Comparative antibody response to salmonella antigens in genetically resistant and susceptible mice

Xu, Hong-Ru; Tan, Yong; Hsu, H. S.; Moncure, Charles W.; Wang, X M

doi:10.1111/j.1365-2249.1993.tb03357.x

Cited by 5 publications

(1 citation statement)

References 13 publications

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“…MVs and SMVs, owing to their derivation from the microbial surface, naturally contain antigens important for the generation of an immune response to bacterial and fungal infection, such as immunogenic surface proteins, LPS, and capsular polysaccharide (1,4,11,70,79,85,99). This is supported by proteomic analysis of MV content, which has identified the presence of known B and/or T cell antigens (Fig.…”

Section: Functional Significance Of Membrane Vesiclesmentioning

confidence: 87%

Membrane Vesicle Release in Bacteria, Eukaryotes, and Archaea: a Conserved yet Underappreciated Aspect of Microbial Life

2012

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ABSTRACTInteraction of microbes with their environment depends on features of the dynamic microbial surface throughout cell growth and division. Surface modifications, whether used to acquire nutrients, defend against other microbes, or resist the pressures of a host immune system, facilitate adaptation to unique surroundings. The release of bioactive membrane vesicles (MVs) from the cell surface is conserved across microbial life, in bacteria, archaea, fungi, and parasites. MV production occurs not onlyin vitrobut alsoin vivoduring infection, underscoring the influence of these surface organelles in microbial physiology and pathogenesis through delivery of enzymes, toxins, communication signals, and antigens recognized by the innate and adaptive immune systems. Derived from a variety of organisms that span kingdoms of life and called by several names (membrane vesicles, outer membrane vesicles [OMVs], exosomes, shedding microvesicles, etc.), the conserved functions and mechanistic strategies of MV release are similar, including the use of ESCRT proteins and ESCRT protein homologues to facilitate these processes in archaea and eukaryotic microbes. Although forms of MV release by different organisms share similar visual, mechanistic, and functional features, there has been little comparison across microbial life. This underappreciated conservation of vesicle release, and the resulting functional impact throughout the tree of life, explored in this review, stresses the importance of vesicle-mediated processes throughout biology.

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Section: Functional Significance Of Membrane Vesiclesmentioning

confidence: 87%

Membrane Vesicle Release in Bacteria, Eukaryotes, and Archaea: a Conserved yet Underappreciated Aspect of Microbial Life

2012

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Mouse susceptibility to infection by theSalmonella abortusovisvaccine strain Rv6 is controlled by theIty/Nramp 1gene and influences the antibody but not the complement responses

Gautier¹,

Lantier²,

Lantier³

1998

Microbial Pathogenesis

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Comparative histopathology in mouse typhoid among genetically diverse mice

Moncure

Guo²,

Xu³

et al. 1998

Int J Experimental Path

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Genetically resistant CBA and A/J mice and susceptible BALB/c and C57BL/6 mice were challenged with either an identical infective dose or a minimal lethal dose of Salmonella typhimurium. The histopathological progression of the disease was examined in tissue sections prepared by the JB-4 Plus resin embedding method and compared between the resistant and susceptible mice. In a fatal disease, the lesions in both animal hosts began with focal abscesses within the first three days post infection. Mononuclear cell infiltration started by day 4 and transformed the lesions into granulomata. Well-formed granulomata were evident by day 7 and persisted in sublethally infected resistant mice. Massive bacterial proliferation and extensive tissue degeneration marked the terminal stage of a lethal challenge. There were no distinguishable features that would identify the tissue response to infection in a resistant host from a susceptible one, except that the lesions in the sublethally infected resistant mice advanced slower and were discrete and self-limiting.

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Comparative antibody response to salmonella antigens in genetically resistant and susceptible mice

Cited by 5 publications

References 13 publications

Membrane Vesicle Release in Bacteria, Eukaryotes, and Archaea: a Conserved yet Underappreciated Aspect of Microbial Life

Membrane Vesicle Release in Bacteria, Eukaryotes, and Archaea: a Conserved yet Underappreciated Aspect of Microbial Life

Mouse susceptibility to infection by theSalmonella abortusovisvaccine strain Rv6 is controlled by theIty/Nramp 1gene and influences the antibody but not the complement responses

Comparative histopathology in mouse typhoid among genetically diverse mice

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