Comparative Anticancer Potential of Biologically and Chemically Synthesized Gold Nanoparticles

The Breast Cancer Stem Cells Traits and Drug Resistance

“…Furthermore, existing nanobiology technologies should be fully utilized, through finding specific surface markers of targeting BCSCs, to locate and eliminate BCSCs accurately. Recently, biologically and chemically synthesized gold nanoparticles (AuNPs) (Virmani et al, 2019), silver nanoparticles (AgNPs) (Muthupandian et al, 2019) and selenium nanoparticles (SeNPs) (Vahidi et al, 2020) have attracted significant attention for their anticancer effects against cancers such as lung cancer, colorectal Cancer (Barabadi et al, 2020a), cervical cancer (Barabadi et al, 2020b) and prostate cancer (Barabadi et al, 2019a). Fortunately, AuNPs (Barabadi et al, 2019b) and AgNPs (Saravanan et al, 2020) have also been reported to play an important role in the treatment of BC.…”

Eco-Friendly Formulation of Selenium Nanoparticles and Its Functional Characterization against Breast Cancer and Normal Cells

“…In the present study, we investigated that the induction of apoptosis could be the possible mechanism of anti-proliferative activity of biosynthesized SeNPs. SeNPs used varying concentrations (5,10,15,20,25,30,35,40,45, and 50 lg/mL) to treat MDA-MB-231 cells at 48 h. Fifty percentage of cell death, which determines the inhibitory concentration (IC 50 ) value of biosynthesized SeNPs against MDA-MB-231 cells was found to be 34 lg/mL in 48 h. However, the cytotoxicity assay of biosynthesized SeNPs against HBL-100 did not exhibit significant cytotoxicity at lower concentration and cytotoxicity increases with concentration increasing above 50 lg/mL in 48 h. Our results also provide conclusive evidence for the cytotoxic effect of biosynthesized SeNPs against breast cancer MDA-MB-231 cell line compared with HBL-100 normal breast cell line [36][37][38]. Most research focuses on the toxicity of NPs consisting of chemical or physical synthesized metal oxide NPs.…”

“…Electrostatic charge, surface chemistry and photothermal activity of the metal nanoparticles potentiate therapeutic effectiveness toward cancerous cells regardless of their high drug payload [8,9]. Conventional physical and chemical approaches for the preparing of metallic nanoparticles have many issues and challenges, such as the application of organic toxic substances, by-products of reduction agents, multiple phase processes and a substantial intensity of protective agents needed for the colloidal stabilization of NPs, which can poses significant environmental and biological concerns [10].…”

<p>Comparative Assessment of Antioxidant, Anti-Diabetic and Cytotoxic Effects of Three Peel/Shell Food Waste Extract-Mediated Silver Nanoparticles</p>

“…These above disadvantages are directed towards the development of the synthesis of ecofriendly and green nanoparticles with less energy consuming by biological resources like plants, plant-derived products, microorganisms, and algae, etc. 33 Due to the lack of toxic substances, the green synthesis process is highly reliable, whereas the chemical approaches usage chemicals, which are toxic to humans. 7 In the earlier report, there is a report of no toxic effect of biosynthesized Ag nanoparticles.…”