Acute and Sub-Acute Toxicity of Aqueous Extract of &lt;i&gt;Nauclea Latifolia&lt;/i&gt; in Swiss Mice and in OFA Rats

Kouadio, James H; Bleyere, Mathieu Nahounou; Koné, Mamadou Guy-Richard; Dano, Sébastien D.

doi:10.4314/tjpr.v13i1.16

Cited by 10 publications

(15 citation statements)

References 15 publications

(23 reference statements)

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“…Probably this might be due to high rate of recovery of blood cells from the effect of VPA. This do not corroborate the study of Kouadio et al [30] who reported elevation of platelets, erythrocytes and eosinophils reflecting potential benefits in blood coagulation, anemia and allergenic effect respectively. Valproic acid in previous studies has been shown to cause coagulopathy, platelet dysfunction and thrombocytopenia thought to be associated with possibly direct toxicity on bone marrow or VPA inclusion into platelet membrane due to similar fatty acid cell membranes [51].…”

Section: Discussioncontrasting

confidence: 99%

“…In the present study, there was steady weight gain (P < 0.001) during the treatment period. This indicates the absence of weight related adverse effect and possible improvement in nutritional status [30]. Previous study by Kouadio et al [30], also demonstrated significant weight gain in rats administered the aqueous stem -bark extract of Nauclea latifolia.…”

Section: Discussionmentioning

confidence: 74%

“…This indicates the absence of weight related adverse effect and possible improvement in nutritional status [30]. Previous study by Kouadio et al [30], also demonstrated significant weight gain in rats administered the aqueous stem -bark extract of Nauclea latifolia. Besides, no specific target organ toxicity was observed in rats intoxicated with VPA and those treated with NLS extract; but significant reduction in the liver weight of animals administered VPA 500 mg/kg and NLS extract 50 mg/kg body weight (P < 0.05) was noted.…”

Section: Discussionmentioning

confidence: 74%

“…The ethnomedicinal applications cover a large range of diseases, including painmanagement, diabetes, infections, and malaria [28,29]. Nauclea latifolia has been found to exert anti-hepatotoxic, hypoglycemic, anti-nociceptive, anti-inflammatory, anti-pyretic and other numerous activities in animal experimental models [30].…”

Section: Introductionmentioning

confidence: 99%

“…Though the NLS acute and subacute toxicity profile on hematological and biochemical profiles have been reported [30,32] but the effect of NLS on the histopathology of liver, kidney and the lungs and on multifocal toxicity -induced by VPA is yet to be reported. This study seek to update the existing gap and provide information of potential ameliorative effect of subacute administration of NLS extract on the multifocal toxicity induced by VPA in rats by evaluating the hematology, serum chemistry and reveal the histopathology of the liver, kidney and lungs.…”

Section: Introductionmentioning

confidence: 99%

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Nauclea latifolia (Rubiaceae) Stem-bark Hydromethanolic Extract Abrogates a Histone Deacetylase Inhibitor - Induced Multifocal Toxicity in Albino Rats

Nwidu

Oboma

2019

EJMP

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Objective: Nauclea latifolia (Rubiaceae) stem-bark enjoys wide patronage in ethnomedicine due to multiplicity of usage. Acute and subacute hematological and biochemical toxicity studies are available in literature but none underpins its ameliorative effect with a histone deacetylase inhibitor (HDAC), valproic acid (VPA) which mediates multifocal toxicity in different histological milieu. Methods: Subacute exposure of experimental albino rats with a high dose of valproic acid (500 mg/kg) was executed orally one hour before post-treatment with Nauclea latifolia stem-bark (NLS) extract in three doses (50, 100, 200 mg/kg) and with another group of rats with reference drug, vinpocetine, 25 mg/kg daily for 28 consecutive days after which hematological and biochemical analyses were executed. The liver, kidney and lungs were abstracted for histopathological evaluation. Results: The HDAC inhibitor, Valproic acids induced multifocal biochemical insults on liver function enzymes, lipid profiles, electrolytes and kidney function which were dose- dependently and significantly (P < 0.05 – 0.001) abrogated by the varying doses of administered NLS extract. On the histology the NLS extract effects corroborated the biochemical study in the liver and kidney. The NLS did not demonstrate significant toxicological impingement on the hematology and did not alter VPA-induced histomorphological injury in the lungs cytoarchitecture. The reference drug, vinpocetine was unresponsive to VPA-induced alteration in all the tissues investigated in the administered posology. Conclusion: The NLS extract was effective in abrogating toxicological insults in the liver and kidney but not in the lungs. Further studies are required to understand the mechanism of pharmacological effects of NLS extract and the differential in tissue response.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 74%