Comparative Effects of Aqueous and Ethanolic Leaf Extracts of Gongronema latifolium on Serum Kidney and Liver Biomarkers of Normal Male Rats

Acute and Sub-Acute Toxicity of Aqueous Extract of <i>Nauclea Latifolia</i> in Swiss Mice and in OFA Rats

“…AST and ALT levels in the groups which received high doses of the plant extract (18 and 180 mg/kg) for 28 days may be suggestive of an alteration in the secretory and excretory functions of the kidney [24,25] caused by the extract of N. latifolia stem. Our findings are partially supported by a previous report [16] which found a decrease in serum creatinine and urea but increase in serum AST and ALT in rats treated with the aqueous extract of N. latifolia.…”

“…The kidney plays a very important role in the removal of metabolic wastes from the blood stream. Its functionality, therefore, can be assessed among many others by determining the serum concentration of excretory constituents [24]. The significant decrease in serum creatinine, sodium ion and potassium ion was probably linked to metabolic alkalosis as revealed by the values of urine pH of 8 -9 for the 4 weeks of study.…”

Moringa oleifera Impairs the Morphology and Functions of the Kidney in Adult Wistar Rats

“…Alanine and Aspartate Transaminases are primary enzymes of the liver but are also present in the kidney (Nwangwu Spencer et al, 2011, Nwagwa, 2012. Elevated levels of Alanine and Aspartate Transaminases are, therefore, possible indicators of liver and kidney damage (Nwangwu Spencer et al; Nwagwa).…”