The Pharmacology of <i>p</i>‐Aminopropiophenone in the Detoxification of Cyanide

Baskin, Steven I.; Fricke, Robert F.

doi:10.1111/j.1527-3466.1992.tb00256.x

Cited by 18 publications

(14 citation statements)

References 53 publications

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“…PAPP was originally synthesised in 1900, and initial research focussed on investigation as an antidote to cyanide poisoning in humans (Baskin and Fricke 1992). Toxicity studies established that mammalian carnivores were particularly susceptible to PAPP, leading to investigations as a toxin to control coyotes (Canis latrans) in the USA (Savarie et al 1983;Eason et al 2014).…”

Section: Introductionmentioning

confidence: 99%

The longevity of para-aminopropiophenone (PAPP) wild dog baits and the implications for effective and safe baiting campaigns

Gentle¹,

Speed²,

Allen

et al. 2017

Environ Sci Pollut Res

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Considerable effort goes into mitigating the impacts caused by invasive animals and prohibiting their establishment or expansion. In Australia, management of wild dogs (Canis lupus dingo and their hybrids) and their devastating impacts is reliant upon poison baiting. The recent release of baits containing the humane toxin para-aminopropiophenone (PAPP) offers potential improvements for control of wild dogs, but little is known about the environmental persistence of PAPP in manufactured baits that could be used to inform best practice guidelines. We investigated the degradation rate of PAPP wild dog baits (DOGABAIT™) under typical field usage and storage conditions in north-eastern Australia and calculated optimal deployment and withholding periods. The PAPP content of buried baits declines faster than surface-laid baits, but both presentations retained lethal doses to wild and domestic dogs for considerable periods (6-16 weeks). Domestic or working dogs should be suitably restrained or excluded from baited areas for extended periods, particularly under dry conditions, to minimise poisoning risk. The period of persistence of PAPP baits may provide opportunities to improve the duration or longer term efficacy of baiting campaigns, but care is needed to protect domestic and working dogs to ensure responsible and safe use.

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Section: Introductionmentioning

confidence: 99%

The longevity of para-aminopropiophenone (PAPP) wild dog baits and the implications for effective and safe baiting campaigns

Gentle¹,

Speed²,

Allen

et al. 2017

Environ Sci Pollut Res

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show abstract

“…Methemoglobin (MHb) formation is an effective strategy to counter cyanide (CN) toxicity [1][2][3][4]. An 8-aminoquinoline, 8-[(4-amino-l-methylbutyl)amino]-5-(l-hexyloxy)-6-methoxy-4-methyl quinoline (DL-tartrate), hereafter referred to as WR242511 (Figure 1), was initially studied for its potent antimalarial properties.…”

Section: Introductionmentioning

confidence: 99%

Toxicity in rhesus monkeys following administration of the 8-aminoquinoline 8-[(4-amino-l-methylbutyl)amino]-5-(l-hexyloxy)-6-methoxy-4-methylquinoline (WR242511)

et al. 2008

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Introduction: Many substances that form methemoglobin (MHb) effectively counter cyanide (CN) toxicity. Although MHb formers are generally applied as treatments for CN poisoning, it has been proposed that a stable, long-acting MHb former could serve as a CN pretreatment. Using this rationale, the 8-aminoquinoline WR242511, a potent long-lasting MHb former in rodents and beagle dogs, was studied in the rhesus monkey for advanced development as a potential CN pretreatment.Methods: In this study, WR242511 was administered intravenously (IV) in 2 female and 4 male rhesus monkeys in doses of 3.5 and/or 7.0 mg/kg; a single male also received WR242511 orally (PO) at 7.0 mg/kg. Health status and MHb levels were monitored following exposure.Results: The selected doses of WR242511, which produced significant methemoglobinemia in beagle dogs in earlier studies conducted elsewhere, produced very little MHb (mean Ͻ2.0%) in the rhesus monkey. Furthermore, transient hemoglobinuria was noted approximately 60 minutes postinjection of WR242511 (3.5 or 7.0 mg/kg), and 2 lethalities occurred (one IV and one PO) following the 7.0 mg/kg dose. Myoglobinuria was also observed following the 7.0 mg/kg dose. Histopathology analyses in the 2 animals that died revealed liver and kidney toxicity, with greater severity in the orally-treated animal.Conclusions: These data demonstrate direct and/or indirect drug-induced toxicity. It is concluded that WR242511 should not be pursued as a pretreatment for CN poisoning unless the anti-CN characteristics of this compound can be successfully dissociated from those producing undesirable toxicity.

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“…A n t i -c y a n i d e t h e r a p y m a y b e a c u t e , s u c h a s i n p o i s o n i n g s , o r prophylactic, as in military applications where a longer duration of action is required (Baskin and Fricke, 1992). Cyanide detoxification occurs in vivo mainly by conversion to thiocyanate.…”

Section: Antidotes and Cyanide Treatmentsmentioning

confidence: 99%

Modification by Aqueous Extracts of Allium kurrat L. and Ricinus communis L. of Cyanide Nephrotoxicity on Balb/C Mice

Elsaid¹

2012

Oxidative Stress - Environmental Induction and Dietary Antioxidants

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The Pharmacology of p‐Aminopropiophenone in the Detoxification of Cyanide

Cited by 18 publications

References 53 publications

The longevity of para-aminopropiophenone (PAPP) wild dog baits and the implications for effective and safe baiting campaigns

The longevity of para-aminopropiophenone (PAPP) wild dog baits and the implications for effective and safe baiting campaigns

Toxicity in rhesus monkeys following administration of the 8-aminoquinoline 8-[(4-amino-l-methylbutyl)amino]-5-(l-hexyloxy)-6-methoxy-4-methylquinoline (WR242511)

Modification by Aqueous Extracts of Allium kurrat L. and Ricinus communis L. of Cyanide Nephrotoxicity on Balb/C Mice

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