Comparative assessment of periodontal regeneration in periodontal intraosseous defects treated with PepGen P-15 unaided or in blend with platelet-rich fibrin: A clinical and high-resolution computed tomography scan-assisted volumetric analysis

Goyal, Jyotsna; Sachdeva, Surinder; Salaria, Sanjeev Kumar; Vakil, Nishu; Mittal, Amit

doi:10.4103/jisp.jisp_351_19

Cited by 6 publications

(4 citation statements)

References 29 publications

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“…Regenerative therapies, such as enamel matrix derivative product application, guided tissue regeneration, bone grafting or biomolecular techniques, are also used [57,63,64]. For this purpose, many different materials are used, including demineralized freeze-dried bone allografts (DFDBA), autogenic bone, alloplastic materials or xenogenic materials, such as anorganic bovine bone mineral (ABBM), which is a material that is produced by removing organic components from cortical or spongy bovine bone [54,57,60].…”

Section: Prp and Prf In Intrabony Defect Treatmentmentioning

confidence: 99%

PRP and PRF—Subgroups and Divisions When Used in Dentistry

Pietruszka

Chruścicka

Duś-Ilnicka

et al. 2021

JPM

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Blood derivates, such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), are autogenous sources of many growth factors that are involved in the healing and regeneration of tissues, and for this reason, are used in dentistry treatments. This fact also contributes to the growing interest in these biomaterials in regenerative personalized medicine. The multitude of platelet-rich forms creates many possibilities for their use. This semi-systematic review describes and compares the methods of obtaining properties and potential uses of these materials in personalized treatments.

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Section: Prp and Prf In Intrabony Defect Treatmentmentioning

confidence: 99%

PRP and PRF—Subgroups and Divisions When Used in Dentistry

Pietruszka

Chruścicka

Duś-Ilnicka

et al. 2021

JPM

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“…In the present study, the radiographic parameters were assessed through CBCT, as it allows three-dimensional assessment and volumetric analysis which may depict a better representation of an intrabony defect than linear measurements, and could be an effective alternative for the surgical re-entry [ Figure 3b - d and 4b - d ]. [ 20 21 22 23 ] A significant gain in the bone volume ( P ≤ 0.05) and a highly significant defect fill ( P ≤ 0.001), defect resolution ( P ≤ 0.001) was observed in group A as compared to group B at 6 months post operatively. Our radiographic results are in agreement with the studies done by Elegandy et al,[ 18 ] Kasaj et al[ 12 ] and Pradeep et al[ 20 ]…”

Section: Discussionmentioning

confidence: 96%

Clinicoradiographic evaluation of advanced-platelet rich fibrin block (A PRF + i PRF + nanohydroxyapatite) compared to nanohydroxyapatite alone in the management of periodontal intrabony defects

Mallappa

Vasanth

Gowda

et al. 2022

Journal of Indian Society of Periodontology

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Background: Several bone grafting formulations have been given clinically acceptable outcomes in treating intrabony defects. Platelet rich fibrin (PRF), an autologous platelet concentrate holds potential to be used for regenerative treatment. The purpose of this study was to evaluate clinical and radiographic outcomes in periodontal intrabony defects treated with advanced-PRF block (A PRF + i PRF + nanohydroxyapatite [nHA]) compared to nHA alone. Methods: Twenty-eight sites in chronic periodontitis patients having probing pocket depth (PPD) ≥6 mm and 3 walled intrabony defects (depth of ≥3 mm) were selected, randomly allotted into two groups: Group A was treated with A-PRF block and Group B with nHA (Sybograf™). Clinical parameters including plaque index (PI), gingival index (GI), PPD, relative attachment level (RAL) and radiographically linear and volumetric defect fill were assessed using cone beam computed tomography at baseline and 6 months postoperatively. Results: Intragroup comparison using paired t-test and intergroup comparison using unpaired t-test was done. Group A demonstrated significantly higher reduction in PPD and gain in RAL when compared to Group B (P ≤ 0.05) at the end of 6 months. Similarly gain in bone volume was greater in Group A (0.1 ± 0.05) as compared to Group B (0.04 ± 0.02) (P ≤ 0.05). Conclusion: Advanced-PRF block showed significant clinical and radiographic improvement as compared to nHA alone which depicts that, it may be an ideal graft to be used for the treatment of periodontal intrabony defects.

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“…Four RCTs evaluated the benefit of combining a xenograft with L‐PRF 146–149 . They all reported significantly more gain in the attachment (0.9–1.2 mm) and intra‐bony defect depth reduction (11%) when L‐PRF was mixed with the xenograft.…”

Section: Do Apcs Play a “Significant” Role In Bone Regeneration?mentioning

confidence: 99%

Do autologous platelet concentrates (APCs) have a role in intra‐oral bone regeneration? A critical review of clinical guidelines on decision‐making process

Quirynen,

Siawasch,

Temmerman

et al. 2023

Periodontology 2000

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In the past decades, personalized regenerative medicine has gained increased attention. Autologous platelet concentrates (APCs) such as PRP, PRGF, and L‐PRF, all serving as a source of a large variety of cells and growth factors that participate in hard and soft tissue healing and regeneration, could play a significant role in regenerative periodontal procedures. This narrative review evaluated the relative impact of APCs in alveolar ridge preservation, sinus floor augmentation, and the regeneration of bony craters around teeth, both as a single substitute or in combination with a xenograft. L‐PRF has a significant beneficial effect on alveolar ridge preservation (<alveolar bone resorption, >bone quality). The data for PRGF are less convincing, and PRP is controversial. L‐PRF can successfully be used as a single substitute during transcrestal (≥3.5 mm bone gain) as well as 1‐stage lateral window sinus floor elevation (>5 mm bone gain). For PRGF and especially PRP the data are very scarce. In the treatment of bony craters around teeth, during open flap debridement, L‐PRF as a single substitute showed significant adjunctive benefits (e.g., >PPD reduction, >CAL gain, >crater depth reduction). The data for PRP and PRGF were non‐conclusive. Adding PRP or L‐PRF to a xenograft during OFD resulted in additional improvements (>PPD reduction, >CAL gain, >bone fill), for PRGF no data were found. Autologous platelet concentrates demonstrated to enhance bone and soft tissue healing in periodontal regenerative procedures. The data for L‐PRF were most convincing. L‐PRF also has the advantage of a greater simplicity of production, and its 100% autologous character.

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Comparative assessment of periodontal regeneration in periodontal intraosseous defects treated with PepGen P-15 unaided or in blend with platelet-rich fibrin: A clinical and high-resolution computed tomography scan-assisted volumetric analysis

Cited by 6 publications

References 29 publications

PRP and PRF—Subgroups and Divisions When Used in Dentistry

PRP and PRF—Subgroups and Divisions When Used in Dentistry

Clinicoradiographic evaluation of advanced-platelet rich fibrin block (A PRF + i PRF + nanohydroxyapatite) compared to nanohydroxyapatite alone in the management of periodontal intrabony defects

Do autologous platelet concentrates (APCs) have a role in intra‐oral bone regeneration? A critical review of clinical guidelines on decision‐making process

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