Comparative assessment of the acute toxicity, haematological and genotoxic effects of ten commonly used pesticides on the African Catfish, Clarias gariepinus Burchell 1822

Amaeze, Nnamdi Henry; Komolafe, Benjamin; Salako, Abdulbashir Femi; Akagha, Kingsley Kelechi; Briggs, Tam-Miete D.; Olatinwo, Opeyemi Olayode; Femi, Micheal Abiodun

doi:10.1016/j.heliyon.2020.e04768

Cited by 35 publications

(20 citation statements)

References 45 publications

(49 reference statements)

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“…Various types of toxicities arisen from the pollutants including heavy metals [ 6 , 7 ], microplastics [ 8 , 9 ], pesticides [ 10 , 11 ] etc. have made the aquatic faunal communities one of the most unvoiced victims.…”

Section: Introductionmentioning

confidence: 99%

Assessment of heavy metals in farmed shrimp, Penaeus monodon sampled from Khulna, Bangladesh: An inimical to food safety aspects

Biswas¹,

Soma²,

Rohani

et al. 2021

Heliyon

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The analytical experiment was executed to present detailed reports on the concentration of heavy metals (nickel, iron, zinc, manganese, chromium, lead, and cadmium) in farmed shrimp, Penaeus monodon and its concomitant human health risks upon consumption. A total of 147 farms from six sub-districts of Khulna were selected for sample collection and concentration of heavy metals were determined by Atomic Absorption Spectrometry (AAS) method, following electro-thermal heater digestion. Ni and Cr were found considerably below the detectable limit (BDL) in four sub-districts, while Cr found in shrimps from Rupsa and Paikgacha were far higher than the maximum recommended limit defined by FAO and WHO. The average concentrations of Fe and Mn in all sub-districts crossed the recommendations, whereas average concentrations of Zn, Ni, Cd, and Pb were within the recommendations. Regardless of sampling site, target hazard quotients (THQ) of more than 1 contributed by Fe confirmed higher level of hazard index (HI), indicating potential human health risk. Fortunately, no heavy metal or their additive effect found to offer lifetime potency of carcinogenesis upon consumption of these shrimps. Therefore, probabilistic non-carcinogenic human health risk from Fe contamination necessitates stringent monitoring and controlling of this metal from different sources to farms.

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Section: Introductionmentioning

confidence: 99%

Assessment of heavy metals in farmed shrimp, Penaeus monodon sampled from Khulna, Bangladesh: An inimical to food safety aspects

Biswas¹,

Soma²,

Rohani

et al. 2021

Heliyon

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show abstract

“…Various studies have evaluated the effect of pesticides on neurological disorders with Parkinson's disease as one of the major disorders caused by these chemicals [40,43,44]. Increased reactive oxygen species (ROS) levels as a result of pesticide usage and exposure can be associated with imbalances in cell homeostasis, which, in turn, affects cellular components and DNA stability, and causes genotoxicity [42,[44][45][46][47][48][49][50]. A positive correlation between the incidence of various types of cancers such as leukemia, lung, and ovarian cancer as dependent variable and exposure to pesticides has been shown in many studies [13,29,30].…”

Section: Dilemma Of Using Pesticidesmentioning

confidence: 99%

Are insect GPCRs ideal next‐generation pesticides: opportunities and challenges

et al. 2021

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The increasing human population, combined with low inefficiency and adverse effects of available pesticides, has magnified the urgent need of developing next-generation pesticides. Among the available approaches, strategies targeting invertebrate G protein-coupled receptors (GPCRs) are very promising as these receptors are the targets of endogenous neuropeptides/neuromodulators that upon binding to their receptors induce profound changes in insect physiology. Therefore, exploring GPCR regulators has great potential in the development of targeted next-generation pesticides. Despite the great potential of such alternative pesticides, so far there has been only one approved compound, Amitraz, which conveys its antipest activity via the GPCR Octopamine receptor. Here, we review the current status of pesticide development, hazards associated with conventional pesticide compounds, alternative strategies that involve next-generation of pesticides, structural features of GPCRs, and opportunities and challenges of targeting the members of this superfamily in invertebrates to develop anti-pest agents. In conclusion, we emphasize that the potential of GPCRs cannot be utilized in full without more genomic and transcriptomic data to improve our understanding of the complex network of peptidergic signaling pathways. We argue how vital it is to obtain three-dimensional (3D) structural data on physiologically important target GPCRs and encourage the readers to use the state of the art in silico methods such as virtual screening for the discovery of new pesticide compounds.

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“…Деякі автори пов'язують прооксидантну дію пестицидів з генотоксичними ефектами, які виявляються в безхребетних і хребетних тварин (Yadav et al, 2021). Зокрема, показані генотоксичні ефекти синтетичних піретроїдів у тканинах гідробіонтів (Amaeze et al, 2020).…”

Section: вступunclassified

Influence of the Insecticide ?-cyhalothrin on Oxidative Stress and Expression of Replicative Protein A in the Brain of Fish

Nedzvetsky¹,

Gasso²,

Novitskyi³

et al. 2020

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Anthropogenic pollution of natural waters by pesticides became a global problem with the beginning of their widespread use in the 1960s of the twentieth century. The most studied cells’ response to the pesticides is an increase in the content of reactive oxygen species (ROS) and, as a consequence, the development of oxidative stress. The proliferative activity of cells is regulated by various factors and largely depends on the expression of proteins involved in the DNA replication. Among such proteins are replicative proteins A (RPA), which binds single-stranded DNA (ssDNA) of eukaryotes. Disruption of RPA-associated cellular activity initiates genomic imbalance, so the expression and content of RPA1 serves as a marker not only of the cell cycle stability, but also the relevant response to DNA damage caused by ecotoxicants.The aim of our study is to determine the oxidative stress development and the RPA1 protein state as a response of rainbow trout’s brain cells to the influence of sublethal concentrations of the lambda-cyhalothrin. A model experiment on the neurotoxicity of lambda-cyhalothrin was performed on the rainbow trout (Oncorhynchus mykiss) under experimental conditions in a la-boratory. The obtained results indicate that sublethal concentrations of lambda-cyhalothrin in the water induce a significant increase in ROS generation in the rainbow trout’s brain. It was found that the content of ROS in the fish brain in all experimental groups depends on both the lambda-cyhalothrin concentration and the duration of exposure to the pesticide. Oxidative stress under the influence of lambda-cyhalothrin increases the content of stress-regulating protein RPA1 in the fish brain, inhibits transcriptional activity and limits the DNA breaks repair, which, in turn, can lead to genomic instability and activation of apoptosis. This indicates a high sensitivity of the mechanism of DNA replication to the neurotoxic effect of synthetic pyrethroids. Thus, the detected increased expression of RPA1 protein may be an adequate biomarker of cellular response to the toxic effects of synthetic pyrethroids in the brain of fish. Further studies of the effect of pyrethroids on key proteins of the aquatic organisms’ reaction to intoxication are of great importance for the determination of indicative biomarkers of pesticide pollution and its potential risk

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Comparative assessment of the acute toxicity, haematological and genotoxic effects of ten commonly used pesticides on the African Catfish, Clarias gariepinus Burchell 1822

Cited by 35 publications

References 45 publications

Assessment of heavy metals in farmed shrimp, Penaeus monodon sampled from Khulna, Bangladesh: An inimical to food safety aspects

Assessment of heavy metals in farmed shrimp, Penaeus monodon sampled from Khulna, Bangladesh: An inimical to food safety aspects

Are insect GPCRs ideal next‐generation pesticides: opportunities and challenges

Influence of the Insecticide ?-cyhalothrin on Oxidative Stress and Expression of Replicative Protein A in the Brain of Fish

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