Comparative, double-blind, controlled study of intra-articular hyaluronic acid (Hyalubrix®) injections versus local anesthetic in osteoarthritis of the hip

Migliore, Alberto; Massafra, Umberto; Bizzi, Emanuele; Vacca, Francesca; Martin-Martin, Severino; Granata, M.; Alimonti, Andrea; Tormenta, Sandro

doi:10.1186/ar2875

Cited by 75 publications

(66 citation statements)

References 28 publications

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“…An RCT by Migliore et al [45] compared HA with an intraarticular infiltration of a local anesthetic (mepivacaine). Both treatments showed a significant improvement in a visual analog score for pain (VAS pain) after 3 and 6 months compared with baseline (both p < 0.001), but when comparing the effect of HA with that of mepivacaine at 3 and 6 months, a more positive effect was reached in favor of HA (p < 0.05).…”

Section: Randomized Clinical Trialsmentioning

confidence: 99%

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Hyaluronic Acid for the Treatment of Osteoarthritis in all Joints Except the Knee

et al. 2012

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Our recommendation for future research is that one should focus on adequately powered randomized trials comparing HA treatment with other types of intra-articular or conservative treatment. We think it is useless to further perform and publish (large) non-comparative prospective studies about the use of HA in the treatment of problems caused by OA. It is well perceived that HA exerts positive effects in the treatment of OA, but up to now there is no (strong) evidence available that HA is superior to other treatments of OA such as corticosteroids, physiotherapy or other conservative measures.

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Section: Randomized Clinical Trialsmentioning

confidence: 99%

“…[22][23][24][25][26]28,30,36,[41][42][43][44][45]47] The baseline and the VAS pain at follow-up were pooled and compared. In some papers it was not clear if it was a report of a new series or a longer term follow up of a previously reported patient cohort; therefore these were included only once.…”

Section: Prospective Studiesmentioning

confidence: 99%

Hyaluronic Acid for the Treatment of Osteoarthritis in all Joints Except the Knee

et al. 2012

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“…Intra-articular injection of hyaluronic acid is still controversial in the management of hip osteoarthritis (OA), as its efficacy has not been clearly established. 3,[5][6][7][8][9] More recently, intra-articular injections of platelet-rich plasma (PRP) have been proposed but presently there is a paucity of data supporting its wide use in clinical practice.…”

Section: Intra-articular Aspirations and Injectionsmentioning

confidence: 99%

Interventional MSK procedures: the hip

Dodré¹,

Lefebvre²,

Cockenpot³

et al. 2016

BJR

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Percutaneous musculoskeletal procedures are widely accepted as low invasive, highly effective, efficient and safe methods in a vast amount of hip pathologies either in diagnostic or in therapeutic management. Hip intra-articular injections are used for the symptomatic treatment of osteoarthritis. Peritendinous or intrabursal corticosteroid injections can be used for the symptomatic treatment of greater trochanteric pain syndrome and anterior iliopsoas impingement. In past decades, the role of interventional radiology has rapidly increased in metastatic disease, thanks to the development of many ablative techniques. Image-guided percutaneous ablation of skeletal metastases provides a minimally invasive treatment option that appears to be a safe and effective palliative treatment for localized painful lytic lesion. Methods of tumour destruction based on temperature, such as radiofrequency ablation (RFA) and cryotherapy, are performed for the management of musculoskeletal metastases. MR-guided focused ultrasound surgery provides a non-invasive alternative to these ablative methods. Cementoplasty is now widely used for pain management and consolidation of acetabular metastases and can be combined with RFA. RFA is also used to treat benign tumours, namely osteoid osteomas. New interventional procedures such as percutaneous screw fixation are also proposed to treat non-displaced or minimally displaced acetabular roof fractures. INTRODUCTIONHip intra-articular injections have been used for many years as a diagnostic and/or therapeutic tool and even today remain an effective treatment for osteoarthritis providing pain relief. Ultrasound guidance can be used for injections in patients with greater trochanteric pain syndrome and CT scan guidance for corticosteroid injection in the management of anterior iliopsoas impingement after total hip arthroplasty. Interventional radiology plays a major role in the management of bone tumours. Several image-guided percutaneous ablation methods have proved effective for palliation of metastases involving bone and for the treatment of benign bone tumours, namely osteoid osteoma. To treat pain and consolidate the bone, cementoplasty could be required. In the therapeutic management of acetabular fractures, the combination of CT and fluoroscopy guidance could have a place in treating non-displaced or minimally displaced acetabular roof fractures.

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“…Other factors that have been reported to predict better response to treatment were age greater than 60 years and lower baseline functional capacity [71]. HA use for joints such as shoulder [72], hip [73] and first carpometacarpal joint [74] have been reported recently. The most common AE is a transient injection site reaction with mild redness, warmth and swelling in 20-30%.…”

Section: Hyaluronic Acid (Ha)mentioning

confidence: 99%

Non-surgical treatment of osteoarthritis-related pain in the elderly

Mushtaq

Choudhary

Scanzello

2011

Curr Rev Musculoskelet Med

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Osteoarthritis (OA), the third most common diagnosis in the elderly [1], causes significant pain leading to disability and decreased quality of life in subjects 65 years and older [2]. Traditionally, clinicians have relied heavily on the use of non-steroidal anti-inflammatory drugs (NSAIDs) to treat the pain of OA, as numerous studies have proven these agents to be effective. The cardiovascular, gastrointestinal, renal and hepatic toxicities of NSAIDs have limited their use, particularly in the elderly. Acetaminophen has been recommended as initial therapy due to relative safety. Several other topical, oral and intra-articular agents are available today, with use limited by efficacy and side effect profiles. Many non-pharmacologic approaches are available but underused, and may be attractive choices to avoid poly-pharmacy in older patients. We will attempt to highlight the evidence behind available non-surgical therapies for OA while paying specific attention to issues in geriatric patients.

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Comparative, double-blind, controlled study of intra-articular hyaluronic acid (Hyalubrix®) injections versus local anesthetic in osteoarthritis of the hip

Cited by 75 publications

References 28 publications

Hyaluronic Acid for the Treatment of Osteoarthritis in all Joints Except the Knee

Hyaluronic Acid for the Treatment of Osteoarthritis in all Joints Except the Knee

Interventional MSK procedures: the hip

Non-surgical treatment of osteoarthritis-related pain in the elderly

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