Comparative analysis of different geroprotective methods

Passport and biological age in the choice of metabolic geroprophylactic therapy

“…The degree of geroprophylactic effectiveness varied depending on the method of exposure and, in terms of research, on the calendar age of the subjects. The results of the effectiveness of reducing BV after treatment (compared with BV before treatment and taking into account the indices of the control groups) are located in the following sequence: combined use), H -Glu -Asp -Arg -OH and H -Lys -Glu -Asp -OH led to a decrease in BV in the group of elderly people by 12.8 years (p <0.01), and in middle age by 3.9 years, vesugen -7 years (p <0.01), regardless of age; interleukin-2 -by 7 years (p <0.001, regardless of the calendar age; dry carbon dioxide baths -by 5.5 years (p <0.001), regardless of the calendar age; hypoxytherapy -by 4.8 years (p <0.001) only in middleaged people; alternating exposure to dry carbon dioxide baths and hyperbaric oxygenation by 4.6 years (p <0.01) regardless of calendar age; hyperbaric oxygenation -by 4 years (p <0.001) and ozone therapyby 2.5 years (p <0.05) only in middle-aged people; amino acid L-arginine -by 1.3 years regardless of the passport age (p <0.05) [9,17,21] (fig. 1).…”

“…Exclusion criteria from the studied and control groups were the presence during the examination and (or) a history of less than 12 months before the study of acute or subacute conditions for any nosological forms, injuries, massive surgical interventions, the use of anesthesia, moderate and (or) severe stages of acute or chronic pathology, malignant tumors, severe functional failure. Representatives of the studied groups within 2 to 4 weeks received the following therapeutic effects in medium therapeutic dosages or regimens: hyperbaric oxygenation (HBO) sessions (BLKS-301M and OKA-MT-S "Barocenter", Moscow, Russia), daily for 40 minutes 1.3 -1.8 ATA total of 10 sessions, dry carbon dioxide baths ("REABOX -SUV "," Prima-Med ", Moscow, Russia) 40 minutes a day for 8 days [17], hypoxytherapy (breathing in a hypoxic gas mixture with 10% oxygen -GHS-10 -12 daily procedures lasting 40 minutes in a cyclically fractionated mode, alternating exposure to HBO and dry carbon dioxide baths, ozone therapy (ozonizer "Medozons", Nizhny Novgorod, Russia), 6 intravenous transfusion sessions in 20-30 minutes. ozonated for 15 minutes saline solution once every 2 days [9,17], interleukin-2 (Roncoleukin-2, Biotech LLC, St. Petersburg, Russia) intramuscularly 0.5 mg (500,000 ME) once a day every other day for 10 days (5 injections in total), H -Glu -Asp -Arg -OH (pinealon) and H -Lys -Glu -Asp -OH (vesugen) (HBO LLC, RAS, Firma Vita, g. St. Petersburg, Russia) 1 capsule (20 mg of active ingredient) 2 times a day for 20 days, L-arginine (Vazoton, Altayvitamins CJSC, Biysk, Russia) orally for 14 days, 500 mg 2 times a day.…”

“…All the geroprophylactic regimens studied by us were based on the use of means and methods of metabolic therapy, a special case of which can be considered gas therapy. Our general impressions of the metabolic therapy that we used for at least 2 decades have allowed us to highlight several of their characteristics: the principle of treatment is the exposure to the body's natural metabolites, a wide range of indications, the absence or minimum of contraindications, the use of various routes of administration to the body (inhalation, oral, parenteral), has as its primary acceptor the elements of metabolism in the cell itself (enzymes, substrates, products of chemical reactions, receptors, secondary messengers), absent or minimal side effect, as a leading result, the normalization of the leading indicators of metabolism is initially present, but, as a rule, there is a need for prolonged use of metabolic effects to achieve a stable effect [5,9,17,21]. In the light of these ideas, our results on a comparative characteristic of the effectiveness of geroprophylactic drugs indicate the priority use of the most effective in terms of BV if it is necessary to quickly achieve the effect, as a rule, if a patient has a sharply accelerated type of aging (according to BV or other criteria).…”

Use of dry carbonic acid gas baths to correct human biological age

“…Patients of both age groups in the experiment received a course of transcutaneous exposure in cutaneous resorptive method of carbon dioxide high concentrations using dry carbonic acid gas baths (DCAGB) REABOX-SUV" ("Prima-med", Moscow) according to the methodology of P.G. Tsarfis [1,4,21]. The course consisted of 10 daily sessions of 40 minutes, on the torso and limbs of a naked patient with a gas mixture of 30-40% carbon dioxide, humidity of 98%, t=30-40 C0 and pressure of 600-800 mm Hg.…”

“…The problem of organism aging is one of the most pressing issues of the modern science. Currently, there are many different theories about the causes and mechanisms of living organisms aging, indicating that there is no consensus in understanding this complex process [ 1,2,3,4]. In turn, this is the main reason for the lack of universal ways to correct biological age and slow the human aging rate.…”