Comparative Aspects of Structure and Function of Cnidarian Neuropeptides

Takahashi, Toshio

doi:10.3389/fendo.2020.00339

Cited by 29 publications

(21 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In parallel, different cells in early metazoans also used peptides as signal molecules for slower, more specific, and coordinated regenerative, morphogenic and behavioural responses-which therefore act similarly to extant neuropeptides and morphogenic factors in cnidarians or bilaterians [142].…”

Section: Adaptive Injury/regeneration Signalling As Generalizing Neurogenic Factors In Evolutionmentioning

confidence: 99%

Neural versus alternative integrative systems: molecular insights into origins of neurotransmitters

Moroz

Romanova

Kohn

2021

Phil. Trans. R. Soc. B

113

View full text Add to dashboard Cite

Transmitter signalling is the universal chemical language of any nervous system, but little is known about its early evolution. Here, we summarize data about the distribution and functions of neurotransmitter systems in basal metazoans as well as outline hypotheses of their origins. We explore the scenario that neurons arose from genetically different populations of secretory cells capable of volume chemical transmission and integration of behaviours without canonical synapses. The closest representation of this primordial organization is currently found in Placozoa, disk-like animals with the simplest known cell composition but complex behaviours. We propose that injury-related signalling was the evolutionary predecessor for integrative functions of early transmitters such as nitric oxide, ATP, protons, glutamate and small peptides. By contrast, acetylcholine, dopamine, noradrenaline, octopamine, serotonin and histamine were recruited as canonical neurotransmitters relatively later in animal evolution, only in bilaterians. Ligand-gated ion channels often preceded the establishment of novel neurotransmitter systems. Moreover, lineage-specific diversification of neurotransmitter receptors occurred in parallel within Cnidaria and several bilaterian lineages, including acoels. In summary, ancestral diversification of secretory signal molecules provides unique chemical microenvironments for behaviour-driven innovations that pave the way to complex brain functions and elementary cognition. This article is part of the theme issue ‘Basal cognition: multicellularity, neurons and the cognitive lens'.

show abstract

Section: Adaptive Injury/regeneration Signalling As Generalizing Neurogenic Factors In Evolutionmentioning

confidence: 99%

Neural versus alternative integrative systems: molecular insights into origins of neurotransmitters

Moroz

Romanova

Kohn

2021

Phil. Trans. R. Soc. B

113

View full text Add to dashboard Cite

show abstract

“…It can be noted that an LK-like peptide sequence (Nlp43: KQFYAWAamide) has been identified in nematodes such as C. elegans [ 70 ] (see Figure 1 ), but it is not derived from a canonical LK precursor and no LKR could be found [ 3 , 15 ]. Furthermore, LK signaling components are not found in cnidarians (see [ 71 , 72 ]) or flatworms (Platyhelminthes) [ 73 ]. In lower bilaterians, such as species of Xenoturbella and Nemertodermatid worms (both phylum Xenacoelomorpha), orthologs of LK-type receptors were detected by bioinformatics, but no LK peptides [ 74 ].…”

Section: Leucokinins and Their Receptors In Invertebratesmentioning

confidence: 99%

Leucokinins: Multifunctional Neuropeptides and Hormones in Insects and Other Invertebrates

Nässel

2021

IJMS

View full text Add to dashboard Cite

Leucokinins (LKs) constitute a neuropeptide family first discovered in a cockroach and later identified in numerous insects and several other invertebrates. The LK receptors are only distantly related to other known receptors. Among insects, there are many examples of species where genes encoding LKs and their receptors are absent. Furthermore, genomics has revealed that LK signaling is lacking in several of the invertebrate phyla and in vertebrates. In insects, the number and complexity of LK-expressing neurons vary, from the simple pattern in the Drosophila larva where the entire CNS has 20 neurons of 3 main types, to cockroaches with about 250 neurons of many different types. Common to all studied insects is the presence or 1–3 pairs of LK-expressing neurosecretory cells in each abdominal neuromere of the ventral nerve cord, that, at least in some insects, regulate secretion in Malpighian tubules. This review summarizes the diverse functional roles of LK signaling in insects, as well as other arthropods and mollusks. These functions include regulation of ion and water homeostasis, feeding, sleep–metabolism interactions, state-dependent memory formation, as well as modulation of gustatory sensitivity and nociception. Other functions are implied by the neuronal distribution of LK, but remain to be investigated.

show abstract

“…It can be noted that in nematodes like C. elegans an LK-like peptide sequence (Nlp43: KQFYA-WAamide) has been identified [67] (see Figure 1), but it is not derived from a canonical LK precursor and no LKR could be found [3,15]. Furthermore, LK signaling components are not found in cnidarians [see [68,69]], or flatworms (Platyhelminthes) [70]. In lower bilaterians, like species of Xenoturbella and Nemertodermatid worms (both phylum Xenacoelomorpha), orthologs of LK-type receptors were detected by bioinformatics, but no LK peptides [71].…”

Section: Leucokinins and Their Receptors In Insects And Other Invertementioning

confidence: 99%

Leucokinins: Multifunctional Neuropeptides and Hormones in Insects and Other Invertebrates

Nässel¹,

Wu²

2021

Preprint

View full text Add to dashboard Cite

Leucokinins (LKs) constitute a neuropeptide family first discovered in a cockroach and later identified in numerous insects and several other invertebrates. The LK receptors are only distantly related to other known receptors. Among insects, there are many examples of species where genes encoding LKs and their receptors are absent. Furthermore, genomics has revealed that LK signaling is lacking in several of the invertebrate phyla and in vertebrates. In insects, the number and complexity of LK expressing neurons vary, from the simple pattern in the larva of Drosophila where the entire CNS has 20 neurons of three main types, to cockroaches with about 250 of many different types. Common to all studied insects is the presence or 1-3 pairs of LK-expressing neurosecretory cells in each abdominal neuromere of the ventral nerve cord, that, at least in some insects, regulate secretion in Malpighian tubules. This review summarizes the diverse functional roles of LK signaling in insects, as well as other arthropods and mollusks. These functions include regulation of ion and water homeostasis, feeding, sleep-metabolism interactions, state-dependent memory formation, as well as modulation of gustatory sensitivity and nociception. Other functions are implied by the neuronal distribution of LK, but remain to be investigated.

show abstract

Comparative Aspects of Structure and Function of Cnidarian Neuropeptides

Cited by 29 publications

References 87 publications

Neural versus alternative integrative systems: molecular insights into origins of neurotransmitters

Neural versus alternative integrative systems: molecular insights into origins of neurotransmitters

Leucokinins: Multifunctional Neuropeptides and Hormones in Insects and Other Invertebrates

Leucokinins: Multifunctional Neuropeptides and Hormones in Insects and Other Invertebrates

Contact Info

Product

Resources

About