Comparative Analysis of Survival Outcomes and Prognostic Factors of Supratentorial versus Cerebellar Glioblastoma in the Elderly: Does Location Really Matter?

Chandra, Ankush; Lopez‐Rivera, Victor; Dono, Antonio; Brandel, Michael G.; Lewis, Cole T.; O’Connor, Kyle P.; Sheth, Sunil A; Ballester, Leomar Y.; Aghi, Manish K.; Esquenazi, Yoshua

doi:10.1016/j.wneu.2020.11.003

Cited by 10 publications

(6 citation statements)

References 40 publications

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“…Xingwang Zhou et al demonstrated that oligodendroglioma, anaplastic glioma and glioblastoma were risk factors for early mortality in children and pointed out that glioblastoma increases early childhood mortality 16 . Ankush Chandra et al found a very meaningful study: tumours > 40 mm were associated with decreased survival for patients with supratentorial glioblastoma 17 . However, in our study, the prognosis of cerebellar glioma had little to do with the size of the tumour.…”

Section: Discussionmentioning

confidence: 98%

Nomograms for predicting the overall survival of patients with cerebellar glioma: an analysis of the surveillance epidemiology and end results (SEER) database

Li¹,

Huang²,

Chen³

et al. 2021

Sci Rep

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At present, our understanding of cerebellar glioma is still insufficient. This study collected information on patients in the SEER database to identify the predictive factors for patients with cerebellar glioma. Data from patients with cerebellar glioma diagnosed from 1975 to 2018 were retrieved from the Surveillance Epidemiology and End Results Database. We randomly divided the patients into a training group and a validation group, established a nomogram based on the training group, and used the validation group data to verify the clinical value of the model. A total of 508 patients were included in this study. Multivariate analysis was performed based on the data before randomization, and the results showed that the patient's age, WHO grade, histological type, and extent were significantly correlated with the survival rate. The C-index of the OS nomograms of the training cohort was 0.909 (95% CI, (0.880–0.938)) and 0.932 (95% CI, (0.889–0.975)) in the validation group. The calibration curve of OS for 3 and 5 years showed that there was good consistency between the actual survival probability and the predicted survival probability. For patients with cerebellar glioma, the age at diagnosis, WHO grade of the glioma, histological type, and extension are the four factors that most strongly affect the overall survival outcomes. Furthermore, our model may be a useful tool for predicting OS in these patients.

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Section: Discussionmentioning

confidence: 98%

Nomograms for predicting the overall survival of patients with cerebellar glioma: an analysis of the surveillance epidemiology and end results (SEER) database

Li¹,

Huang²,

Chen³

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Tumor location, EOR and postoperative neurological status significantly affected survival ( 26 ). The analysis of 18 registries in the Surveillance, Epidemiology and End Results (SEER) program revealed that elderly patients with cerebellar glioblastoma and supratentorial glioblastoma have similar outcomes in OS, and those undergoing maximal resection with adjuvant therapies, independent of tumor location, show improved outcomes ( 25 ).…”

Section: Surgical Resectionmentioning

confidence: 99%

Optimal managements of elderly patients with glioblastoma

Arakawa

Mineharu

Uto

et al. 2022

Japanese Journal of Clinical Oncology

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Optimizing the management of elderly patients with glioblastoma is an ongoing task in neuro-oncology. The number of patients with this tumor type is gradually increasing with the aging of the population. Although available data and practice recommendations remain limited, the current strategy is maximal safe surgical resection followed by radiotherapy in combination with temozolomide. However, survival is significantly worse than that in the younger population. Surgical resection provides survival benefit in patients with good performance status. Hypofractionated radiotherapy decreases toxicities while maintaining therapeutic efficacy, thus improving treatment adherence and subsequently leading to better quality of life. The intensity of these treatments should be balanced with patient-specific factors and consideration of quality of life. This review discusses the current optimal management in terms of efficacy and safety, as well as future perspectives.

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“…Xingwang Zhou et al demonstrates that oligodendroglioma, anaplastic glioma and glioblastoma were risk factors of early mortality for children, and pointed out that glioblastoma increases early childhood mortality 16 . Ankush Chandra et al found a very meaningful study: tumor >40 mm were associated with decreased survival for patients with supratentorial glioblastoma 17 . But in our study, the prognosis of cerebellar glioma has little to do with the size of the tumor.…”

Section: Discussionmentioning

confidence: 98%

Nomograms for predicting the overall survival of patients with cerebellar glioma: An analysis of the SEER (Surveillance Epidemiology and End Results) database

Li¹,

Huang²,

Chen³

et al. 2021

Preprint

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Purpose: At present, our understanding of cerebellar glioma is still not enough. This study collected information on patients in the seer database to determine the predictive factors patients with cerebellar glioma. Patients and Methods: The data of patients with cerebellar glioma diagnosed from 1975 to 2018 were retrieved from the Surveillance Epidemiology and End Results Database. We randomly divide the data into a training group and a validation group, establish a nomogram based on the training group, and use the validation group data to verify the clinical value of the model. Results: A total of 508 patients were included in this study. Multivariate analysis was performed based on the data before randomization, and the results showed that the patient's age, the tumor's WHO grade, histological type, and extension are significantly correlated with the survival rate. The c index of OS nomograms of the training cohort was 0.909 (95% CI,(0.880-0.938）) and 0.932(95% CI, (0.889-0.975)) in validation group. The calibration curve of OS for 3 and 5 years show that there was a good consistency between the actual survival probability and the predicted survival probability.Conclusion: For patients with cerebellar glioma, the age of the patient at the time of diagnosis, WHO grade of the glioma, histological type, and extension are the four most prominent factors that affect the overall survival outcomes. Furthermore, our model may be a useful tool for predicting OS in these patients.

show abstract

Comparative Analysis of Survival Outcomes and Prognostic Factors of Supratentorial versus Cerebellar Glioblastoma in the Elderly: Does Location Really Matter?

Cited by 10 publications

References 40 publications

Nomograms for predicting the overall survival of patients with cerebellar glioma: an analysis of the surveillance epidemiology and end results (SEER) database

Nomograms for predicting the overall survival of patients with cerebellar glioma: an analysis of the surveillance epidemiology and end results (SEER) database

Optimal managements of elderly patients with glioblastoma

Nomograms for predicting the overall survival of patients with cerebellar glioma: An analysis of the SEER (Surveillance Epidemiology and End Results) database

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