Comparative assessment of efficacy of two different pretreatment single oral doses of betamethasone on inter-appointment and postoperative discomfort: An in vivo clinical evaluation

Abstract

Aim:Study aimed to evaluate the efficacy of two different pretreatment single oral doses of betamethasone on the incidence of inter-appointment flare up and postoperative discomfort.Materials and Methods:Fifty-four patients aged 18–59 years requiring endodontic treatment were selected and randomly assigned to three groups; single pretreatment oral dose of placebo or betamethasone in two different oral doses of 0.5 mg and 1 mg, respectively. Endodontic therapy was completed in two visits using triple antibiotic paste as intracanal medicament. Patients were given a questionnaire to record their pain at 1, 2, 3, and 7 days after treatment. In the second visit, obturation was done, and the patients were again instructed to record their pain scores after treatment and discharged. The verbal rating scale was used for recording the pain scores. Statistical analysis was done using ANOVA and the Friedman test.Results:0.5 mg betamethasone group showed least mean pain scores among all experimental groups; however, there was no statistically significant difference between any of the groups (P > 0.05).Conclusion:Pretreatment single oral dose of betamethasone is an effective in managing endodontic flare-ups; however, the results were statistically insignificant.

Nonclinical research areas of future importance for clinical therapies: Exploring the concepts of nonlinearity in dentistry

“…[ 8 ] Although some factors such as over-instrumentation and apical extrusion of bacteria have been suggested as contributing, the exact mechanism of flare-ups is unknown, and anecdotal evidence shows that it can happen even with a careful instrumentation technique. [ 9 10 11 ] The following hypothetical scenario can be used to better grasp the unpredictability of endodontic flare-ups: root canal treatment is performed on two contralateral mandibular bicuspids on the same patient. The initial pulpal and periapical diagnosis for both premolars is pulp necrosis with asymptomatic apical periodontitis, and the endodontic treatment is performed by the same clinician with the clinician using identical techniques.…”

Comparison of Calcium Hydroxidea and Triple Antibiotic Paste on Inter-Appointment Endodontic Pain

“…Anticipation and experience of root canal associated pain is a major source of fear for patients and a very important concern of dentists 1 . The International Associates for the Study of Pain has defined pain as: "an unpleasant sensory and emotional experience associated with actual or potential damage or described in terms of such damage" 2 .…”

Comparative evaluation of the efficacy of diclofenac sodium administered using different delivery routes in the management of endodontic pain: A randomized controlled clinical trial

“…[ 5 ] Overinstrumentation, periapical extrusion of irrigant/medicament, and restoration in hyperocclusion are chief causes that often provoke an acute inflammatory response, resulting in a mid-treatment flare-up. [ 4 6 7 8 ] Anti-inflammatory analgesics, systemic steroids, and anxiolytics are few of the commonly used preoperative drugs used during endodontic practice. [ 9 ] Pretreatment analgesia has been defined as an antinociceptive treatment that prevents altered processing of afferent input amplifying postoperative pain.…”