Comparative analysis of cobalt ferrite and iron oxide nanoparticles using bimodal hyperthermia, along with physical and in silico interaction with human hemoglobin

Abstract

Magnetic nanoparticles (MNPs) have captivated the scientific community towards biomedical applications owing to their numerous distinctive physio-chemical properties. In this work, Cobalt ferrite (CFNPs) and Iron oxide nanoparticles (IONPs) were...

Biophysical and computational analyses of interaction of 2D MoS2 nanosheets with human haemoglobin coupled with NIR activated photothermal therapy

“…45 There are several tryptophan residues in Hb but β-37 Trp is the most prevalent fluorophore, which provides a good understanding of drug–protein binding. 20,46 Native haemoglobin shows a sharp emission band at 333 nm when excited at 280 nm, as shown in Fig. 8.…”

“…The peak at 270 nm is attributed to π → π* transition of aromatic amino acid residues (Tyr, Trp, and Phe). 20,41 Furthermore, a peak at 410 nm is observed and is commonly referred to as the Soret band, which serves as a distinctive feature of the heme protein. This peak corresponds to the d–π* transition between the heme complex and the iron ion in Hb.…”

“…Conversely, in dynamic quenching, K sv shows a direct relationship with temperature as higher temperature results in a higher diffusion rate of quencher with a large number of collisions between the quencher and fluorophore. 20…”

“…17,18 PTT is a minimally invasive technique that uses NIR laser to irradiate nanoprobes, resulting in heat generation for the localized destruction of malignant tissues. 19–21 The photothermal therapeutic agent and NIR laser are the two significant prerequisites for PTT. When exposed to laser light, the nanoparticles absorb NIR light causing hyperthermia leading to apoptotic cell death.…”

Employing Spectroscopic, Electrochemical, and In Silico Research to Investigate the Interaction of Ofloxacin, Antibacterial Drug With the Haemoglobin

“…Understanding the interactions between Hb and ofloxacin as well as conformational rearrangements in the Hb can be understood by UV‐visible spectroscopy [27] . Within the 200–500 nm wavelength range, Hb exhibits three distinct absorption peaks (212, 274 and 406 nm) [28–36] . Figure 1 illustrates an increase in Hb absorption intensity at 278 nm and an insignificant change at 406 nm with a gradual increase in concentration of ofloxacin.…”