confidence: 99%

Avocado (Persea americana) pulp improves cardiovascular and autonomic recovery following submaximal running: a crossover, randomized, double-blind and placebo-controlled trial

Sousa

Valenti

Pereira

et al. 2020

Sci Rep

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previous studies have demonstrated that regular avocado consumption presents advantageous effects on cardiovascular system. However, little attention has been paid to the use of avocado as a dietary supplement, in particular, for individuals involved in physical exercise training. therefore, this study aims to evaluate the effect of acute avocado pulp intake on cardiovascular and autonomic recovery subsequent to moderate exercise. Using a crossover, randomized, double-blind and placebocontrolled trial design, 16 healthy female adults underwent two protocols: Avocado pulp (600 mg in capsule) and placebo (600 mg starch in capsule). After the ingestion of Avocado pulp or placebo, the subjects were seated for 60 min at rest, followed by running on a treadmill at a submaximal level and then remained seated for 60 min during recovery from the exercise. Heart rate (HR), heart rate variability (HRV) [rMSSD, SD1, HF (ms 2)] and skin conductance were evaluated before and during exercise, as well as during recovery. HR, systolic blood pressure, HRV and skin conductance recovered faster when subjects were given avocado pulp prior to exercise. in conclusion, avocado pulp improved cardiovascular and autonomic recovery after exercise, suggesting a reduced risk of cardiovascular events after exertion. The current results support the beneficial effects of ingestion of avocado prior to submaximal treadmill running. The autonomic nervous system is controlled by central areas in the brain and brainstem 1,2. During exercise the autonomic nervous system is responsible for physiological changes required to meet the contending demands of skin blood flow (thermoregulation) and the functioning muscles (metabolic loads), to maintain blood pressure and optimal organ perfusion 1. This is key to keeping the body healthy under stressful conditions 1,2. In the first few seconds of exercise, reduction of parasympathetic activity increases heart rate (HR), followed by an elevation

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“…In contrast, the results observed in the oil groups showed that consumption of the avocado oil-based diet has a protective effect on the kidney, even for the groups that received testosterone. It has been shown that beta-sitosterol isolated from plants, including avocado, is beneficial for kidney function, improves blood pressure (33), and may reverse the damage caused by diseases such as diabetes (34), renal dysfunction, or nephrotoxicity (16,35).…”

Section: Discussionmentioning

confidence: 99%

Consumption of avocado oil (Persea americana) improves the biochemical profile of rats submitted to long-term androgenic stimulation

Silva¹,

Boaventura²,

Abboud³

et al. 2020

Nutr Hosp

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Comparative effects of avocado oil and losartan on blood pressure, renal vascular function, and mitochondrial oxidative stress in hypertensive rats

Cited by 32 publications

References 34 publications

Antioxidant and antihypertensive effects of garlic protein and its hydrolysates and the related mechanism

Antioxidant and antihypertensive effects of garlic protein and its hydrolysates and the related mechanism

Avocado (Persea americana) pulp improves cardiovascular and autonomic recovery following submaximal running: a crossover, randomized, double-blind and placebo-controlled trial

Consumption of avocado oil (Persea americana) improves the biochemical profile of rats submitted to long-term androgenic stimulation

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