Comparative analysis of connective tissue disease–associated interstitial lung disease and interstitial pneumonia with autoimmune features

Tian, Ming; Huang, Wenhan; Ren, Feifeng; Luo, Lei; Zhou, Jun; Huang, Dongmei; Tang, Lin

doi:10.1007/s10067-019-04836-3

Cited by 26 publications

(23 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The incidence of joint pain in patients with CTD-ILD was higher than in the patients with IPF in our study, which was in line with the previous studies [36]. It was reported that the prevalence of joint pain in CTD-ILD patients could be explained by the high anti-cyclic citrullinated peptide antibody (anti-CCP) positivity in patients [37]. ILD Group experienced a higher pain intensity than HC Group both in feeling and emotion dimension.…”

Section: Discussionsupporting

confidence: 91%

Pain is a common problem in patients with ILD

et al. 2020

View full text Add to dashboard Cite

Background As it is less known about the prevalence and characteristics of pain in the patients with interstitial lung disease (ILD), this paper aims at determining the characteristics of the pain in the patients with ILD. Methods Subjects with ILD and health controls with the matched ages and genders completed Short Form McGill Pain Questionnaire (SF-MPQ) and part of the Brief Pain Inventory (BPI) Short Form to elicit the characteristics of the pain. The patients with ILD were also assessed through Pulmonary Function Test, Six Minutes Walking Test (6MWT), modified Medical Research Council Dyspnea Scale (mMRC) for state of the illness and measured health-related quality of life (HRQoL) by Short Form-36 (SF-36) and psychological associations by Hospital Anxiety and Depression Scale (HADS). Results A total of 63 subjects with ILD and 63 healthy controls (HC) were recruited in our study. The prevalence of the pain was 61.9% in ILD versus 25.3% in HC (P = 0.005) and the median score of the pain rank index (PRI) in ILD was higher than that in HC (P = 0.014). Chest (46.1%) accounted for the highest of overall pain locations in subjects with ILD. Associated clinical factors for pain intensity in the patients with ILD included exposure history of risk factors of ILD, with a longer distance of 6MWD (≥ 250 m), and a higher mMRC score (2–4). The patients with ILD and pain are more likely to suffer impaired HRQoL (P = 0.0014) and psychological problems (P = 0.0017, P = 0.044). Conclusion The pain is common in those with ILD and the pain intensity is associated with exposure history, 6MWD, and mMRC score. The patients with ILD and pain were possibly to suffer depression, anxiety, and impaired HRQoL.

show abstract

Section: Discussionsupporting

confidence: 91%

Pain is a common problem in patients with ILD

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The incidence of joint pain in patients with CTD-ILD was higher than patients with IPF in our study, which was in line with the previous studies (33). It was reported that the prevalence of joint pain in CTD-ILD patients could be explained by the high anti-cyclic citrullinated peptide antibody (anti-CCP) positivity in patients (34). Further studies with larger sample sizes are required to con rm these ndings.…”

Section: Discussionsupporting

confidence: 92%

Pain is a common problem in patients with ILD

Shen

Guo

Song

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Less is known about the prevalence and characteristics of pain in interstitial lung disease (ILD) patients.To determine the characteristics of pain in ILD patients. Methods Participants with ILD and age, gender-matched, healthy controls completed short form McGill Pain Questionnaire (SF-MPQ) and part of the Brief Pain Inventory short form(BPI) to elicit pain characteristics. ILD patients also had assessments of pulmonary function test, six minutes walking test (6MWT), modified medical research council dyspnea scale (mMRC) for state of the illness and measured health-related quality of life(HRQoL) by short form-36(SF-36)and psychological associations by hospital anxiety and depression scale(HADS). Results A total of 63 participants with ILD and 63 healthy controls(HC) were recruited in our study. The prevalence of pain was 61.9% in ILDs versus 25.3% in HC (p=0.005) and the median score of pain rank index (PRI) in ILDs was higher than in HC (P=0.014). Chest(46.1%) accounted for the highest of overall pain locations in participants with ILD. Associated clinical factors for pain intensity in ILD patients included younger age (<60 years), exposure history of ILD risk factors, longer distance of 6MWD(≥250m), higher mMRC score(2-4) and lower DLCo, % predicted(≤45%). ILD patients with pain are more likely to suffer impaired HRQoL(P=0.0014) and psychological problems(P=0.0017,P=0.044). Conclusion Pain is common in those with ILD and the pain intensity is associated with age, exposure history, 6MWD, mMRC score and DLCo, % predicted. ILD patients with pain have more possible to suffer depression, anxiety and impaired HRQoL.

show abstract

“…A r t i c l e some reports showed an UIP dominance in IPAF, which was found in 27.9% to 44.2% of cases [12,16,19,20].…”

Section: A C C E P T E Dmentioning

confidence: 94%

“…Among the 3 domains of the IPAF classification criteria, the morphological domain is the most frequently fulfilled domain (78.9-100%), followed by the serological and clinical domains accounting for 48.9-93.0% and 31.5-62.2% of cases, respectively [7][8][9][10]15,17,21]. The common findings in the clinical domain are Raynaud's phenomenon (8.89-74.1%), mechanic's hands (4-29%), inflammatory arthritis/morning stiffness (16-76.5%), and Gottron's sign (5-18%) [7][8][9][10][15][16][17]19]. In the serological domain, antinuclear antibody (ANA) titers higher than 1:320 in diffuse, speckled, homogeneous patterns or any titer for nucleolar or centromere is the most frequent finding (10.3-82.4%), followed by rheumatoid factor (4.4-28.6%), anti-Ro (4.4-55.9%), and anti-tRNA synthetase positivities (0-35.7%) [7][8][9][10][15][16][17]19].…”

Section: A C C E P T E Dmentioning

confidence: 99%

“…ILD is a relatively common pulmonary manifestation in various ARDs such as systemic sclerosis (SSc), inflammatory myositis, primary Sjongren's syndrome (pSS), and rheumatoid arthritis (RA). The highest incidence of ILD in ARDs is found in patients with SSc (43.0-91.0%) [22][23][24], followed by those with inflammatory myositis (19.9-78%) [25][26][27], RA (7.7-33.0%) [28,29], and pSS (8.0-39.1%) [30][31][32] ILD, formerly CTD-ILD), the SSc-specific autoantibody, anti-topoisomerase (Scl-70), is not predominantly present in the IPAF group (0-5.7%) [7][8][9][10]15,17,19]. However, in the serological domain, ANA positivity in the IPAF classification criteria includes that in any titer with a nucleolar or centromere pattern, which is the typical pattern of limited cutaneous SSc [33].…”

Section: Comparison Between Ipaf and Ard-ildmentioning

confidence: 99%

See 1 more Smart Citation

Recent advances in the diagnosis and management of interstitial pneumonia with autoimmune features: the perspective of rheumatologists

Min

Kim

Lee

et al. 2021

Korean J Intern Med

View full text Add to dashboard Cite

Interstitial pneumonia with autoimmune features (IPAF) is a recently established disease entity that is comprised of interstitial lung diseases with evidence of autoimmune features but does not fulfill the criteria for definite autoimmune rheumatic disease. The classification criteria for IPAF were defined by the European Respiratory Society and American Thoracic Society in 2015. However, for these classification criteria, further studies to establish IPAF subgroups and treatment modalities for each subgroup are still needed. In this review, we discuss the recent advances in the field of IPAF and raise critical points for the diagnosis and management of patients with IPAF from the perspective of rheumatologists.

show abstract

Comparative analysis of connective tissue disease–associated interstitial lung disease and interstitial pneumonia with autoimmune features

Cited by 26 publications

References 44 publications

Pain is a common problem in patients with ILD

Pain is a common problem in patients with ILD

Pain is a common problem in patients with ILD

Recent advances in the diagnosis and management of interstitial pneumonia with autoimmune features: the perspective of rheumatologists

Contact Info

Product

Resources

About