Comparative analysis of HD2 type histone deacetylases in higher plants

Dangl, Markus; Brosch, Gerald; Haas, Hubertus; Loidl, Peter; Lusser, Alexandra

doi:10.1007/s004250000506

Cited by 83 publications

(82 citation statements)

References 27 publications

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“…Arabidopsis histone deacetylases (HDACs) have been classified into three families (Hollender and Liu, 2008;Alinsug et al, 2009). The first one contains members homologous to the yeast RPD3 (reduced potassium deficiency 3) and HDA1 proteins; the second, the HD-tuins (HDT1 through 3), appears to be plant-specific (Wu et al, 2000;Dangl et al, 2001) and the third family contains homologs of the yeast silent information regulator 2 (Sir2), a (NAD)-dependent HDAC (Pandey et al, 2002;Hollender and Liu, 2008). The main conclusion that we can extract from the data available is that a fine balance between HAT and HDAC activities is at the core of crucial processes during plant development.…”

Section: Histone Acetylases and Deacetylasesmentioning

confidence: 99%

Impact of nucleosome dynamics and histone modifications on cell proliferation during Arabidopsis development

et al. 2010

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Eukaryotic chromatin is a highly structured macromolecular complex of which DNA is wrapped around a histone-containing core. DNA can be methylated at specific C residues and each histone molecule can be covalently modified at a large variety of amino acids in both their tail and core domains. Furthermore, nucleosomes are not static entities and both their position and histone composition can also vary. As a consequence, chromatin behaves as a highly dynamic cellular component with a large combinatorial complexity beyond DNA sequence that conforms the epigenetic landscape. This has key consequences on various developmental processes such as root and flower development, gametophyte and embryo formation and response to the environment, among others. Recent evidence indicate that posttranslational modifications of histones also affect cell cycle progression and processes depending on a correct balance of proliferating cell populations, which in the context of a developing organisms includes cell cycle, stem cell dynamics and the exit from the cell cycle to endoreplication and cell differentiation. The impact of epigenetic modifications on these processes will be reviewed here.

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Section: Histone Acetylases and Deacetylasesmentioning

confidence: 99%

Impact of nucleosome dynamics and histone modifications on cell proliferation during Arabidopsis development

et al. 2010

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“…In addition, plants contain an uncommon class of HDACs, the HD2 class, which was identified in plants only (Lusser et al, 1997;Aravind and Koonin, 1998;Wu et al, 2000aWu et al, , 2003Dangl et al, 2001;Zhou et al, 2004). Studies on the mechanism of action of HDACs in plants are beginning to emerge.…”

Section: Introductionmentioning

confidence: 99%

HISTONE DEACETYLASE19 Is Involved in Jasmonic Acid and Ethylene Signaling of Pathogen Response in Arabidopsis

et al. 2005

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Histone acetylation is modulated through the action of histone acetyltransferases and deacetylases, which play key roles in the regulation of eukaryotic gene expression. Previously, we have identified a yeast histone deacetylase REDUCED POTASSIUM DEPENDENCY3 (RPD3) homolog, HISTONE DEACETYLASE19 (HDA19) (AtRPD3A), in Arabidopsis thaliana. Here, we report further study of the expression and function of HDA19. Analysis of Arabidopsis plants containing the HDA19:b-glucuronidase fusion gene revealed that HDA19 was expressed throughout the life of the plant and in most plant organs examined. In addition, the expression of HDA19 was induced by wounding, the pathogen Alternaria brassicicola, and the plant hormones jasmonic acid and ethylene. Using green fluorescent protein fusion, we demonstrated that HDA19 accumulated in the nuclei of Arabidopsis cells. Overexpression of HDA19 in 35S:HDA19 plants decreased histone acetylation levels, whereas downregulation of HDA19 in HDA19-RNA interference (RNAi) plants increased histone acetylation levels. In comparison with wild-type plants, 35S:HDA19 transgenic plants had increased expression of ETHYLENE RESPONSE FACTOR1 and were more resistant to the pathogen A. brassicicola. The expression of jasmonic acid and ethylene regulated PATHOGENESIS-RELATED genes, Basic Chitinase and b-1,3-Glucanase, was upregulated in 35S:HDA19 plants but downregulated in HDA19-RNAi plants. Our studies provide evidence that HDA19 may regulate gene expression involved in jasmonic acid and ethylene signaling of pathogen response in Arabidopsis.

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“…The members of the second family of plant HDACs, termed the SRT family, are related to yeast Sir2 (Imai et al, 2000). In contrast to other eukaryotes, plants contain a third family of enzymes, the nucleolar-phosphoproteins HD2 (HDT gene family), which appear to be plantspecific (Lusser et al, 1997;Dangl et al, 2001).…”

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Expression Profile and Cellular Localization of Maize Rpd3-Type Histone Deacetylases during Plant Development

et al. 2003

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We analyzed the expression profile and cellular localization of the maize (Zea mays) Rpd3-type histone deacetylases genes ZmRpd3/101, ZmRpd3/102, and ZmRpd3/108 (indicated as ZmHDA101, ZmHDA102, and ZmHDA108 in the Plant Chromatin Database). This study shows that maize Rpd3 transcripts are present in all the organs and cellular domains analyzed, but we found that their amounts change during development, accumulating in the inner region of the endosperm, in vascular zones of the nucellus, in the tapetum, and in the tetrads. A similar expression profile and nucleus-cytoplasmic localization was observed for ZmRpd3 proteins. Glutathione S-transferase pull-down assays show that ZmRpd3 proteins can interact with the maize retinoblastoma-related (ZmRBR1) protein, an important regulator of cell cycle progression, and with the maize retinoblastoma-associated protein (ZmRbAp1). However, the three ZmRpd3 proteins do not mutually compete in the binding. These results suggest a general role of ZmRpd3 genes in the plant cell cycle and development. These observations also provide indications on possible mechanisms regulating their transcription and protein accumulation. Similarities in the gene expression profiles and protein interactions may indicate that functional redundancy among members of the ZmRpd3 gene family exists. However, a degree of functional divergence is also supported by our findings.Plant development is a striking example of a highly orchestrated biological process. Recent advances demonstrate that this intricate process is accomplished by diverse mechanisms and networks that operate at distinct levels within the nucleus (Goodrich and Tweedie, 2002). A fundamental mechanism controlling the selectivity of gene expression is the ability of many transcription factors to access the genome of eukaryotes (Struhl, 1999). This is achieved by packaging genes into chromatin, which impedes the binding of any proteins to their target DNA sequences. The accessibility of DNA to protein interaction is regulated by different enzymatic complexes that modulate nucleosomal structure. In the past few years, it has been shown that posttranslational modifications of histones, including acetylation, methylation, phosphorylation, and ubiquitination play a key role in modulating dynamic changes in chromatin structure and gene activity (Wu and Grunstein, 2000). Distinct histone modification patterns, together with direct modifications of the DNA, such as DNA methylation, are believed to form an epigenetic code acting as epigenetic marks or docking elements specifically read by regulatory factors that, in turn, can alter chromatin structure and regulate transcription (Strahl and Allis, 2000;Schreiber and Bernstein, 2002;Turner, 2002).Histone acetylation is the best-characterized type of histone modification (Cress and Seto, 2000;Roth et al., 2001). The enzymes responsible for maintaining the steady-state balance of histone acetylation are the histone acetyltransferases (HATs) and histone deacetylases (HDACs). Both enzymes are members o...

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Comparative analysis of HD2 type histone deacetylases in higher plants

Cited by 83 publications

References 27 publications

Impact of nucleosome dynamics and histone modifications on cell proliferation during Arabidopsis development

Impact of nucleosome dynamics and histone modifications on cell proliferation during Arabidopsis development

HISTONE DEACETYLASE19 Is Involved in Jasmonic Acid and Ethylene Signaling of Pathogen Response in Arabidopsis

Expression Profile and Cellular Localization of Maize Rpd3-Type Histone Deacetylases during Plant Development

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