Comparative anatomy and angiography of the cardiac coronary venous system in four species: human, ovine, porcine, and canine

Genain, Marie‐Aude; Morlet, A.; Herrtage, M. E.; Mureşian, Horia; Anselme, F.; Latrémouille, Christian; Laborde, F; Behr, L.; Borenstein, Nicolas

doi:10.1016/j.jvc.2017.10.004

Cited by 16 publications

(18 citation statements)

References 45 publications

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“…As highlighted in Fig 11, the ablation sites correlated with the fluoroscopic and ICE imaging, placing the location of the His bundle at the mid septum, anterior to the coronary sinus. Further, the coronary sinus was confirmed to be large, the RV being smaller in comparison to the whole heart and the orientation varying when compared with humans [10,16]. Concurrently, the location of the lead attachment site was confirmed to be at the RV apex.…”

Section: Discussionmentioning

confidence: 99%

Development of a sheep model of atrioventricular block for the application of novel therapies

Farraha

Trivic

et al. 2020

PLoS ONE

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Section: Discussionmentioning

confidence: 99%

Development of a sheep model of atrioventricular block for the application of novel therapies

Farraha

Trivic

et al. 2020

PLoS ONE

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“…Further, it is well known that a large amount of significant anatomical, physiological, and phylogenetic differences exist between human and porcine hearts (Crick et al, ). There are differences not only in the general macroscopic organization, but also in the architecture of their cardiac venous systems (Genain et al, ). The question thus arises whether differences also exist in the organization and structure of the microcirculatory bed of the heart between the two species.…”

Section: Discussionmentioning

confidence: 99%

Valves of the small coronary veins in porcine hearts

Musil

Šach

Patzelt

et al. 2019

Journal of Morphology

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The aim of the study was to investigate the existence of valves in small peripheral coronary veins of porcine hearts. The study was performed on 20 porcine hearts using standard histological methods. The veins in the subepicardial and intramyocardial regions of the anterior and posterior parts of the interventricular septum and in the wall of the right atrium were studied.Valves were present in intramyocardial veins (diameter of 75-180 μm), in the veins located just beneath the external surface of the myocardium (diameter 120-170 μm) and in the terminal segments of the ventricular veins (diameter 250 μm) opening into the stems of the anterior interventricular vein and middle cardiac vein. Valves were also recorded in most veins of the subepicardial space. The described rich presence of valves in the small coronary veins may contribute to a better comprehension of their hemodynamic properties. These findings may also help to improve the understanding of the efficacy of retrograde application of medications, a novel technique in cardiology and cardiac surgery. K E Y W O R D S porcine heart, small coronary veins, valves, histological analysis

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“…Porcine and human coronary venous anatomy, while similar, have some subtle variations, which might impede translation of the current study to the human clinical experience. Genain et al reported that porcine hearts possess a greater number of afferent veins draining into the larger coronary veins and higher abundance of coronary venous valves relative to human hearts . Additionally, in pigs, the left azygous vein drains directly into the CS, but in humans, the oblique vein forms an anastomosis with the CS.…”

Section: Discussionmentioning

confidence: 99%

Catheter‐based retrograde coronary sinus infusion is a practical delivery technique for introducing biological molecules into the cardiac system

Rodenberg

Patel

Shirley

et al. 2019

Cathet Cardio Intervent

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Objectives To demonstrate coronary sinus (CS) retrograde catheterization as a practicable technique for delivering biologics into the heart. Background There are many options to deliver biologics into the heart. However, there is no single optimal technique when considering safety, biologic retention, and reproducibility. Retrograde delivery has the potential to address many of these concerns. This study evaluated retrograde CS infusion of luciferase‐expressing plasmid in a porcine model using the Advance® CS Coronary Sinus Infusion Catheter and bioluminescence imaging to track the expression of the infused biological markers. Methods Plasmid was delivered retrograde into the CS in one of three infusion volumes. Twenty‐four hours post‐infusion, hearts were excised and underwent bioluminescence imaging to characterize the expression of the infusates. Heart and lung biopsies were also assessed for luciferase expression using RT‐qPCR. Results Retrograde infusion was safe and successful in all nine test subjects. Luciferase detection was inconsistent in the low volume group. Bioluminescence was confined predominantly along the posterolateral left ventricle for medium volume infusions and was more broadly dispersed along the anterior side of the heart for high volume infusions. Tissue mRNA analysis corroborated the bioluminescence results, with the highest concentration of luciferase expression localized in the left ventricle. Conclusions Retrograde CS infusion is a promising technique for delivering biological molecules to the heart. Specifically, this study demonstrated that the low pressure coronary venous system accommodates a wide range of infusion volumes and that biological infusates can be maintained in situ following the resumption of coronary venous flow.

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Comparative anatomy and angiography of the cardiac coronary venous system in four species: human, ovine, porcine, and canine

Abstract: Anatomical differences must be considered when planning biomedical and veterinary studies incorporating cardiac veins. This study provides baseline data regarding structure and organization of the cardiac venous system.

Cited by 16 publications

References 45 publications

Development of a sheep model of atrioventricular block for the application of novel therapies

Development of a sheep model of atrioventricular block for the application of novel therapies

Valves of the small coronary veins in porcine hearts

Catheter‐based retrograde coronary sinus infusion is a practical delivery technique for introducing biological molecules into the cardiac system

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