Comparative assessment of the biological activity of the green synthesized silver nanoparticles and aqueous leaf extract of Perilla frutescens (L.)

Abstract

Green synthesized nanoparticles (GSNPs) display fascinating properties compared to physical and chemical synthesized ones. GSNPs are currently used in numerous applications such as food packaging, surface coating agents, environmental remediation, antimicrobial, and medicine. In the present study, the aqueous leaf extract of Perilla frutescens L. having suitable capping, reducing, and stabilizing compounds was used for green synthesis of silver nanoparticles (Pf-AgNPs). The bioreductant capacity of aqueous leaf extract of P. frutescens for Pf-AgNPs was determined by different confirmatory techniques including UV–Visible spectroscopy, XRD, FESEM, EDX, zeta potential, DLS, SERS, and FTIR analysis. The results exhibited that Pf-AgNPs had optimal size (< 61 nm), shape (spherical), and stability (− 18.1 mV). The antioxidant activity of Pf-AgNPs with both DPPH and FRAP assays was significantly higher compared to P. frutescens extract. Furthermore, Pf-AgNPs had high antimicrobial activity against Escherichia coli and Staphylococcus aureus (MIC = 0.78 mg/mL), and Candida albicans (MIC = 8 mg/mL) while the plant extract showed low antimicrobial activity against both bacterial strains and the fungus tested. Pf-AgNPs and P. frutescens extract also exhibited moderate toxicity on MCF-7 cancer cells with IC50 values of 346.2 and 467.4 µg/mL, respectively. The results provide insights into using the biosynthesized Pf-AgNPs as an eco-friendly material for a wide range of biomedical applications.

Novel carbon nanoparticles (CNPs) fromCatharanthus roseuspetals for metal ion sensing and root growth modulation

“…Plant sources have been utilized as capping and reducing agents in the preparation of NPs with metals as doping agents. Silver nanoparticles (AgNPs) from the leaf extracts of P. frutescens (Tavan et al, 2023), flower extracts of Catharanthus roseus (Kandiah & Chandrasekaran, 2021), and gold nanoparticles (AuNPs) from the leaf extract of Ceiba pentandra (Aji et al, 2022), and many more have been prepared. Whereas crude extracts from various plant products have been used to prepare NPs without any doping agents, such as from cabbage juice (Alam et al, 2015), orange juice (Sahu et al, 2012), lemon juice (Ding et al, 2017), peel of Trapa bispinosa (Mewada et al, 2013), etc.…”

Bacteria-mediated green synthesis of silver nanoparticles and their antifungal potentials against Aspergillus flavus

“…Among inorganic antimicrobial agents, silver has been used most extensively since ancient times to combat infections [ 14 ]. Compared to other microorganisms, fungi have the ability to produce a large amount of metabolites, which makes them more suitable for the production of nanoparticles [ 4 , 15 ]. It is well known that many microbes, both unicellular and multicellular, produce inorganic materials, intracellular or extracellular [ 2 ].…”