Comparative Assessment of Drug Drug Interactions Among Public and Private Sector Hospitals

Butt, Hammad Ahmed; Anwar, Muhammad Zeeshan; Shahzad, Akram; Khan, Aslam; Aslam, Hina; Ashraf, Anum; Laique, Talha

doi:10.53350/pjmhs211551002

Cited by 1 publication

(1 citation statement)

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“…Healthcare professionals need to pay more attention while managing patients with chronic diseases due to the significant effects of these interactions on the patient’s health and its economic burden on the healthcare system [ 37 ]. Pakistan, being a developing country, the patients receiving healthcare at hospitals exposes patients to potential risks of pDDIs and other adverse or iatrogenic effects due to overburdened, loss of follow-up and no facility available for scanning of pDDIs on spot for the patients [ 38 ]. This study compared the incidence of pDDIs between a public hospital (run by the government) and a private hospital among CKD patients.…”

Section: Discussionmentioning

confidence: 99%

Comparative analysis of potential drug-drug interactions in a public and private hospital among chronic kidney disease patients in Khyber Pakhtunkhwa: A retrospective cross-sectional study

Zafar,

Rehman,

Shah

et al. 2023

PLoS ONE

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Introduction Chronic kidney disease (CKD) is a significant public health challenge due to its rising incidence, mortality, and morbidity. Patients with kidney diseases often suffer from various comorbid conditions, making them susceptible to potential drug-drug interactions (pDDIs) due to polypharmacy and multiple prescribers. Inappropriate prescriptions for CKD patients and their consequences in the form of pDDIs are a major challenge in Pakistan. Aim This study aimed to compare the incidence and associated risk factors of pDDIs among a public and private sector hospital in Khyber Pakhtunkhwa, Pakistan. Method A retrospective cross-sectional study design was conducted to compare pDDIs among public and private sector hospitals from January 2023 to February 2023. Patients profile data for the full year starting from January 1 2022 to December 302022, was accessed All adult patients aged 18 years and above, of both genders, who currently have or have previously been diagnosed with end-stage renal disease (ESRD) were included. For assessing pDDIs, patient data was retrieved and checked using Lexicomp UpToDate® for severity and documentation of potential drug-drug interactions. Results A total of 358 patients’ data was retrieved (with n = 179 in each hospital); however, due to incomplete data, n = 4 patients were excluded from the final analysis. The prevalence of pDDIs was found to be significantly higher in private hospitals (84.7%) than in public hospitals (26.6%), with a p-value <0.001. Patients in the age category of 41–60 years (AOR = 6.2; p = 0.008) and those prescribed a higher number of drugs (AOR = 1.2; p = 0.027) were independently associated with pDDIs in private hospitals, while the higher number of prescribed drugs (AOR = 2.9; p = <0.001) was an independent risk factor for pDDIs in public hospitals. The majority of pDDIs (79.0%) were of moderate severity, and a significant number of patients (15.1%) also experienced major pDDIs, with a p-value <0.001. The majority of pDDIs had fair documentation for reliability rating in both public and private hospitals. Conclusion The prevalence of pDDIs was higher among CKD patients at private hospitals, and most of the pDDIs were of moderate severity. A considerable number of patients also experienced major pDDIs. The risk of experiencing pDDIs was found to be higher in older patients and among those prescribed a higher number of drugs.

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Section: Discussionmentioning

confidence: 99%