Comparative Assessments, Meta-Analysis, and Recommended Guidelines for Reporting Studies on Histomorphometric Bone-Implant Contact in Humans

Sağırkaya, Elçin; Küçükekenci, Ahmet Serkan; Karasoy, Durdu; Akça, Kıvanç; Eckert, Steven E; Çehreli, Murat Cavit

doi:10.11607/jomi.3166

Cited by 22 publications

(11 citation statements)

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“…The available literature on bone-implant interface involves a wide range of studies with various methods and results; thus the impact of one surface over another can barely be compared [41]. Arguably, the most insidious source of confounding is the method of bone to implant contact assessment.…”

Section: Discussionmentioning

confidence: 99%

Effect of Zirconia Dental Implant Surfaces on Bone Integration: A Systematic Review and Meta-Analysis

Hafezeqoran

Koodaryan

2017

BioMed Research International

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Background. The information available about osseointegration and the bone to implant interaction of zirconia implants with various surface modifications is still far from sufficient. Objective. The purpose of this systematic review and meta-analysis was to evaluate and compare zirconia dental implants with different surface topographies, with a focus on bone to implant contact and removal torque. Methods. The systematic review of the extracted publications was performed to compare the bone to implant contact (BIC) with removal torque (RT) values of titanium dental implants and machined and surfaced modified zirconia implants. Results. A total of fifteen articles on BIC and RT values were included in the quantitative analysis. No significant difference in the BIC values was observed between titanium and machined zirconia implants (p = 0.373; 95% CI: −0.166 to 0.443). However, a significantly better BIC values were observed for acid etched zirconia implants compared with those of titanium implants (p = 0.032; 95% CI: 0.068 to 1.461). Unmodified zirconia implants showed favorable BIC values compared to modified-surface zirconia implants (p = 0.021; 95% CI: −0.973 to −0.080). Conclusion. Acid etched zirconia implants may serve as a possible substitute for successful osseointegration.

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Section: Discussionmentioning

confidence: 99%

Effect of Zirconia Dental Implant Surfaces on Bone Integration: A Systematic Review and Meta-Analysis

Hafezeqoran

Koodaryan

2017

BioMed Research International

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“…Unfortunately, only a few studies in the present literature have dealt with histologic/histomorphometric evaluation of human-retrieved implants [ 23 , 25 – 29 ]; this is because of ethical issues related to implant retrieval from human subjects [ 23 ]. For this reason, little is known about the effects of different implant designs and surfaces on the early bone healing around dental implants [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, few studies to date have compared the influence of the macro- and micro/nanostructure of different implant systems on bone healing in humans [ 23 , 25 – 29 ]: this is because it is difficult to perform comparative histologic and histomorphometric studies in humans, for ethical reasons.…”

Section: Introductionmentioning

confidence: 99%

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Early Bone Formation around Immediately Loaded Transitional Implants Inserted in the Human Posterior Maxilla: The Effects of Fixture Design and Surface

Mangano

Shibli

Pires

et al. 2017

BioMed Research International

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Aim. To evaluate the effects of fixture design and surface on the early bone formation around immediately loaded implants inserted in the human posterior maxilla. Materials and Methods. Ten totally edentulous subjects received two transitional implants: one tapered implant with knife-edge threads/nanostructured calcium-incorporated surface (test: Anyridge®, Megagen, Gyeongbuk, South Korea) and one cylindrical implant with self-tapping threads/sandblasted surface (control: EZPlus®, Megagen). The implants were placed according to a split-mouth design and immediately loaded to support an interim complete denture; after 8 weeks, they were removed for histologic/histomorphometric analysis. The bone-to-implant contact (BIC%) and the bone density (BD%) were calculated. The Wilcoxon test was used to evaluate the differences. Results. With test implants, a mean BIC% and BD% of 35.9 (±9.1) and 31.8 (±7.5) were found. With control implants, a mean BIC% and BD% of 29.9 (±7.6) and 32.5 (±3.9) were found. The mean BIC% was higher with test implants, but this difference was not significant (p = 0.16). Similar BD% were found in the two groups (p = 0.9). Conclusions. In the posterior maxilla, under immediate loading conditions, implants with a knife-edge thread design/nanostructured calcium-incorporated surface seem to increase the peri-implant endosseous healing properties, when compared to implants with self-tapping thread design/sandblasted surface.

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“…Morphogenesis of osseointegration and assessment of the degree of bone-to-implant contact is usually performed by means of histological evaluation [12], while the underlying molecular processes may be more precisely evaluated at genetic level [13,14]. Data from gene expression analyses of fracture healing provide the basis for understanding these processes [15].…”

Section: Introductionmentioning

confidence: 99%

Genomic analyses of early peri-implant bone healing in humans: a systematic review

Shanbhag

Shanbhag²,

Stavropoulos

2015

Int J Implant Dent

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ObjectiveThe objective of the study was to systematically review the literature for studies reporting gene expression analyses (GEA) of the biological processes involved in early human peri-implant bone healing.MethodsElectronic databases (MEDLINE, EMBASE) were searched in duplicate. Controlled and uncontrolled studies reporting GEA of human peri-implant tissues - including ≥5 patients and ≥2 time points - during the first 4 weeks of healing were eligible for inclusion. Methodological quality and risk of bias were also assessed.ResultsFour exploratory studies were included in reporting GEA of either tissues attached to SLA or SLActive implants after 4 to 14 days or cells attached to TiOBlast or Osseospeed implants after 3 to 7 days. A total of 111 implants from 43 patients were analyzed using validated array methods; however, considerable heterogeneity and risk of bias were detected. A consistent overall pattern of gene expression was observed; genes representing an immuno-inflammatory response were overexpressed at days 3 to 4, followed by genes representing osteogenic processes at day 7. Genes representing bone remodeling, angiogenesis, and neurogenesis were expressed concomitantly with osteogenesis. Several regulators of these processes, such as cytokines, growth factors, transcription factors, and signaling pathways, were identified. Implant surface properties seemed to influence the healing processes at various stages via differential gene expression.ConclusionLimited evidence from gene expression studies in humans indicates that osteogenic processes commence within the first post-operative week and they appear influenced at various stages by implant surface properties.

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Comparative Assessments, Meta-Analysis, and Recommended Guidelines for Reporting Studies on Histomorphometric Bone-Implant Contact in Humans

Cited by 22 publications

References 0 publications

Effect of Zirconia Dental Implant Surfaces on Bone Integration: A Systematic Review and Meta-Analysis

Effect of Zirconia Dental Implant Surfaces on Bone Integration: A Systematic Review and Meta-Analysis

Early Bone Formation around Immediately Loaded Transitional Implants Inserted in the Human Posterior Maxilla: The Effects of Fixture Design and Surface

Genomic analyses of early peri-implant bone healing in humans: a systematic review

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