The results of the analysis of the current state of creating a technical means of mass immunoprophylaxis for dangerous infectious diseases are presented, including the technical level and trends in the development of developments on this problem in the Russian Federation and abroad. It was noted that in emergency situations of a biological nature, a vaccination campaign should be carried out in a short time with maximum personnel vaccination coverage, which is a massive undertaking. These requirements can be only be met with the use of mass vaccination in the form of needle-free, inhalation (aerosol) and oral vaccine administration methods. The wide use of these methods is constrained by a meager range of domestic oral vaccines, as well as the lack of technical means of mass immunization (aerosol generators, needleless injectors). This article shows that the needleless injector NI-30 (Russia) is the most appropriate for mass vaccination, in terms of technical level and operational characteristics. However, it cannot be recognized as fully meeting modern requirements due to a number of negative aspects, such as the rather large overall injector dimensions creating a large amount of obsolete structural materials. Thus, it is necessary to take into account the features of the available methods of vaccine administration when assessing the prospects for mass immunization, and it is necessary to substantiate the tactical and technical requirements for new generation samples in order to develop the technical means of mass immunization. Therefore, the development and introduction into practice of high-performance methods of mass immunization and the technical means for their implementation continues to be an urgent task.