Comparative analysis of salivary sialic acid levels in patients with chronic obstructive pulmonary disease and chronic periodontitis patients: A biochemical study

Rathod, Surekha; Shori, Tony; Sarda, Trupti; Raj, Anubha; Jadhav, Padmaja

doi:10.4103/ijdr.ijdr_106_16

Cited by 8 publications

(7 citation statements)

References 1 publication

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“…The clinical observation and experimental models described an enhanced level of total serum sialic acid and sialoglycans on the human vein endothelial cells as a marker of pathology and significant risk factor of coronary artery disease (CAD) and angiopathy [ 91 , 92 ]. Moreover, the glycome analysis in asthma and COPD showed that the alterations in sialoglycans correspond to the progress of disease [ 93 , 94 , 95 ]. According to Guo, the lung pathology inducing factors, e.g., tobacco, can be considered as the crucial players in the promotion of SARS-CoV-2 infection and associated with the risk of severe COVID-19 [ 95 ].…”

Section: Sialic Acids In Covs Infectionsmentioning

confidence: 99%

Coronaviruses: Is Sialic Acid a Gate to the Eye of Cytokine Storm? From the Entry to the Effects

Wielgat

Rogowski

Godlewska

et al. 2020

Cells

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Coronaviruses (CoVs) are a diverse family of the enveloped human and animal viruses reported as causative agents for respiratory and intestinal infections. The high pathogenic potential of human CoVs, including SARS-CoV, MERS-CoV and SARS-CoV-2, is closely related to the invasion mechanisms underlying the attachment and entry of viral particles to the host cells. There is increasing evidence that sialylated compounds of cellular glycocalyx can serve as an important factor in the mechanism of CoVs infection. Additionally, the sialic acid-mediated cross-reactivity with the host immune lectins is known to exert the immune response of different intensity in selected pathological stages. Here, we focus on the last findings in the field of glycobiology in the context of the role of sialic acid in tissue tropism, viral entry kinetics and immune regulation in the CoVs infections.

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Section: Sialic Acids In Covs Infectionsmentioning

confidence: 99%

Coronaviruses: Is Sialic Acid a Gate to the Eye of Cytokine Storm? From the Entry to the Effects

Wielgat

Rogowski

Godlewska

et al. 2020

Cells

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“…Periodontitis is a chronic infectious disease caused by infectious bacteria and host response and associates with many other systematic diseases. [1][2][3] Periodontitis can lead to destruction of tooth supported tissues, which makes it the main cause of tooth loss of adults. 4,5 Conventional treatments including debridement of the tooth root surface, guided tissue regeneration (GTR) and bone graft placement failed to reach satisfactory curative effect.…”

Section: Introductionmentioning

confidence: 99%

“…Periodontitis is a chronic infectious disease caused by infectious bacteria and host response and associates with many other systematic diseases 1,2,3. Periodontitis can lead to destruction of tooth supported tissues, which makes it the main cause of tooth loss of adults 4,5.…”

Section: Introductionmentioning

confidence: 99%

SFRP2 promotes stem cells from apical papilla‐mediated periodontal tissue regeneration in miniature pig

Han

Yang

et al. 2019

J of Oral Rehabilitation

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Mesenchymal stem cell-based therapy is a reliable treatment for periodontal tissue regeneration, while ideal regeneration rate is still a facing problem. In previous study, we found SFRP2 a promising gene in modulating mesenchymal stem cells potential. We further investigated its role on periodontal tissue regeneration. We created periodontitis model in miniature pigs and locally injected with stem cells from apical papilla (SCAP). The periodontitis models were classed into three groups, SFRP2-SCAP group (injected with SCAP overexpressing with SFRP2), SCAP group (injected with SCAP transduced with vector backbone) and saline group (vehicle group injected with saline). Clinical assignment, CT scanning, histopathological assessment and quantitative analysis were applied to evaluate the regeneration effect. Twelve weeks after the injection, we found healthier gingival status in SFRP2-SCAP group than the other two groups. Clinical assignment results showed values of probing depth, gingival recession and attachment loss were improved in SFRP2-SCAP group than that of SCAP group and saline group. The volume of newborn bone was also enhanced in SFRP2-SCAP group than SCAP group and saline group. The difference of clinical assignments and newborn bone between each group was significant relevant. HE staining demonstrated increased tissue regeneration in SFRP2-SCAP group than SCAP group and saline group. Our findings revealed that SFRP2 could enhance SCAP-mediated periodontal tissue regeneration and provide a potential target for improving the regeneration of periodontal tissue.

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“…Periodontitis is a wide-spread chronic infectious disease that can destruct teeth supporting tissues, associates with many other diseases, and is the main cause of tooth loss of adults [ 1 – 5 ]. While the effects of restoring hard and soft periodontal tissues by conventional treatments remain unsatisfactory [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Local Injection of Allogeneic Stem Cells from Apical Papilla Enhanced Periodontal Tissue Regeneration in Minipig Model of Periodontitis

Han

Zhang

et al. 2018

BioMed Research International

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Background Discovering suitable seeding cells and simple application technique will be beneficial for MSC-mediated treatment of periodontitis. Stem cells from apical papilla (SCAPs) might be the candidate seeding cell for the periodontal tissues regeneration based on their origin and characters. In this research, we investigated the effect of SCAPs on periodontal tissue regeneration in swine by local injection. Methods We established experimental periodontitis model in miniature pigs and then treated them with SCAPs by local injection. Clinical assessments, computed tomography (CT) scanning, histologic examination, and quantitative measurements were used to evaluate the effect of periodontal tissues regeneration. Results At 12 weeks after injection, clinical assessments showed that probing depth, gingival recession, and attachment loss values were 5.44±0.77 mm versus 7.33±1.0 mm (p<0.01), 2.33±0.33 mm versus 2.11±0.69 mm (p>0.05), and 7.78±0.84 mm versus 9.44±1.07 mm (p<0.01) in SCAPs group and 0.9% NaCl group, respectively. CT scan results showed a significant increase of 12.86 mm3 alveolar bone regeneration in SCAPs group compared with 0.9% NaCl group. In addition, histopathology results demonstrated remarkable regeneration in SCAPs group, whereas regeneration of periodontal tissue was hardly found in 0.9% NaCl group. Conclusion Local injection of SCAPs could effectively restore tissue defects brought about by periodontitis in the swine model. Thus, SCAPs, as an easily accessible dental-deriving stem cell, may serve as an alternative application for periodontitis treatment.

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Comparative analysis of salivary sialic acid levels in patients with chronic obstructive pulmonary disease and chronic periodontitis patients: A biochemical study

Cited by 8 publications

References 1 publication

Coronaviruses: Is Sialic Acid a Gate to the Eye of Cytokine Storm? From the Entry to the Effects

Coronaviruses: Is Sialic Acid a Gate to the Eye of Cytokine Storm? From the Entry to the Effects

SFRP2 promotes stem cells from apical papilla‐mediated periodontal tissue regeneration in miniature pig

Local Injection of Allogeneic Stem Cells from Apical Papilla Enhanced Periodontal Tissue Regeneration in Minipig Model of Periodontitis

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