2021
DOI: 10.1177/1559325820982163
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Comparative and Combined In Vitro Vasotoxicity of Nanoparticles Containing Lead and Cadmium

Abstract: In vitro toxicological experiments were performed on an endothelial cell line exposed to different doses of spherical nanoparticles of cadmium and/or of lead sulfides with mean diameter 37 ± 5 nm and 24 ± 4 nm, respectively. Toxic effects were estimated by Luminescent Cell Viability Assay, endothelin-1 concentration and cell size determination. Some dose-response relationships were typically monotonic (well approximated with hyperbolic function) while others were bi- or even 3-phasic and could be described wit… Show more

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Cited by 2 publications
(4 citation statements)
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“…The problem becomes even more complex where the dependence is nonmonotonic. 1,3 Monotonic dose-response relationships are often described with the Hill function (1), proportional to the cumulative function of the log-logistic distribution [4][5][6]…”
Section: Mathematical Description Of the Experimental Resultsmentioning
confidence: 99%
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“…The problem becomes even more complex where the dependence is nonmonotonic. 1,3 Monotonic dose-response relationships are often described with the Hill function (1), proportional to the cumulative function of the log-logistic distribution [4][5][6]…”
Section: Mathematical Description Of the Experimental Resultsmentioning
confidence: 99%
“…It is still more difficult to find a suitable mathematical model for a nonmonotonic dose-response relationship. Although there are lots of functional expressions for describing relationships of this type, 1,3,8 none of them is universal, being confined to a certain limited area of research only.…”
Section: Mathematical Description Of the Experimental Resultsmentioning
confidence: 99%
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