Comparative Analysis of Systolic and Isolated Diastolic Dysfunction Sado Heart Failure Study

Abstract

SUMMARYDetermining the type of cardiac dysfunction is important for implementing therapeutic strategies and for prognostic insights. We characterized systolic dysfunction (SD) and isolated diastolic dysfunction (IDD) in adults referred for echocardiographic evaluation, and compared their clinical and other characteristics. In the present work, we studied 218 patients (137 males) with cardiac dysfunction (mean age, 66.3 ± 8.3 years). SD was defined as a left ventricular ejection fraction (LVEF) of < 45%, whereas IDD was defined as a LVEF ≥ 45% in addition to the standard Doppler-echocardiography diagnostic criteria for IDD. Approximately 68% of subjects had SD (70% males). The proportions of hypertension, diabetes, and dyslipidemia were 44%, 26%, and 22%, respectively, without significant association with the type of dysfunction. Myocardial infarction (MI) was found in 31% of patients, and was significantly (P < 0.001) more prevalent among SD compared with IDD cases. Cerebral stroke (18%) and malignancy (16%) were significantly associated with IDD (29% versus 13% for SD in the case of stroke, and 26% versus 11% for SD in the case of malignancy; P = 0.008 for each). In multivariately-adjusted logistic regression analysis, the following variables were found to be significantly (P < 0.05) and independently associated with IDD: female gender (odds ratio 769-4.808]) was independently associated with SD. In conclusion, some factors/comorbidities were more likely to associate with IDD (female gender, stroke, and malignancy) or SD (previous MI) when IDD and SD were compared with each other. (Int Heart J 2008; 49: 459-469) [

Clinical characteristics and long-term clinical outcomes of Japanese heart failure patients with preserved versus reduced left ventricular ejection fraction: A prospective cohort of Shinken Database 2004–2011

“…Patients with HFpEF are older, more often female, and more frequently have hypertension compared to patients with HFrEF [2,11,12,[16][17][18][19][20][21]. Similar background differences were demonstrated in Japanese HF patients in both inpatient-based and community-based cohorts [3,4]. The differences in patients' backgrounds in our study were almost identical to those of previous reports, and patients with HFpEF were older and more often female.…”

“…The epidemiology of HF in Japan is different from that in Western countries with respect to ethnic background and etiology. However, there are few Japanese hospital-based reports about preserved left ventricular ejection fraction (LVEF) [2][3][4], and the prevalence and prognosis of HF with preserved LVEF are not well known. Tsuchihashi-Makaya et al examined patients from the Japanese Cardiac Registry of Heart Failure in Cardiology who were hospitalized for HF and demonstrated that patients with HFpEF had similar mortality rates and equally high rates of rehospitalization as those with HFrEF [4].…”

Heart failure with preserved versus reduced left ventricular systolic function: A prospective cohort of Shinken Database 2004–2005

“…The rate of diabetes and atrial fibrillation are thought to be similar between preserved and reduced LVEF. According to recent reports from Japan, similar background differences could be applied to Japanese HF patients in both inpatient-based and community-based cohorts [18,19]. Actually, the differences in patient's backgrounds in our study were almost identical to those of previous reports, in that patients with preserved LVEF tended to be older and were more likely to be women.…”

“…The epidemiology of HF in Japan should be quite different from that in Western countries in respect of ethnic background and etiology. However, there are few Japanese hospital-based reports about preserved LVEF [8,18,19], and the prevalence and prognosis of HF with preserved LVEF are not well known. The purpose of the present study was to determine the prevalence, prognosis, and predictors for mortality of HF patients in both inpatients and outpatients, with preserved versus reduced LVEF in a prospective cohort fashion.…”

O polimorfismo AGT*M235T na disfunção cardíaca de etiologia isquêmica aguda: projeto gisca

“…• Cardiac dysfunction (CD) -clinical manifestations of heart failure (Killip classes II to IV) and/or laboratory tests showing the presence of left ventricular systolic dysfunction (LVSD) during hospitalization 21,22 : echocardiography within the first 72 hours of hospital admission showing moderate or severe global systolic dysfunction associated with ejection fraction ≤ 40% using the Teichholz method 23 , or ejection fraction ≤ 40% using the Simpson method, or invasive contrast ventriculography during coronary angiography showing moderate or severe systolic dysfunction 24 .…”