The leaves of Amaranthus spinosusis considered to have properties to treat menstrual disorder, gastroenteritis, gall bladder inflammation, abscesses, arthritis and also snakebiteThe phytochemical analysis confirmed the presence of alkaloid, carbohydrate, glycoside, saponin, phenolic compounds, phytosterol, proteins, amino acids, flavonoids and tannins by conventional biochemical methods. The Gas Chromatography-Mass Spectrometry analysis of the ethanolic leaf extracts of Amaranthus spinosus established the existence of compoundssuch as 4- Piperidinone, 2,2,6,6-Tetramethyl (RT 19.573), Methyprylon (RT 19.583), 2 Hexanol, 2- Methyl (RT 10.629). FT-IR analysis revealed the presence of various functional compounds such as alcohol, phenol alkanes, aromatic rings and aliphatic compounds. This study assures that the ethanolic leaf extracts of Amaranthus spinosus has many biologically active compounds apart from already reported phytochemicals which could be exploited for the development of plant-based drug.