Comparative effectiveness of medicinal interventions for oral submucous fibrosis: A network meta-analysis

Rai, Arpita; Shrivastava, Priyanshu Kumar; Kumar, Ansul; Kumar, Amit; Prasad, Kameshwar; Shakeel, Saman; Haque, Zeya ul

doi:10.1016/j.jormas.2023.101423

Cited by 3 publications

(4 citation statements)

References 48 publications

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“…The use of antioxidants containing lycopene can counteract the detrimental impact of free radicals via physical and chemical means, thereby safeguarding cellular constituents against impairment caused by highly reactive oxygen species. However, the efficacy of lycopene as a standalone therapeutic agent has been found to be suboptimal compared with combination therapies in terms of enhancing mouth opening ( 11 ). Previous research has shown a significant improvement in mouth opening with mouth exercises, which was not observed in the present study ( 24 ).…”

Section: Discussionmentioning

confidence: 99%

“…The patients were also instructed to perform mouth opening exercises regularly with ice cream sticks five times a day, to perform massages with 0.1% triamcinolone oromucosal paste (Turbocort, Indoco Remedies Ltd.) twice daily and to rinse with benzydamine 0.15% mouthwash (B-mine Dupen Laboratories Pvt. Ltd.) for 1 year ( 11 ). All patients were followed-up at monthly visits, and repeated reminders were sent to their mobile phones to remind them to follow the prescription diligently and refrain from using areca nuts, tobacco products, alcohol, and hot and spicy foods.…”

Section: Methodsmentioning

confidence: 99%

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Comparative assessment of the efficacy of an intralesional injection of placentrex, hyaluronidase and dexamethasone in the management of oral submucous fibrosis: A randomized controlled trial

Goyal,

Iyer,

Palande

et al. 2024

Med Int

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The prevalent symptoms of oral submucous fibrosis (OSMF) are a burning sensation and trismus. The aim of the present study was to compare the efficacy of placentrex, hyaluronidase and dexamethasone, and their combination in the treatment of OSMF. For this purpose, 160 patients with OSMF were divided into four groups (each with 40 patients at a 1:1:1:1 allocation ratio). The patients in group 1 (control) received only oral supplements, along with regular mouth-opening exercises; patients in group 2 received an injection of placental extract; patients in group 3 were injected with hyaluronidase and dexamethasone; and patients in group 4 received a combination of injections from groups 2 and 3. The injections were administered once weekly for 12 weeks and patients were followed-up for 12 months. The data of the patients (mouth opening ability and a burning sensation) were analyzed using ANOVA and the Kruskal-Wallis test. The maximum increase in mouth opening (7.30±0.80 mm) was noted in group 4, and the lease increase was observed in the control group (0.37±0.16 mm), from baseline levels to the end of the 12th week. The maximum relapse in mouth opening of 1.62±0.45 mm was noted in group 2, and a minimum relapse of 0.20±0.08 mm was noted in group 4. On the whole, the present study demonstrates that the intralesional injection of a combination of the three drugs (placentrex, hyaluronidase and dexamethasone) in addition to the use of oral supplements and mouth opening exercises has a high level of efficacy in improving trismus and burning sensation in patients with OSMF.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Comparative assessment of the efficacy of an intralesional injection of placentrex, hyaluronidase and dexamethasone in the management of oral submucous fibrosis: A randomized controlled trial

Goyal,

Iyer,

Palande

et al. 2024

Med Int

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“…1,[4][5][6] The pathogenesis of OSF is multifactorial, with the betel nut component of areca nut, particularly the alkaloid arecoline, playing a significant role in collagen production and the development of oral submucosal fibrosis. 7 Genetic predisposition, immunological dysregulation, nutritional deficiencies, and autoimmune factors have also been implicated in OSF. 8,9 Recent investigations have further elucidated various aspects of OSF, including molecular changes associated with differential gene expression and epigenetic modifications, providing prospective biomarkers and therapeutic targets.…”

Section: Introductionmentioning

confidence: 99%

“…11 Management of OSF includes traditional therapies like steroids and antioxidants, as well as novel modalities such as pentoxifylline and collagenase, which have demonstrated efficacy in reducing fibrosis and improving symptoms. 7 Surgical techniques like tongue flaps and free tissue transfer have gained interest in the treatment of advanced OSF cases. 4,12 Rehabilitation programs involving speech therapy, physiotherapy, and psychosocial support are essential for enhancing the quality of life for OSF patients.…”

Section: Introductionmentioning

confidence: 99%

Nasolabial Flap in the Management of Oral Sub Mucous Fibrosis: A Series of Cases

Ullah¹,

Maqsood

Faheem

et al. 2023

Clin Med Insights Case Rep

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The objective of this study was to evaluate the outcomes of the nasolabial flap in the management of oral submucous fibrosis (OSMF). The descriptive case series included 75 patients diagnosed with OSMF who underwent surgical intervention under general anesthesia. Preoperative mouth opening measurements were compared with postoperative measurements taken after 2 months. Regarding mouth opening, out of the 75 patients, 4 (5.3%) had unsatisfactory results after treatment, while 22 (29.3%) experienced satisfactory outcomes. The majority of patients, 49 (65.3%), achieved normal mouth opening (more than 30 mm) following the Nasolabial flap procedure. This indicates that the Nasolabial flap yielded favorable results in terms of restoring normal mouth opening and benefiting the patients. Based on the findings of this study, the Nasolabial flap was determined to be a viable surgical option for managing oral submucous fibrosis due to its ease of operation, reliable flap vascularity, and low post-operative complication rate. The only drawback identified was the presence of a surgical scar, which can be addressed through secondary correction procedures.

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Stromal inflammation, fibrosis and cancer: An old intuition with promising potential

Oey¹,

Sunjaya²,

Khan³

et al. 2023

World J Clin Oncol

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It is now well established that the biology of cancer is influenced by not only malignant cells but also other components of the tumour microenvironment. Chronic inflammation and fibrosis have long been postulated to be involved in carcinogenesis. Chronic inflammation can promote tumorigenesis via growth factor/cytokine-mediated cellular proliferation, apoptotic resistance, immunosuppression; and free-radical-induced oxidative deoxyribonucleic acid damage. Fibrosis could cause a perturbation in the dynamics of the tumour microenvironment, potentially damaging the genome surveillance machinery of normal epithelial cells. In this review, we will provide an in-depth discussion of various diseases characterised by inflammation and fibrosis that have been associated with an increased risk of malignancy. In particular, we will present a comprehensive overview of the impact of alterations in stromal composition on tumorigenesis, induced as a consequence of inflammation and/or fibrosis. Strategies including the application of various therapeutic agents with stromal manipulation potential and targeted cancer screening for certain inflammatory diseases which can reduce the risk of cancer will also be discussed.

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Comparative effectiveness of medicinal interventions for oral submucous fibrosis: A network meta-analysis

Cited by 3 publications

References 48 publications

Comparative assessment of the efficacy of an intralesional injection of placentrex, hyaluronidase and dexamethasone in the management of oral submucous fibrosis: A randomized controlled trial

Comparative assessment of the efficacy of an intralesional injection of placentrex, hyaluronidase and dexamethasone in the management of oral submucous fibrosis: A randomized controlled trial

Nasolabial Flap in the Management of Oral Sub Mucous Fibrosis: A Series of Cases

Stromal inflammation, fibrosis and cancer: An old intuition with promising potential

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