Comparative conditioned passive avoidance test study of the effect of amiridine on learning and memory in old rats

Effect of amiridine and tacrine on the functional degeneration of the isolated neuron

“…The same concentration of tacrine, a drug structurally similar to amiridine, inhibited spontaneous impulse activity, whereas lower concentrations were inactive and higher doses decreased LT. These findings are in conformity with previous data on the antiamnestic effect of low doses of amiridine [4,6,9] and the suppression of the conditioned response in intact rats caused by high doses of the preparation [5]. Moreover, this experiment corroborates the importance of our previous observation that low concentrations of amiridine and tacrine (<1 pM) shift the region of activation of calcium currents in electroexcitable membranes toward hyperpolarization of the membrane potential, and ultimately to a more reliable generation of the nervous impulse [3].…”

“…Anthracycline antibiotics are widely used in the chemotherapy of malignant neoplasms [3,4]. However, their strong toxic effect on healthy organs and tissues with a high proliferative activity calls for scrupulous experimental studies of these preparations [6].…”

“…Tacrine, an agent structurally similar to amiridine, is used in the West for the treatment of ASD [11]o Experiments with various models of memory disorders have demonstrated that both amiridine and tacrine possess pronounced antiamnestic activity [4,6,9]. Amiridine weakens behavioral signs of Parkinson's disease in monkeys induced by neurotoxin MPTP (1-methyl-4-phenyl-l,2,3,6-tetrahydropyridine) [2].…”

The effect of a new 9-aminoacridine derivative on working and long-term memory in rats

“…Scopolamine (1 mg/kg) was injected 15 min prior to the session starting from the 5th session. The doses were determined on the basis of our previous studies [3]. To evaluate the effects of the drugs the following indices were used: the number of repeated entries into the reinforced arms ( working memory errors); the number of 3 consecutive entries into the reinforced arms ( long-term memory) [5].…”

Comparative study of the effect of amiridine on biological membranes

“…The drug has proved to be highly effective in the treatment of dementias of different genesis, including Alzheimer's senile dementia [8]. Previous studies using molecular probes and gas-liquid and thin-layer chromatography demonstrated that in some models of memory disorders the antiamnestic activity of amiridine was paralleled by its normalizing effect on the microviscosity of synaptosomal Iipids [2,3,9]. Single or repeated injections of the drug to intact rats did not cause changes in microviscosity [3].…”