Comparative analysis of amniotic fluid lamellar body count and foam stability test as indices of fetal lung maturity

Abstract

Although both tests are good in predicting the fetal lung maturity, the lamellar body count has more advantages, because it is not only more objective, but also inexpensive, easy and fast to do, requires a small sample volume and is universally available.

Application of axisymmetric drop shape analysis and brewster angle microscopy for assessment of clinical samples from prematurely born infants with NRDS

“…So far, the prediction and diagnostics of the lung immaturity is achieved by assessment of clinical parameters and laboratory analyses of the alveolar surfactant in amniotic fluid from pregnant women [5], or tracheal and nasopharyngeal aspirates from babies [6][7][8]. Nowadays, the most popular and employed biochemical methods for surfactant maturity testing include determination of: protein/phospholipids [9], and lecithin/sphingomyelin ratios in clinical samples [10][11][12][13][14]; the number of the lamellar bodies in amniotic fluid [14][15][16][17]; the presence of specific surfactant proteins [18], etc. In addition, the most commonly used biophysical methods for surfactant maturity assessment are: black foam film method [19,20]; decreasing the surface tension of clinical samples extractions [21,22]; foam stability test [15,[23][24][25]; microbubbles stability test [26][27][28]; click-method for bubbles formation [29][30][31], etc.…”

Lamellar Body Count has Higher Sensitivity and Specificity in the Prediction of Neonatal Respiratory Distress Syndrome

“…But the number of cases of RDS in this study can be considered eligible for this study, because the incidence of RDS in this case as much as 15.3% was in line with the incidence of RDS in these studies were used as a reference in calculating the number of samples for this study ie 10.5% on research by Djanas et al, and 14.6% in the study Visnjevac et al 16 In this study, the results of foam test has sensitivity rate of 67% and specificity of 90%, slightly better when compared with the results of the study Visnjevac et al that resulted in a sensitivity rate 67.6% and specificity of 72.2% for the foam test. 16 In predicting the occurrence of RDS, the test foam is superior to ensure no RDS. It is shown from the value of negative predictive value that is much higher when compared to the value of the positive predictive value (94% to 55%).…”

Accuracy of Amniotic Fluid Lamellar Body Counting for Evaluating Fetal Lung Maturity

“…There are some tests for evaluating the fetal lung maturity with some advantages and disadvantages. For example, the ratio of sphingomyelin to lecithin is a traditional test for assessing the fetal lung maturity (2); but taking the long time to do, being costly, lack of widely access, and none ability to use when meconium or blood stained the amniotic fluid, are its disadvantages.…”