Comparative and Combined <i>In Vitro</i> Vasotoxicity of Nanoparticles Containing Lead and Cadmium

Бушуева, Т. В.; Minigalieva, Ilzira A.; Panov, Vladimir G.; Sutunkova, Marina P.; Gurvich, Vladimir B.; Shur, V. Ya.; Шишкина, Е. В.; Naumova, Anna; Artemenko, Elizaveta P.; Katsnelson, Boris A.

doi:10.1177/1559325820982163

Cited by 2 publications

(4 citation statements)

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“…The problem becomes even more complex where the dependence is nonmonotonic. 1,3 Monotonic dose-response relationships are often described with the Hill function (1), proportional to the cumulative function of the log-logistic distribution [4][5][6]…”

Section: Mathematical Description Of the Experimental Resultsmentioning

confidence: 99%

“…It is still more difficult to find a suitable mathematical model for a nonmonotonic dose-response relationship. Although there are lots of functional expressions for describing relationships of this type, 1,3,8 none of them is universal, being confined to a certain limited area of research only.…”

Section: Mathematical Description Of the Experimental Resultsmentioning

confidence: 99%

“…1,2,9,10 The objective of approximating such multiphase relationships of a hormesis-associated type becomes a difficult challenge which requires using more complex power 1,2 or special functions. 3 Like in the previous studies (for instance 1,3,11 and many others), the type of combined cytotoxicity was estimated in a model based on the Response Surface Methodology (for example 12,13 ). In this methodology, equation (3) describing the response surface Y = Y (x 1 , x 2 ) can be constructed by fitting its coefficients to experimental data…”

Section: Mathematical Description Of the Experimental Resultsmentioning

confidence: 99%

“…In the relationship of the second type, the direction of the effect changes at least twice with growth in impact, and it may be termed as hormesis in its broader sense considered in detail in. 2,3 In these publications of ours, one can find a sufficiently comprehensive review the relevant scientific literature dealing with the hormesis paradigm.…”

Section: Introductionmentioning

confidence: 99%

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New Data on Variously Directed Dose-Response Relationships and the Combined Action Types for Different Outcomes of in Vitro Nanoparticle Cytotoxicity

et al. 2021

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Spherical selenium-oxide and copper-oxide nanoparticles (SeO-NP with mean diameter 51 ± 14 nm and CuO-NP with mean diameter 21 ± 4 nm) were found to be cytotoxic for human fibroblast-like cells in vitro, as judged by decreased ATP-dependent luminescence. Compared with SeO-NP, CuO-NP produced a somewhat stronger effect of this kind. Along with cell hypertrophy developing in response to certain doses of SeO-NP and CuO-NP, our experiment also revealed doses causing a decrease in cell and cell-nucleus sizes. We observed both monotonic and different variants of nonmonotonic dose-response relationship. For the latter, we have succeeded in constructing adequate mathematical expressions based on the generalized hormesis paradigm that we had considered previously in respect of CdS-NP and PbS-NP cytotoxicity for cardiomyocites. It was demonstrated as well that combined toxicity of SeO-NP and CuO-NP is of different types depending on the outcome.

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Section: Mathematical Description Of the Experimental Resultsmentioning

confidence: 99%

Section: Mathematical Description Of the Experimental Resultsmentioning

confidence: 99%

Section: Mathematical Description Of the Experimental Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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New Data on Variously Directed Dose-Response Relationships and the Combined Action Types for Different Outcomes of in Vitro Nanoparticle Cytotoxicity

et al. 2021

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The various dose-dependent effect of selenium oxide and copper oxide nanoparticles in vitro and application of the hormesis paradigm

Panov

Minigalieva

Bushueva

et al. 2021

Hygiene and Sanitation

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Introduction. In vitro studies on a culture of cardiomyocytes have shown that dose-response relationships could be monotonic for some effects and non-monotonic for others. In this work, we wanted to demonstrate that these features of the dose-response relationship are a general pattern. Materials and methods. In vitro experiments were conducted on the culture of human fibroblast-like cells FLECH-104. The cytotoxicity of spherical nanoparticles of selenium oxide (SeO-NP) and copper oxide (CuO-NP) was studied with an average diameter of 51 ± 14 nm and 21 ± 4 nm, respectively. Results. SeO-NP and CuO-NP were cytotoxic for human fibroblast-like cells, as judged by a decrease in ATP-dependent luminescence. In this case, the cytotoxicity of CuO-NP was somewhat more substantial than the SeO-NP one. Our experiment revealed doses that cause both cell hypertrophy and a decrease in the size of cells and nuclei. Discussion. We observed both monotonic and different variants of the non-monotonic dose-response relationship. For the latter, it was possible to construct adequate mathematical expressions based on the generalized hormesis paradigm that we had considered earlier concerning the CdS-NP and PbS-NP cytotoxicity for cardiomyocytes. Conclusion. The general rule is the variability of the dose-response dependence types manifested in different cytotoxic effects of nanoparticles.

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Comparative and Combined In Vitro Vasotoxicity of Nanoparticles Containing Lead and Cadmium

Cited by 2 publications

References 24 publications

New Data on Variously Directed Dose-Response Relationships and the Combined Action Types for Different Outcomes of in Vitro Nanoparticle Cytotoxicity

New Data on Variously Directed Dose-Response Relationships and the Combined Action Types for Different Outcomes of in Vitro Nanoparticle Cytotoxicity

The various dose-dependent effect of selenium oxide and copper oxide nanoparticles in vitro and application of the hormesis paradigm

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