The effect of nitroxyalkyl derivatives of fullerenylproline methyl ester on the enzymatic activity of Ca 2+ -ATPase of sarcoplasmic reticulum (SR) has been studied. It is shown that hybrid derivatives of C 60 fullerene are capable of inhibiting the activity of Ca 2+ -ATPase of SR. The mononitrate inhibits the hydrolytic activity of the enzyme with K i = 1.92´10 -6 M; active Ca 2+ transport, with K i = 3.79´10 -6 M. The dinitrate inhibits ATP hydrolysis with K i = 2.38´10 -8 M; Ca 2+ transport, with K i = 3.08´10 -8 M. Fullerenylproline methyl ester does not affect the enzymatic activity of Ca 2+ -ATPase. Based on these data it is possible to predict the possible fields of application for hybrid fullerene derivatives as potential drugs.
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