Comparative assessment of fungicidal activity of widespread wild-growing and endemic species of the Allium genus growing in Tajikistan

Mirzoeva, Fazila; Satorov, S.

doi:10.52888/0514-2515-2021-350-55-61

Cited by 3 publications

(1 citation statement)

References 8 publications

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“…Одной из проблем современного фармацевтического рынка является недостаточный арсенал и малая эффективность лекарственных препаратов, против патогенных для человека бактерий и вирусов. Другой, не менее важной, составляющей этой проблемы является лекарственная устойчивость патогенных агентов, связанная с возникновением у микроорганизмов резистентности к применяемым препаратам, что приводит к снижению или полной потере эффективности лекарственной терапии и, соответственно, к необходимости поиска новых медикаментозных средств [3,11].…”

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Antiviral effect of the Ferula Kuhistanica Korovin plant, growing in the high-mountain conditions of the Republic of Tajikistan

Satorov,

Mavlonazarova,

Yusufi

2023

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This work presents the results of studies on the extract obtained from the root of Ferula kuhistanica Korov, in relation to 2 strains of the influenza virus: A/Vlad/2/09(H1N1) and A/Almaty/8/98(H3N2). It has been shown that the F. kuhistanica Korov extract exhibits selective antiviral activity and primarily acts on the influenza virus strain A/Vlad/2/09(H1N1), not showing an inhibitory effect against another antigenic variant of this virus – the strain A/ Almaty/8/98(H3N2). The tested extract was characterized by high IC50, EC50, and IS50 indicators. Its chemotherapeutic effect (XTI) is 23 times higher than that of the commercial anti-influenza drug - Tamiflu. The data obtained open up prospects for the possible use of extracts obtained from the root of various species of the genus Ferula, growing in our country, in the development of anti-influenza drugs.

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Antiviral effect of the Ferula Kuhistanica Korovin plant, growing in the high-mountain conditions of the Republic of Tajikistan

Satorov,

Mavlonazarova,

Yusufi

2023

jour

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Analysis of Antibacterial and Fungicidal Activity of Allium Oshaninii and Allium Suworowii Depending on the Altitude of Plant Growth

Mirzoeva¹

2022

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Objective: To study the biological properties of plants of the genus Allium and their correlation with antimicrobial and fungicidal activity depending on the altitude of plant growth. Methods: Seeds, leaves and bulbs of widespread wild and endemic species of the genus Allium growing in various regions of the Republic of Tajikistan were the objects of the study. The antimicrobial activity of the obtained extracts was studied against standard museum microorganisms (test strains): Staphylococcus aureus (ATCC 4929), Pseudomonas aeruginosa (ATCC 4930), Klebsiella pneumoniae (ATCC 4927), Escherichia coli (ATCC 4928). Antifungal activity was studied against Candida species. Results: Correlation of varying strength was discovered between the content of biocomponents with antimicrobial and fungicidal activity, the altitude of plant growth and place of its collection. The content of total polyphenols and the antioxidant activity of extracts obtained from various parts of the plants varied over a wide range. In some cases, there were direct correlations of varying strength between the content of polyphenols, antioxidative, antimicrobial and fungicidal properties of the plants. Conclusion: This study showed the insignificant correlations between the content of biocomponents and antimicrobial, and fungicidal properties of the studied types of onions, which did not depend on the growing zone. Keywords: Onion, plant, growth inhibition, extract, reference bacterial strains.

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Surgical Treatment of Inguinal Hernia Combined With Cryptorchidism

MALIKOV¹,

KHAMIDOV²,

BOKIEV³

et al. 2022

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Objective: To evaluate outcomes of single-stage surgery performed for inguinal hernia combined with cryptorchidism. Methods: Between 2005 and 2020, 22 patients aged 3 to 28 years underwent surgery for inguinal hernias combined with cryptorchidism. All surgeries were performed using instrumentation, affording surgical precision through enhanced visualisation and magnification. The combination of the hernia with cryptorchidism was noted in 12 (54.5%) and 8 (36.4%) patients on the right and left sides, respectively. In addition, bilateral localisation of hernia and cryptorchidism was observed in 2 (9.1%) patients. In addition to clinical investigation, ultrasonography (US), Doppler ultrasonography (DU) and, to a limited extent, computed tomography (CT) were used preoperatively and in the long-term postoperative period. Dynamical changes in the threedimensional testicular measurements, testicular volumes and the time-averaged maximum velocity (TAMAX, cm/s) in the testicular arteries were evaluated. Results: In the immediate postoperative period, seroma formation and suppuration of wounds were not noted. However, in 3 (13.6%) cases, transient swelling of the scrotum was observed. According to ultrasound data, 6 months after single-stage operations, there was a statistically significant increase in all parameters of the operated testicle compared to the initial values, including three-dimensional testicular measurements and volume (p<0.05) in all age groups. In addition, 6 months after the operation, the sizes of surgically brought down and healthy testicles in all age groups became equal, except for the thickness of the testis in children aged 3-5 years. At the same time, according to DU data, there was also a statistically significant increase in TAMAX in the testicular artery on the side of the lesion (p<0.001). Conclusion: The use of instrumentation, affording surgical precision through enhanced visualisation and magnification when performing surgery for inguinal hernia and cryptorchidism, is the gold standard treatment. Because it prevents iatrogenic damage to critical anatomical structures, allows maximum mobilisation of the vascular pedicle of the retained testicle and contributes to the safe bringing down of the latter without much tension. The selection of an appropriate hernial orifice reconstruction method, along with the recurrence prevention, also helps to avoid compression of the elements of the spermatic cord and thus improve the fertile function. Keywords: Inguinal hernia, cryptorchidism, a combination of inguinal hernia and cryptorchidism.

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Comparative assessment of fungicidal activity of widespread wild-growing and endemic species of the Allium genus growing in Tajikistan

Cited by 3 publications

References 8 publications

Antiviral effect of the Ferula Kuhistanica Korovin plant, growing in the high-mountain conditions of the Republic of Tajikistan

Antiviral effect of the Ferula Kuhistanica Korovin plant, growing in the high-mountain conditions of the Republic of Tajikistan

Analysis of Antibacterial and Fungicidal Activity of Allium Oshaninii and Allium Suworowii Depending on the Altitude of Plant Growth

Surgical Treatment of Inguinal Hernia Combined With Cryptorchidism

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