Comparative analysis of cortical microinfarcts and microbleeds using 3.0-tesla postmortem magnetic resonance images and histopathology

Niwa, Atsushi; Shindo, Akihiro; Matsuo, Kimiko; Ishikawa, Hiroyuki; Tanigushi, A.; Takase, Sadao; Maeda, Masayuki; Akatsu, Yorikazu; Hashizume, Yasuo; Tomimoto, Hidekazu

doi:10.1016/j.jns.2017.08.2281

Cited by 2 publications

(16 citation statements)

References 20 publications

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Section: Resultsmentioning

confidence: 99%

“…The microinfarct studies were from four groups in different countries, including at least 202 subjects [35–40]. Four papers directly compared lesions identified on MRI with histology [37–40]. At least 19/202 subjects had microinfarcts although it was not possible to determine how many had lesions in two papers [35,36].…”

Section: Resultsmentioning

confidence: 99%

“…At least 19/202 subjects had microinfarcts although it was not possible to determine how many had lesions in two papers [35,36]. The age range was 62–98 years in the three papers where age could be calculated or was given [37,39,40].…”

Section: Resultsmentioning

confidence: 99%

“…Twelve studies collected subjects’ data retrospectively (Table 3; Figure 2) from different, often multiple, sources including medical notes [37–39,41–49], cause of death (not specifically stated where these data were obtained) [37,44,48–50], autopsy reports [38,39,44,45] and interviewing relatives [46]. Many did not report how or when subject data were collected [32,33,35,36,40,51–58]. Ten studies collected clinical information prospectively [34,59–67], and one provided no subject information [68].…”

Section: Resultsmentioning

confidence: 99%

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Correlations in post‐mortem imaging‐histopathology studies of sporadic human cerebral small vessel disease: A systematic review

Humphreys

Smith

2021

Neuropathology Appl Neurobio

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Aims Sporadic human cerebral small vessel disease (SVD) commonly causes stroke and dementia but its pathogenesis is poorly understood. There are recognised neuroimaging and histopathological features. However, relatively few studies have examined the relationship between the radiological and pathological correlates of SVD; better correlation would promote greater insight into the underlying biological changes. Methods We performed a systematic review to collate and appraise the information derived from studies that correlated histological with neuroimaging‐defined SVD lesions. We searched for studies describing post‐mortem imaging and histological tissue examination in adults, extracted data from published studies, categorised the information and compiled this narrative. Results We identified 38 relevant studies, including at least 1146 subjects, 342 of these with SVD: 29 studies focussed on neuroradiological white matter lesions (WML), six on microinfarcts and three on dilated perivascular spaces (PVS) and lacunes. The histopathology terminology was diverse with few robust definitions. Reporting and methodology varied widely between studies, precluding formal meta‐analysis. PVS and ‘oedema’ were frequent findings in WML, being described in at least 94 and 18 radiological WML, respectively, in addition to myelin pallor. Histopathological changes extended beyond the radiological lesion margins in at least 33 radiological WML. At least 43 radiological lesions not seen pathologically and at least 178 histological lesions were not identified on imaging. Conclusions Histopathological assessment of human SVD is hindered by inconsistent methodological approaches and unstandardised definitions. The data from this systematic review will help to develop standardised definitions to promote consistency in human SVD research.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Correlations in post‐mortem imaging‐histopathology studies of sporadic human cerebral small vessel disease: A systematic review

Humphreys

Smith

2021

Neuropathology Appl Neurobio

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“…They are meant to represent perivascular focal collection of hemosiderin deposits, 1 but only a few studies have explored their histological correlates. [2][3][4][5] Until now, the literature has mainly focused on the epidemiology of CMBs. Prevalence, associated factors, and natural history of CMBs have been described in both community-based samples and specific clinical settings, such as cerebral amyloid angiopathy (CAA) 6 and Alzheimer's disease (AD).…”

Section: Introductionmentioning

confidence: 99%

Cerebral microbleeds: Beyond the macroscope

Pétrault

Casolla

Ouk

et al. 2019

International Journal of Stroke

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While being increasingly recognized in clinical routine, brain microbleeds remain a puzzling finding for physicians. These small dot-like lesions are thought to be old perivascular collections of hemosiderin deposits. They can be found in different neurological settings such as cerebrovascular or neurodegenerative diseases. While their microscopic size would suggest considering these lesions as anecdotal, they are now regarded as biomarkers of severity of an underlying cerebrovascular disease. Their natural history and the interactions with surrounding brain cells remain unknown. However, their presence may impact therapeutic decisions. Deciphering the biological mechanisms leading to, or following microbleeds would enable us to address a key question: do microbleeds arise and impact the surrounding parenchyma like a miniature version of intracerebral hemorrhages or do they represent a different kind of injury? We hereby discuss, based on both clinical and experimental literature, the gap between the definition of microbleeds coming from neuroimaging and the pathophysiological hypotheses raised from histopathological and experimental data. Our analysis supports the need for a convergent effort from clinicians and basic scientists to go beyond the current “macro” view and disclose the cellular and molecular insights of these cerebral hemorrhagic microlesions.

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Comparative analysis of cortical microinfarcts and microbleeds using 3.0-tesla postmortem magnetic resonance images and histopathology

Cited by 2 publications

References 20 publications

Correlations in post‐mortem imaging‐histopathology studies of sporadic human cerebral small vessel disease: A systematic review

Correlations in post‐mortem imaging‐histopathology studies of sporadic human cerebral small vessel disease: A systematic review

Cerebral microbleeds: Beyond the macroscope

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