Comparative analysis of presence of Cytomegalovirus (CMV) and Epsteinbarr virus -1 (EBV-1) in cases of chronic periodontitis and aggressive periodontitis with controls

Abstract

Our studyshowed that the prevalence of EBV1 was higher in chronic and aggressive periodontitis subjects compared to controls and the prevalence of CMV was higher in aggressive periodontitis patients. The virus positive sites showed higher pocket depth compared to virus negative sites.

Prevalence of Herpesvirus and Correlation with Clinical Parameters in Indian Subjects with Chronic Periodontitis

“…The occurrence of herpesvirus is known to vary with different geographical locations, ethnicity, type of periodontal lesion being studied and the viral identification technique employed. 2,7 The current study found the occurrence of both the viruses similar to the previous reports by Sharma et al 9 and Dani et al, 17 however, Bilichodmath et al 10 found higher levels of EBV in chronic periodontitis patients. The findings of the present study were at lower levels as compared to some studies done in other countries.…”

“…In the current study, pocket depth was deeper in EBV positive sites as compared the negative sites, the difference was not significant. Although the findings of present study were similar to the finding of Sharma et al, 9 in this study there was no correlation between the viruses and clinical parameters when adjusted for age and gender (Univariate analysis). They did not see any CAL in healthy subjects which could depend on the different subject inclusion criteria.…”

“…7,18,19 Although few studies showed similar detection rates of HCMV as in our study, there has been a wide and varied report with high levels of viruses to none in certain population with healthy periodontium. 7,9,17,18,[20][21][22][23] In CP, there have been varied reports with some studies finding very high levels of EBV and HCMV. 10,18,20,21,23 Our results showed significantly higher levels of both the HCMV and the EBV virus in CP as compared to the healthy periodontium but still was lower than the median range as quoted by Slots 2010.…”

“…5 There has been conflicting evidence found in a few studies from around the globe which suggest that the EBV and the HCMV are present at fewer periodontal sites than considered otherwise. [6][7][8][9][10][11][12] Because of the paucity of data and studies with larger sample size in Indian subjects, the exact picture of the presence of the herpesvirus in this population is still unclear. This study was undertaken to determine…”

Prevalence of Epstein–Barr virus and cytomegalovirus in Bulgarian dental patients

“…Recent investigations suggest that the viruses of the family Herpesviridae are associated with periodontal disease (16,17,18). …”