Comparative Cytogenetic Analysis of Sex Chromosomes in Several <i>Canidae</i> Species Using Zoo-FISH

Bugno‐Poniewierska, Monika; Sojecka, Agnieszka; Pawlina, Klaudia; Jakubczak, Andrzej; Jeżewska-Witkowska, Grażyna

doi:10.3409/fb60_1-2.11-16

Cited by 8 publications

(4 citation statements)

References 30 publications

(38 reference statements)

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“…Only the males amplified confirming the Y‐chromosome positioning of these markers in red foxes, as was expected given high homology among sex chromosomes of red foxes and dogs (Bugno‐Poniewierska et al . ).…”

Section: Methodsmentioning

confidence: 97%

Range‐wide multilocus phylogeography of the red fox reveals ancient continental divergence, minimal genomic exchange and distinct demographic histories

et al. 2014

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Widely distributed taxa provide an opportunity to compare biogeographic responses to climatic fluctuations on multiple continents and to investigate speciation. We conducted the most geographically and genomically comprehensive study to date of the red fox (Vulpes vulpes), the world's most widely distributed wild terrestrial carnivore. Analyses of 697 bp of mitochondrial sequence in ~1000 individuals suggested an ancient Middle Eastern origin for all extant red foxes and a 400 kya (SD = 139 kya) origin of the primary North American (Nearctic) clade. Demographic analyses indicated a major expansion in Eurasia during the last glaciation (~50 kya), coinciding with a previously described secondary transfer of a single matriline (Holarctic) to North America. In contrast, North American matrilines (including the transferred portion of Holarctic clade) exhibited no signatures of expansion until the end of the Pleistocene (~12 kya). Analyses of 11 autosomal loci from a subset of foxes supported the colonization time frame suggested by mtDNA (and the fossil record) but, in contrast, reflected no detectable secondary transfer, resulting in the most fundamental genomic division of red foxes at the Bering Strait. Endemic continental Y-chromosome clades further supported this pattern. Thus, intercontinental genomic exchange was overall very limited, consistent with long-term reproductive isolation since the initial colonization of North America. Based on continental divergence times in other carnivoran species pairs, our findings support a model of peripatric speciation and are consistent with the previous classification of the North American red fox as a distinct species, V. fulva.

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Section: Methodsmentioning

confidence: 97%

Range‐wide multilocus phylogeography of the red fox reveals ancient continental divergence, minimal genomic exchange and distinct demographic histories

et al. 2014

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“…Genetic variations in free-living and farm foxes have been studied by many authors (Jakubczak et al 2009(Jakubczak et al , 2011(Jakubczak et al , 2014a(Jakubczak et al , 2014bBugno-Poniewierska et al 2012;Jezewska-Witkowska et al 2012). In this study, SNPs of genes taking part in melanogenesis in natural and farm populations were compared for the first time.…”

Section: Discussionmentioning

confidence: 96%

Single-nucleotide polymorphism of MC1R, ASIP, and TYRP2 genes in wild and farmed foxes (Vulpes vulpes)

et al. 2016

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DNA mutations within genes associated with melanogenesis can affect melanin production, leading to dyschromias. Genes that are involved in synthesis of melatonin and may affect the color of skin are melanocortin 1 receptor (MC1R), agouti locus (ASIP), and tyrosinase-related protein-2 (TYRP2). In this study, SNP identification within ASIP, MC1R, and TYRP2 gene fragments in wild and farmed foxes (Vulpes vulpes) was performed. Nine mutations in the ASIP gene which allowed us to distinguish seven SNP profiles, fourteen mutations and five SNP profiles in the MC1R gene, and seven SNP profiles based on four polymorphic nucleotides in the TYRP2 gene were detected. Analyses of obtained profiles indicate that ASIP did not undergo mutations in the wild, and significant variability of SNP profiles was found for TYRP2, with specific haplotypes noted for farm foxes and American and European wild foxes.Key words: ASIP, MC1R, TYRP2, SNP, melanogenesis, Vulpes vulpes.Résumé : Les mutations d'ADN dans les gènes associés à la mélanogénèse peuvent avoir un effet sur la production de mélanine, ce qui peut se solder par des dyschromies. Les gènes qui sont associés à la synthèse de mélatonine et peut avoir un effet sur la couleur de peau sont le récepteur de la mélanocortine 1 (MC1R -« melanocortin 1 receptor »), le locus agouti (ASIP), et la protéine 2 associée à la tyrosinase (TYRP2 -« tyrosine-related protein-2 »). Dans cette étude, l'identification par SNP dans les fragments de gènes ASIP, MC1R et TYRP2 a été effectuée chez les renards (Vulpes vulpes) sauvages et d'élevage. Neuf mutations dans le gène ASIP qui ont permis de distinguer sept profils SNP, quatorze mutations et cinq profils SNP dans le gène MC1R, et sept profils SNP basés sur quatre nucléotides polymorphiques dans le gène TYRP2 ont été décelées. L'analyse des profils obtenus indique qu'ASIP ne subit pas de mutations dans la nature, qu'il y a une variabilité significative des profils SNP trouvés pour TYRP2, avec des haplotypes spécifiques notés pour les renards d'élevage et les renards sauvages de l'Amérique et de l'Europe. [Traduit par la Rédaction]

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“…Genetic differentiation between wild and farmed animals of the Canidae family is confi rmed by research by Bugno-Poniewierska et al using the FISH technique [26,27]. Studies on variation in wild and farmed individuals of different Canidae species have been and continue to be carried out at many levels, including diversity of morphological and physiological parameters and of phenotypic characteristics, as well as at the molecular and cytogenic level [28,29].…”

Section: Discussionmentioning

confidence: 99%

SNP Genetic Diversity Within a Fragment of the Gene Myo15a Responsible for the Hearing Process in a Population of Farmed and Free-Living Animals of the Canidae Family/SNP Genetski Deverzitet U Okviru Fragmenta Gena Myo15a, Odgovornog Za Sluh U Populaciji Životinja Familije Canidae U Uslovima Farmskog I Slobodnog Uzgoja

et al. 2014

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The gene MYO15A is involved in the production of a protein included in the group of motor proteins known as myosins. Myosin XVA is located in the inner ear, the pituitary gland and other tissues, and has a substantial infl uence on the hearing process. Mutations in this gene cause amino acid substitutions in the conserved motor domain of the myosin chain, leading to shortening of the stereocilia in the hair cells, so that the function of myosin XVA is impaired. A research hypothesis was put forth that mutations in the gene responsible for the hearing process in animals of the Canidae family can cause hypoacusis, as well as substantial behavioural changes in dogs (ranging from timidity to aggressive behaviour). The study determined SNP polymorphism in a fragment of the gene MYO15A, which can cause hearing disorders or hypoacusis, in wild and farmed individuals of the Canidae family.

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Comparative Cytogenetic Analysis of Sex Chromosomes in Several Canidae Species Using Zoo-FISH

Cited by 8 publications

References 30 publications

Range‐wide multilocus phylogeography of the red fox reveals ancient continental divergence, minimal genomic exchange and distinct demographic histories

Range‐wide multilocus phylogeography of the red fox reveals ancient continental divergence, minimal genomic exchange and distinct demographic histories

Single-nucleotide polymorphism of MC1R, ASIP, and TYRP2 genes in wild and farmed foxes (Vulpes vulpes)

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