Comparative analysis between myocardial perfusion reserve and maximal ischemia score at single photon emission computed tomography with new-generation cadmium-zinc-telluride cameras

Nudi, Francesco; Biondi‐Zoccai, Giuseppe; Nudi, Alessandro; Neri, G; Procaccini, Enrica; Schilllaci, Orazio

doi:10.1007/s12350-019-01764-2

Cited by 6 publications

(5 citation statements)

References 20 publications

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“…In diagnosing an obstructive lesion in the corresponding artery, De Souza et al [57] found a regional MFR sensitivity of 63.2 % and specificity of 74.1 % with a cutoff of 2.2. In contrast, Nudi et al [65] discovered no link between MFR and significant obstruction in coronary arteries in CAG.…”

Section: Dynamic Czt-spect In Coronary Artery Diseasementioning

confidence: 91%

Myocardial perfusion imaging using single-photon emission computed tomography with cadmium-zinc-telluride technology

2022

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Myocardial perfusion imaging (MPI) with single-photon emission computed tomography (SPECT) is a well-established diagnostic approach for patients with suspected or confirmed coronary artery disease (CAD). In the present century, nuclear cardiology has benefited immensely from advances in imaging instrumentation and technology. Dedicated cardiac SPECT cameras incorporating novel, highly efficient cadmium-zinc-telluride (CZT) detectors, collimators, and system designs have evolved as a result of the expansion of nuclear cardiology. A vast amount of evidence is emerging, demonstrating the new technology's advantages over the traditional gamma cameras. Myocardial perfusion imaging (MPI) using gamma-cameras with CZT detectors may be performed with the limited injected activity of radiotracer and recorded times. The use of CZT's dynamic acquisition of myocardial perfusion imaging in clinical practice may help cardiologists in detecting hemodynamically significant CAD. In this article, we present the current state of knowledge on cardiac CZT-SPECT scanners, a summary of the literature published on validation studies, radiation dose reduction, and dynamic acquisition, as well as a comparison of conventional myocardial perfusion imaging with invasive coronary angiography.

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Section: Dynamic Czt-spect In Coronary Artery Diseasementioning

confidence: 91%

Myocardial perfusion imaging using single-photon emission computed tomography with cadmium-zinc-telluride technology

2022

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“…Another aspect of the processing protocol is the model used during kinetic analysis. Many studies of SPECT flow imaging have used a 1-tissue compartment model (1CM) 1,3,[5][6][7][8] as is most often used for PET imaging with 82 Rb, though other SPECT MBF studies 2,[9][10][11][12] have also successfully used a net retention model (RET). With the 1CM, three parameters (K 1 , DV, FBV) are fit non-linearly to a dynamic image series using equations 1 and 2.…”

Section: Introductionmentioning

confidence: 99%

Improved precision of SPECT myocardial blood flow using a net tracer retention model

et al. 2023

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Background: Noninvasive quantification of absolute myocardial blood flow (MBF) and myocardial flow reserve (MFR) provides incremental benefit to relative myocardial perfusion imaging (MPI) to diagnose and manage heart disease. MBF can be measured with single-photon emission computed tomography (SPECT) but the uncertainty in the measured values is high. Standardization and optimization of protocols for SPECT MBF measurements will improve the consistency of this technique. One element of the processing protocol is the choice of kinetic model used to analyze the dynamic image series. Purpose: This study evaluates if a net tracer retention model (RET) will provide a better fit to the acquired data and greater test-retest precision than a one-compartment model (1CM) for SPECT MBF, with (+MC) and without (-MC) manual motion correction. Methods: Data from previously acquired rest-stress MBF studies (31 SPECT-PET and 30 SPECT-SPECT) were reprocessed ± MC. Rate constants (K1) were extracted using 1CM and RET, +/-MC, and compared pairwise with standard PET MBF measurements using cross-validation to obtain calibration parameters for converting SPECT rate constants to MBF and to assess the goodness-of -fit of the calibration curves. Precision (coefficient of variation of test re-test relative differences, COV) of flow measurements was computed for 1CM and RET ± MC using data from the repeated SPECT MBF studies. Results: Both the RET model and MC improved the goodness-of -fit of the SPECT MBF calibration curves to PET. All models produced minimal bias compared with PET (mean bias < 0.6%). The SPECT-SPECT MBF COV significantly improved from 34% (1CM+MC) to 28% (RET+MC, P = 0.008). Conclusion:The RET+MC model provides a better calibration of SPECT to PET and blood flow measurements with better precision than the 1CM, without loss of accuracy. K E Y W O R D S myocardial blood flow (MBF), myocardial flow reserve (MFR), net tracer retention model, precision, SPECT, tissue compartment model

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“…In their study, Nudi et al tried to compare the different capabilities of qualitative and quantitative myocardial perfusion assessment in patients with suspected or known CAD submitted to CZT imaging, with a particular reference on patient characteristics, imaging diagnostic yield, and short-term patients' outcome. 15 To this purpose, a retrospective single-center evaluation of MPI data obtained with a dedicated cardiac CZT camera in 66 patients was performed. Patients underwent a single-day stress-rest CZT scan with sequential dynamic and static acquisitions and myocardial perfusion heterogeneity was evaluated both semiquantitatively and in absolute terms.…”

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confidence: 99%

MPI in the era of CZT cameras: Absolute numbers are still better than relative figures

Liga

Gimelli

2021

Journal of Nuclear Cardiology

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Comparative analysis between myocardial perfusion reserve and maximal ischemia score at single photon emission computed tomography with new-generation cadmium-zinc-telluride cameras

Cited by 6 publications

References 20 publications

Myocardial perfusion imaging using single-photon emission computed tomography with cadmium-zinc-telluride technology

Myocardial perfusion imaging using single-photon emission computed tomography with cadmium-zinc-telluride technology

Improved precision of SPECT myocardial blood flow using a net tracer retention model

MPI in the era of CZT cameras: Absolute numbers are still better than relative figures

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