Comparative analysis of RSV-related hospitalisations in children and adults over a 7 year-period before, during and after the COVID-19 pandemic

Kiefer, Alexander; Pemmerl, Sylvia; Kabesch, Michael; Ambrosch, Andreas

doi:10.1016/j.jcv.2023.105530

Cited by 7 publications

(4 citation statements)

References 24 publications

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“…In contrast, adults in the same season experienced fewer RSV cases compared to the pre-pandemic period. In 2022/2023, the number of RSV cases in adults aligned with expectations in the strong season [ 59 ]. Thus, we believe that our pre-pandemic estimates still provide meaningful insight into the current RSV burden.…”

Section: Discussionmentioning

confidence: 79%

“…The epidemiology of RSV was substantially impacted by the implementation of nonpharmaceutical interventions during the COVID-19 pandemic in 2020–2021. During that period, an unprecedented decline in RSV cases in both children and adults in Germany was observed [ 58 , 59 ]. However, in 2021/2022, there was a sudden increase and subsequent decrease in hospitalizations in children.…”

Section: Discussionmentioning

confidence: 99%

“…The DADB database has been found to be fairly representative of the German population, with similar age-gender and morbidity structure [ 57 ]. The study period of 2015–2019 was selected to avoid distortion of RSV epidemiology during pandemic of COVID-19 [ 58 , 59 ].…”

Section: Methodsmentioning

confidence: 99%

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Estimated Incidence of Hospitalizations and Deaths Attributable to Respiratory Syncytial Virus Infections Among Adults in Germany Between 2015 and 2019

Polkowska-Kramek,

Begier,

Bruyndonckx

et al. 2024

Infect Dis Ther

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Introduction Respiratory syncytial virus (RSV) burden in adults is underestimated mainly due to unspecific symptoms and limited standard-of-care testing. We estimated the population-based incidence of hospitalization and mortality attributable to RSV among adults with and without risk factors in Germany. Methods Weekly counts of hospitalizations and deaths for respiratory, cardiovascular, and cardiorespiratory diseases were obtained (Statutory Health Insurance database, 2015–2019). A quasi-Poisson regression model was fitted to estimate the number of hospitalizations and deaths attributable to RSV as a function of periodic and aperiodic time trends, and viral activity while allowing for potential overdispersion. Weekly counts of RSV and influenza hospitalizations in children < 2 years and adults ≥ 60 years, respectively, were used as viral activity indicators. Models were stratified by age group and risk status (defined as presence of selected comorbidities). Results Population-based RSV-attributable hospitalization incidence rates were high among adults ≥ 60 years: respiratory hospitalizations (236–363 per 100,000 person-years) and cardiorespiratory hospitalizations (584–912 per 100,000 person-years). RSV accounted for 2–3% of all cardiorespiratory hospitalizations in this age group. The increase in cardiorespiratory hospitalization risk associated with underlying risk factors was greater in 18–44 year old persons (five to sixfold higher) than in ≥ 75 year old persons (two to threefold higher). Conclusions This is a first model-based study to comprehensively assess adult RSV burden in Germany. Estimated cardiorespiratory RSV hospitalization rates increased with age and were substantially higher in people with risk factors compared to those without risk factors. Our study indicates that RSV, like other respiratory viruses, contributes to both respiratory and cardiovascular hospitalizations. Effective prevention strategies are needed, especially among older adults ≥ 60 years and among adults with underlying risk factors. Supplementary Information The online version contains supplementary material available at 10.1007/s40121-024-00951-0.

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

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Estimated Incidence of Hospitalizations and Deaths Attributable to Respiratory Syncytial Virus Infections Among Adults in Germany Between 2015 and 2019

Polkowska-Kramek,

Begier,

Bruyndonckx

et al. 2024

Infect Dis Ther

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“…For the current study, claims data were selected from January 1, 2014, and December 31, 2019. The study period was chosen to exclude the COVID-19 pandemic era to ensure results could be compared across the study years and to exclude irregular RSV-seasons during and after the COVID-19 pandemic (15).…”

Section: Methodsmentioning

confidence: 99%

Clinical and economic burden of lower respiratory tract infection due to respiratory syncytial virus in young children in Germany

Beese,

Bayer,

Huebbe

et al. 2024

Preprint

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Background: Clinical and economic burden of infections due to respiratory syntactical virus (RSV) in children <2 years of age in Germany is still underestimated. Methods: In a retrospective health claims analysis, we identified RSV inpatient and outpatient episodes based on year-round specific RSV ICD-10 diagnoses or unspecified lower respiratory tract infection diagnoses during the RSV-season. High-risk groups were defined by ICD-10 codes. Hospitalization costs per patient were incurred between the beginning and end of an RSV episode. All-cause costs were compared to a matched control group without RSV infections based on age, sex, and prematurity in the inpatient and outpatient sectors. Results The incidence of hospitalization due to RSV was substantially higher in infants (21/1,000) than in toddlers (5.4/1,000). Most hospitalizations occurred in the first six months of life; the highest hospitalization incidences were observed in the second month of life (46/1,000). Infants with risk factors had a 2.4 times higher risk for hospitalization than those without. The economic burden per episode was high in the first 3 months of life and especially for those with risk factors and/or prematurity. However, overall annual resource utilization for the healthcare system was higher for healthy children with no underlying risk factors than for those with risk factors. Conclusion: RSV in children <2 years of age causes a considerable burden for the German healthcare system, both clinically and economically. Newborns, premature infants, children with chronic underlying risk factors are at highest risk for severe outcomes, but the overall disease burden affects healthy infants.

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Rise in complications of acute otitis media during and after the COVID-19 pandemic

Hollborn,

Lachmann,

Strüder

et al. 2024

Eur Arch Otorhinolaryngol

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Purpose After the lifting of nonpharmaceutical interventions (NPIs) during the COVID-19 pandemic, clinical observation showed an increase in complications of acute otitis, followed by a rise in the number of mastoidectomies performed. The aim of this study was to record the number of mastoidectomies performed before, during and after the COVID-19 pandemic as an indicator for complications of acute otitis media. Methods Data were collected from a tertiary hospital in a university setting, as well as from four major public health insurance companies in Germany. The data of 24,824,763 German citizens during a period from 2014 until 2023 were analyzed. Results According to the data, during the COVID-19 pandemic, the number of mastoidectomies performed dropped by 54% for children aged 0–6 and by 62% for children aged 7–18. For adults, there were 30% fewer mastoidectomies performed between 2020 and 2022. After the lifting of most NPI’s in the season from July 2022 to June 2023, there was a sharp increase in the number of mastoidectomies performed on patients of all ages. Conclusions During the COVID-19 pandemic, a decrease in the number of mastoidectomies performed was seen, suggesting a lower incidence of complicated acute otitis, most likely linked to the general decrease of upper airway infections due to NPI’s. In contrast, a sharp increase in the incidence of complicated otitis occurred after the hygiene measures were lifted. The current development causes a more frequent performance of mastoidectomies, thus entailing a change in the challenges for everyday clinical practice.

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Comparative analysis of RSV-related hospitalisations in children and adults over a 7 year-period before, during and after the COVID-19 pandemic

Cited by 7 publications

References 24 publications

Estimated Incidence of Hospitalizations and Deaths Attributable to Respiratory Syncytial Virus Infections Among Adults in Germany Between 2015 and 2019

Estimated Incidence of Hospitalizations and Deaths Attributable to Respiratory Syncytial Virus Infections Among Adults in Germany Between 2015 and 2019

Clinical and economic burden of lower respiratory tract infection due to respiratory syncytial virus in young children in Germany

Rise in complications of acute otitis media during and after the COVID-19 pandemic

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