Comparative assessment of rest and post-stress left ventricular volumes and left ventricular ejection fraction on gated myocardial perfusion imaging (MPI) and echocardiography in patients with transient ischaemic dilation on adenosine MPI: Myocardial stunning or subendocardial hypoperfusion?

Emmett, Louise; Ng, A.; Ha, Leo; Russo, R; Mansberg, Robert; Zhao, Wei; Chow, S. Vincent; Kritharides, Leonard

doi:10.1007/s12350-012-9571-4

Cited by 31 publications

(11 citation statements)

References 22 publications

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“…35 This supports the present unexpected results regarding both TID ratio and SWMS in the SDI protocol with vasodilator stress. Moreover, if physicians did not need TID ratio or changes of wall motion between stress and rest scan in clinical reading, the second acquisition might not be necessary.…”

Section: Discussionsupporting

confidence: 91%

Clinical Feasibility of Simultaneous Acquisition Rest 99mTc/Stress 201Tl Dual-Isotope Myocardial Perfusion Single-Photon Emission Computed Tomography With Semiconductor Camera

Makita

Matsumoto

Suzuki

et al. 2016

Circ J

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Circulation Journal Official Journal of the Japanese Circulation Society http://www. j-circ.or.jp camera has cadmium-zinc-telluride (CZT) detectors and direct conversion of scintillation without NaI crystal. The CZT gamma camera is also expected to improve image contrast, provide multi-isotope imaging, faster scan and short acquisition time. 9 A novel dedicated cardiac scanner, the D-SPECT (Spectrum Dynamics, Caesarea, Israel), has 9 CZT detectors (40×160 mm) with square-hole tungsten collimators. In our previous experiment, D-SPECT had 1.6-and 1.4-fold better full width at half maximum (FWHM) in both 99 m Tc and 201 Tl line-sources than the conventional anger gamma camera, respectively. Regarding photon count sensitivity, D-SPECT also had 5.03-and 6.31-fold higher photon count · s -1 · MBq -1 tress myocardial perfusion single-photon emission computed tomography (MPS) is the standard diagnostic modality in patients with known or suspected coronary artery disease (CAD). 1-4 Stress-induced myocardial ischemia and left ventricular (LV) functional parameters are markers of future cardiac events. 5-7 Moreover, recent clinical guidelines recommend ≥10% myocardial ischemia in the LV as an indication for coronary revascularization. 8 Precise diagnosis and quantification using MPS would facilitate this.Technical features of the recently developed semiconductor gamma camera include high spatial resolution, high sensitivity and high energy-spectrum resolution. This type of gamma

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Section: Discussionsupporting

confidence: 91%

Clinical Feasibility of Simultaneous Acquisition Rest 99mTc/Stress 201Tl Dual-Isotope Myocardial Perfusion Single-Photon Emission Computed Tomography With Semiconductor Camera

Makita

Matsumoto

Suzuki

et al. 2016

Circ J

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“…While myocardial perfusion can not be directly evaluated by ECHO or invasive CAG, nuclear cardiac imaging tests provide simultaneous assessment of myocardial perfusion and LV function (24,27). So, defining true myocardial ischemia on the basis of transient regional wall motion abnormalities related to ischemic LV dysfunction is possible (28,29). The good agreement between stress ECHO and gated MPS studies has been reported regarding segmental wall motion analysis (25).…”

Section: Discussionmentioning

confidence: 99%

The Role of Myocardial Perfusion Gated SPECT Study in Women with Coronary Artery Disease: A Correlative Study

Akalın

Yaylalı²,

Kıraç³

et al. 2012

MIRT

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Objective: We aimed to evaluate the role of gated myocardial perfusion SPECT (MPS) and to investigate whether only the invasive coronary angiography (CAG) is sufficient in the diagnosis of the coronary artery disease (CAD) in women. Material and Methods: Sixty-four women (62±10 years) with known CAD were included in this study. They had echocardiography (ECHO), stress/rest gated MPS and invasive CAG. Coronary stenosis as of > 50 % in invasive CAG was accepted as significant. Gated MPS data were compared with invasive CAG and ECHO. Results: Invasive CAG results were abnormal in 34 patients, and normal in 30 cases. Myocardial ischemia was detected by gated MPS in 22/ 30 cases with normal invasive CAG, 6 had mild coronary stenosis in major coronary arteries ranging from 30% to 50% in invasive CAG. 16/ 22 women were diagnosed as metabolic syndrome according to MetSend Diagnostic Criteria and only 8 of 30 patients with normal invasive CAG had false positive MPS data on the reevaluation by a nuclear cardiologist.Conclusion: We think that invasive coronary angiography method is not sufficient alone in the diagnosis of CAD in women. Gated MPS study is recommended to achieve the final decision for myocardial ischemia in the cases with CAD and raw data must always be evaluated to avoid attenuation artifacts. Conflict of interest:None declared.

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“…This rare occurrence is likely to also manifest through other markers of poor prognosis such as high percentage of ischemic myocardium on imaging, transient ischemic dilatation, and low poststress ejection fraction. 21,22 Indeed, these strong predictors of risk may reduce the prognostic power of vasodilatorinduced hypotension on multivariate analysis as suggested by the findings of Witbrodt et al 8 Further, since the majority of patients will experience a drop in BP with vasodilator stress due to direct peripheral vasodilation, it becomes difficult if not impossible to distinguish those who experience a drop of BP due to ischemia from the normal response. In contrast, an abnormal heart rate response to vasodilator stress, i.e., a blunted response, runs directionally opposite to the normal response seen in the majority of patients, a brisk increase in heart rate.…”

Section: Blood Pressure Response To Vasodilator Stressmentioning

confidence: 99%

The blood pressure response to vasodilator stress does not provide independent prognostic information

Reyes

Hage

2017

Journal of Nuclear Cardiology

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Comparative assessment of rest and post-stress left ventricular volumes and left ventricular ejection fraction on gated myocardial perfusion imaging (MPI) and echocardiography in patients with transient ischaemic dilation on adenosine MPI: Myocardial stunning or subendocardial hypoperfusion?

Abstract: Transient dilation of the left ventricle on adenosine MPI is not related to chamber enlargement and myocardial stunning, but is more likely a function of subendocardial hypoperfusion and impaired coronary flow reserve.

Cited by 31 publications

References 22 publications

Clinical Feasibility of Simultaneous Acquisition Rest <sup>99m</sup>Tc/Stress <sup>201</sup>Tl Dual-Isotope Myocardial Perfusion Single-Photon Emission Computed Tomography With Semiconductor Camera

Clinical Feasibility of Simultaneous Acquisition Rest <sup>99m</sup>Tc/Stress <sup>201</sup>Tl Dual-Isotope Myocardial Perfusion Single-Photon Emission Computed Tomography With Semiconductor Camera

The Role of Myocardial Perfusion Gated SPECT Study in Women with Coronary Artery Disease: A Correlative Study

The blood pressure response to vasodilator stress does not provide independent prognostic information

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