Comparative assessment of cardiovascular risk in European and Korean ethnic groups in the Russian population using the SCORE and SCORE2

Bogdanov, D. Yu.; Невзорова, В. А.; Shestopalov, E. Yu.

doi:10.15829/1728-8800-2022-3128

Cited by 3 publications

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References 16 publications

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“…В русскоязычной литературе недавно опубликована первая попытка сравнения ССР по шкалам SCORE и SCORE2 у 397 лиц 40-49 лет европейской и корейской этнических принадлежностей, объединенных единой территорией проживания [16]. Согласно данным шкалы SCORE2 более половины участников корейской этнической группы в возрасте 40-49 лет уже имели очень высокий ССР, что значимо отличает данную группу от популяции европейцев.…”

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Appointment of lipid-lowering therapy in the Russian population: comparison of SCORE and SCORE2 (according to the ESSE-RF study)

et al. 2022

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Aim. In 2021, the European Society of Cardiology (ESC) guidelines for the prevention of cardiovascular diseases (CVDs) were published, where a new SCORE2 CVD risk assessment model was introduced. In our work, we compared approaches to determine the indications for initiating lipid-lowering therapy in the Russian population aged 25-64 years according to the guidelines for the diagnosis and treatment of lipid metabolism disorders of the Russian National Atherosclerosis Society (2020) and ESC guidelines for CVD prevention (2021).Material and methods. The ESSE-RF epidemiological study was conducted in 12 Russian regions. All participants signed informed consent and completed approved questionnaires. We performed anthropometric and blood pressure (BP) measurements, as well as fasting blood sampling. In total, 20665 people aged 25-64 years were examined. The analysis included data from 19546 respondents (women, 12325 (63,1%)).Results. Of the 19546 participants, 3828 (19,6%) were classified as high or very high CV risk based on the 9 criteria: BP ≥180/110 mm Hg, total cholesterol >8,0 mmol/l, low-density lipoprotein (LDL) >4,9 mmol/l, lipid-lowering therapy, chronic kidney disease (CKD) with glomerular filtration rate <60 ml/min/1,73 m2, type 2 diabetes, previous stroke and/or myocardial infarction. Of 3828 people, lipidlowering therapy was indicated in 3758 (98%) (criteria for LDL ≥1,8 mmol/l and LDL ≥1,4 mmol/l, respectively, high and very high risk). In addition, 5519 individuals aged <40 years were excluded from further analysis due to the lower age threshold of models. For 10199 participants aged >40 years without established CVD, diabetes, CKD, cardiovascular risk stratification was performed according to the SCORE and SCORE2. Of them, according to the Russian National Atherosclerosis Society (2020) and ESC 2021 guidelines, lipid-lowering therapy was indicated for 701 and 9487 participants, respectively.Conclusion. Using the new approach proposed by the ESC in 2021, the number of patients aged 40-64 years without CVD, diabetes and CKD with indications for lipidlowering therapy for primary prevention in Russia increases by 14 times compared with the 2020 Russian National Atherosclerosis Society guidelines.

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Appointment of lipid-lowering therapy in the Russian population: comparison of SCORE and SCORE2 (according to the ESSE-RF study)

et al. 2022

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CarotidSCORE.RU — risk stratification for complications after carotid endarterectomy

et al. 2022

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Aim. To demonstrate the first Russian computer program (carotidscore.ru) for risk stratification of postoperative complications of carotid endarterectomy (CE).Material and methods. The present study is based on the analysis of a multicenter Russian database including 25812 patients after CE operated on from January 1, 2010 to April 1, 2022. The following types of CE were implemented: conventional CE with patch angioplasty — 6814 patients; eversion CE — 18998 patients. Following postoperative complications were assessed during the study: death, stroke, myocardial infarction (MI), composite endpoint (death + stroke + MI).Results. During inhospital postoperative period, 0,18% of participants died, while 0,14% had MI, 0,35% — stroke. The composite endpoint was recorded in 0,68%. For each factor present in patients, a predictive coefficient was estimated. The predictive coefficient was considered as a numerical parameter reflecting the strength of the effect of each factor on the development of postoperative complications. Based on this equation, predictive coefficients were calculated for each factor present in patients in our study. The total contribution of these factors was reflected as a percentage and denoted the risk of postoperative complications with a minimum of 0% and a maximum of 100%. On the basis of obtained calculations, a CarotidSCORE program was created. Its graphical interface is based on the QT framework. It is possible not only to estimate the risk of a complication, but also to save all data about a patient in JSON format. The CarotidSCORE program contains 47 patient parameters, including clinical, demographic, anamnestic and angiographic characteristics. It makes it possible to choose one of the four CE types, which will provide an accurate stratification of the complication risk for each of them.Conclusion. CarotidSCORE (carotidscore.ru) may determine the probability of postoperative complications in patients undergoing CE.

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Mathematical model possibility of the risk of developing atherosclerosis among 30–49 years old of Slavic and Korean population

Bogdanov

Невзорова

Shakhgeldyan

et al. 2022

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The research purpose: development of a mathematical model for predicting the risk of carotid atherosclerosis in young adults 30-49 years old of Slavic and Korean ethnicity.Materials and methods. 136 conditionally healthy people of Slavic (n-84) and Korean ethnicity (n-52) were evaluated. The survey was conducted according to the design of ESSE-RF study. A carotid arteries duplex scan has been conducted. The predictive model was developed using the logistic regression method.Results. Ethnic groups did not differ among themselves in terms of age, smoking prevalence and gender (p > 0.05). In KEG increased levels of apoB containing lipoproteins was revealed (level non-HDL-C in KEG was 5,0 ± 1,1 mmol/l versus 4.0 ± 0.9 mmol/l in SEG (p < 0,001), HDL and apoA did not differ between groups (p > 0,05).The prevalence atherosclerosis of the CA was 28.6% in SEG and 32.7% in KEG (p > 0,05). In average KEG had more pronounced atherosclerotic process in the CAthe total percentage of stenosis in the SEG 40 [20; 50] % vs 51 [29; 59] % in KEG, p =0,044, and the average % of stenoses is 22.5 [20; 25] % versus 25.5 [24.6; 29] % respectively, p = 0.029.Binary logistic regression method was used for developing a predictive model for determine the risk of developing carotid atherosclerosis, the area under the ROC curve was 0.848 ± 0.040 with 95% CI: 0.769–0.927. The model was statistically significant, p < 0,001.Conclusion. Above referenced model makes it possible to evaluate with high accuracy the risk of developing carotid atherosclerosis on a standard dispensary appointment basis.

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Comparative assessment of cardiovascular risk in European and Korean ethnic groups in the Russian population using the SCORE and SCORE2

Cited by 3 publications

References 16 publications

Appointment of lipid-lowering therapy in the Russian population: comparison of SCORE and SCORE2 (according to the ESSE-RF study)

Appointment of lipid-lowering therapy in the Russian population: comparison of SCORE and SCORE2 (according to the ESSE-RF study)

CarotidSCORE.RU — risk stratification for complications after carotid endarterectomy

Mathematical model possibility of the risk of developing atherosclerosis among 30–49 years old of Slavic and Korean population

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