Comparative Chondroprotective Effects of Intra-Articular Hyaluronic Acid and Triamcinolone in Murine Model of Osteoarthritis

Ishaq, Noaman; Gul, Shahzad; Gul, Mahwish; Ata, Nausheen; Batool, Saba; Mehdi, Quratulain

doi:10.55519/jamc-01-9566

Cited by 4 publications

(3 citation statements)

References 23 publications

(24 reference statements)

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“…The physically induced model produces KOA by causing instability during surgery, such as ACLT and meniscectomy. 47 , 48 Chemically induced KOA is caused by injecting chemical drugs, such as MIA, papain, and collagenase, to alter homeostasis and destroy joint structure. 49 , 50 , 51 In addition to the aforementioned methods, there are many other methods to induce the KOA model, such as freezing and fat induction.…”

Section: Methods Of Establishing Koa Animal Modelsmentioning

confidence: 99%

“…The secondary models can be caused by physical or chemical pathogenic factors to induce certain damage to animal tissues, organs, or the whole body, and some symptoms similar to those of human diseases. The physically induced model produces KOA by causing instability during surgery, such as ACLT and meniscectomy 47,48 . Chemically induced KOA is caused by injecting chemical drugs, such as MIA, papain, and collagenase, to alter homeostasis and destroy joint structure 49–51 .…”

Section: Methods Of Establishing Koa Animal Modelsmentioning

confidence: 99%

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Knee osteoarthritis: A review of animal models and intervention of traditional Chinese medicine

Song,

Liu,

Chen

et al. 2024

Anim Models and Exp Med

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BackgroundKnee osteoarthritis (KOA) characterized by degeneration of knee cartilage and subsequent bone hyperplasia is a prevalent joint condition primarily affecting aging adults. The pathophysiology of KOA remains poorly understood, as it involves complex mechanisms that result in the same outcome. Consequently, researchers are interested in studying KOA and require appropriate animal models for basic research. Chinese herbal compounds, which consist of multiple herbs with diverse pharmacological properties, possess characteristics such as multicomponent, multipathway, and multitarget effects. The potential benefits in the treatment of KOA continue to attract attention.PurposeThis study aims to provide a comprehensive overview of the advantages, limitations, and specific considerations in selecting different species and methods for KOA animal models. This will help researchers make informed decisions when choosing an animal model.MethodsOnline academic databases (e.g., PubMed, Google Scholar, Web of Science, and CNKI) were searched using the search terms “knee osteoarthritis,” “animal models,” “traditional Chinese medicine,” and their combinations, primarily including KOA studies published from 2010 to 2023.ResultsBased on literature retrieval, this review provides a comprehensive overview of the methods of establishing KOA animal models; introduces the current status of advantages and disadvantages of various animal models, including mice, rats, rabbits, dogs, and sheep/goats; and presents the current status of methods used to establish KOA animal models.ConclusionThis study provides a review of the animal models used in recent KOA research, discusses the common modeling methods, and emphasizes the role of traditional Chinese medicine compounds in the treatment of KOA.

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Section: Methods Of Establishing Koa Animal Modelsmentioning

confidence: 99%

Section: Methods Of Establishing Koa Animal Modelsmentioning

confidence: 99%

Knee osteoarthritis: A review of animal models and intervention of traditional Chinese medicine

Song,

Liu,

Chen

et al. 2024

Anim Models and Exp Med

View full text Add to dashboard Cite

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“…Therefore, both intestinal defense function and immune regulation function are reduced. A large number of bacteria and their metabolites enter the body through the intestinal mucosal barrier, causing or aggravating the occurrence of UC (Randlane et al, 2017;Ishaq et al, 2017). In recent years, along with the further study of the protective effect of the intestinal barrier, more and more attention has been paid to the intestinal mucosal barrier against the diseases caused by the invasion of foreign pathogens.…”

mentioning

confidence: 99%

Seroprevalence of Brucella abortus in Yak, Zo and Cows in Gilgit and Nagar Districts of Gilgit-Baltistan, Pakistan

Abbas¹

2024

PJZ

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Corticosteroid injections for the treatment of osteoarthritis present a wide spectrum of effects ranging from detrimental to disease‐modifying: A systematic review of preclinical evidence by the ESSKA Orthobiologic Initiative

Bensa,

Salerno,

Boffa

et al. 2024

Knee surg. sports traumatol. arthrosc.

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PurposeAim of this systematic review of preclinical evidence was to determine the effects of intra‐articular corticosteroid (CS) injections in joints affected by osteoarthritis (OA).MethodsA systematic review was performed on animal studies evaluating intra‐articular CS injections for OA joints. The search was performed on PubMed, Cochrane, and Web of Science databases. A synthesis of the results was performed investigating CS effects by evaluating studies comparing CS with control groups. Morphological, histological, immunohistochemistry evaluations, clinical outcomes, biomarkers and imaging results were evaluated. The risk of bias was assessed according to the Systematic Review Centre for Laboratory Animal Experimentation's tool.ResultsThirty‐two articles analysing CS effects in OA animal models were included (1079 joints), 18 studies on small and 14 on large animals. CS injections showed overall positive effects in at least one of the outcomes in 68% of the studies, while 16% reported a deleterious effect. CS improved cartilage and synovial outcomes in 68% and 60% of the studies, but detrimental effects were documented in 11% and 20% of the studies, respectively. Clinical parameters evaluated in terms of pain, lameness or joint swelling improved in 63% of the studies but deteriorated in 13%. Evidence is limited on imaging and biomarkers results, as well as on the best CS type, dose, formulation and injection protocol. The risk of bias assessment revealed a 28% low and an 18% high risk of bias.ConclusionIntra‐articular CS injections induced a wide range of results on OA joints in experimental animal models, from disease‐modifying and positive effects on pain and joint function at short‐term evaluation to the lack of benefit or even negative effects. This underlines the need to identify more specific indications and treatment modalities to avoid possible detrimental effects while maximising the anti‐inflammatory properties and the benefits of intra‐articular CS in OA joints.Level of EvidenceLevel II.

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Comparative Chondroprotective Effects of Intra-Articular Hyaluronic Acid and Triamcinolone in Murine Model of Osteoarthritis

Cited by 4 publications

References 23 publications

Knee osteoarthritis: A review of animal models and intervention of traditional Chinese medicine

Knee osteoarthritis: A review of animal models and intervention of traditional Chinese medicine

Seroprevalence of Brucella abortus in Yak, Zo and Cows in Gilgit and Nagar Districts of Gilgit-Baltistan, Pakistan

Corticosteroid injections for the treatment of osteoarthritis present a wide spectrum of effects ranging from detrimental to disease‐modifying: A systematic review of preclinical evidence by the ESSKA Orthobiologic Initiative

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