Comparative Antilipidemic Effects of Native and Gemmotreated Withania Somnifera (Asghand) Extracts

Khursheed, Fouzia; Khalil-ur-Rehman, .; Akhtar, Muhammad Shoaib; Dogar, M. Zahoor-ul-Hassan; Khalil, Bilal

doi:10.21065/19204159.2.47

Cited by 3 publications

(2 citation statements)

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“…Gemmomodified extract of Terminalia arjuna was prepared by maceration process. The fresh plant material was blended in a mixture of alcohol and glycerin having 2 : 1 ratio for 21 days [ 17 ]. Aqueous extract of Piper nigrum was prepared by boiling the plant material with water for ten minutes and filtrate was used.…”

Section: Methodsmentioning

confidence: 99%

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Cardioprotective Potential of Polyphenolic Rich Green Combination in Catecholamine Induced Myocardial Necrosis in Rabbits

Zafar

Jahan

Khalil-ur-Rahman

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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The present study was designed to develop safer, effective, and viable cardioprotective herbal combination to control oxidative stress related cardiac ailments as new alternatives to synthetic drugs. The synergetic cardioprotective potential of herbal combination of four plants T. arjuna (T.A.), P. nigrum (P.N), C. grandiflorus (C), and C. oxyacantha (Cr) was assessed through curative and preventive mode of treatment. In preventive mode of treatment, the cardiac injury was induced with synthetic catecholamine (salbutamol) to pretreated rabbits with the proposed herbal combination for three weeks. In curative mode of treatment, cardiotoxicity/oxidative stress was induced in rabbits with salbutamol prior to treating them with plant mixture. Cardiac marker enzymes, lipids profile, and antioxidant enzymes as biomarker of cardiotoxicity were determined in experimental animals. Rabbits administrated with mere salbutamol showed a significant increase in cardiac marker enzymes and lipid profile and decrease in antioxidant enzymes as compared to normal control indicating cardiotoxicity and myocardial cell necrosis. However, pre- and postadministration of plant mixture appreciably restored the levels of all biomarkers. Histopathological examination confirmed that the said combination was safer cardioprotective product.

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Section: Methodsmentioning

confidence: 99%

“…Gemmomodified extract of this plant (T.A (g)) is a rich source of bioactive substances. Gemmo preparations (freshly growing parts) of medicinal plants are important as these contain many active substances that start to disappear as plant reaches maturity [ 17 ].…”

Section: Introductionmentioning

confidence: 99%