Comparative acute oral toxicity ofpara-aminopropiophenone (PAPP) in mammals and birds

Savarie, Peter J.; Pan, Huo Ping; Hayes, D. K.; Roberts, Jerry D.; Dasch, Gary J.; Felton, Robert; Schafer, Edward W.

doi:10.1007/bf01610109

Cited by 48 publications

(39 citation statements)

References 6 publications

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“…As shown, there are marked differences in the PAPP LD5 0 values, which varied with strain, species (43,78), sex (18), and route of administration (79). These variations in the LD 50 may be explained by differences in the rate of microsomal metabolism of PAPP to the active compound, PHAPP, and/or the MetHb reductase activity (89).…”

Section: Genotoxicity and Mutagenicity Testsmentioning

confidence: 94%

The Pharmacology of p‐Aminopropiophenone in the Detoxification of Cyanide

Baskin

Fricke

1992

Cardiovascular Drug Reviews

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Section: Genotoxicity and Mutagenicity Testsmentioning

confidence: 94%

The Pharmacology of p‐Aminopropiophenone in the Detoxification of Cyanide

Baskin

Fricke

1992

Cardiovascular Drug Reviews

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“…Mammalian carnivores appear generally more susceptible to oral doses of the aryl amine compound p-aminopropriophenone (PAPP) than either rodents or birds (Table 1) as found by Savarie et al (1983) in an investigation of PAPP as a potentially selective coyote (Canis latrans) toxicant. Currently there is renewed interest in its potential as a toxicant for the management of introduced pest predators such as feral cats (Felis catus; Australian Pesticides & Veterinary Medicines Authority 2006 www.apvma.gov.au/chemrev/ 1080_faq.shtml) and canids (Vulpes vulpes, Canis familiaris) in Australia (Marks et al, 2004;Fleming et al, 2006) and stoats (Mustela erminea; and ferrets (Mustela furo) in New Zealand (Fisher and O'Connor, 2007).…”

Section: Introductionmentioning

confidence: 98%

ORAL TOXICITY OF p-AMINOPROPIOPHENONE TO BRUSHTAIL POSSUMS (TRICHOSURUS VULPECULA), DAMA WALLABIES (MACROPUS EUGENII), AND MALLARDS (ANAS PLATYRHYNCHOS)

Fisher¹,

O'Connor²,

Morriss³

2008

Journal of Wildlife Diseases

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ABSTRACT:Development of p-aminopropiophenone (PAPP) as a toxicant for pest predator management in New Zealand and Australia prompted investigation of its toxicity to potential nontarget species. Acute oral toxicity of PAPP in brushtail possums (Trichosurus vulpecula), dama wallabies (Macropus eugenii), and Mallards (Anas platyrhynchos) was estimated in pen trials, ) were more susceptible than other bird species. These results suggest that the nontarget hazard to possums and wallabies from PAPP bait applied for pest predator control would be low. However, future development of PAPP as a vertebrate pest control agent should include rigorous assessments of the hazard posed by bait formulations to bird species and provision for delivery techniques that could mitigate exposure of nontarget birds.

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“…Toxicity studies established that mammalian carnivores were particularly susceptible to PAPP, leading to investigations as a toxin to control coyotes (Canis latrans) in the USA (Savarie et al 1983;Eason et al 2014). In Australia, development of PAPP over the last decade or so has focussed on applications to target feral cats (Felis catus), European red foxes (Vulpes vulpes) and wild dogs (Fleming et al 2014;Marks et al 2004).…”

Section: Introductionmentioning

confidence: 99%

The longevity of para-aminopropiophenone (PAPP) wild dog baits and the implications for effective and safe baiting campaigns

Gentle¹,

Speed²,

Allen

et al. 2017

Environ Sci Pollut Res

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Considerable effort goes into mitigating the impacts caused by invasive animals and prohibiting their establishment or expansion. In Australia, management of wild dogs (Canis lupus dingo and their hybrids) and their devastating impacts is reliant upon poison baiting. The recent release of baits containing the humane toxin para-aminopropiophenone (PAPP) offers potential improvements for control of wild dogs, but little is known about the environmental persistence of PAPP in manufactured baits that could be used to inform best practice guidelines. We investigated the degradation rate of PAPP wild dog baits (DOGABAIT™) under typical field usage and storage conditions in north-eastern Australia and calculated optimal deployment and withholding periods. The PAPP content of buried baits declines faster than surface-laid baits, but both presentations retained lethal doses to wild and domestic dogs for considerable periods (6-16 weeks). Domestic or working dogs should be suitably restrained or excluded from baited areas for extended periods, particularly under dry conditions, to minimise poisoning risk. The period of persistence of PAPP baits may provide opportunities to improve the duration or longer term efficacy of baiting campaigns, but care is needed to protect domestic and working dogs to ensure responsible and safe use.

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Comparative acute oral toxicity ofpara-aminopropiophenone (PAPP) in mammals and birds

Cited by 48 publications

References 6 publications

The Pharmacology of p‐Aminopropiophenone in the Detoxification of Cyanide

The Pharmacology of p‐Aminopropiophenone in the Detoxification of Cyanide

ORAL TOXICITY OF p-AMINOPROPIOPHENONE TO BRUSHTAIL POSSUMS (TRICHOSURUS VULPECULA), DAMA WALLABIES (MACROPUS EUGENII), AND MALLARDS (ANAS PLATYRHYNCHOS)

The longevity of para-aminopropiophenone (PAPP) wild dog baits and the implications for effective and safe baiting campaigns

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