Comparative actionof fenfluramine on the uptake and release of serotonin and dopamine

Studies on brain metabolism of biogenic amines.

“…The decrease of 5-HT in rat brain induced by fenfluramine is antagonized by chlorimipramine but not by nomifensine (Figure 4). Fenfluramine produces a long-lasting depletion of brain 5-HT by promoting the release of 5-HT from its storage sites (Fuxe et aL, 1975;Kannengiesser et al, 1976). Since the 5-HTdepleting action of fenfluramine is antagonized by pretreatment with strong 5-HT uptake blockers, like chlorimipramine (Ghezzi et al, 1973), fenfluramine probably uses the membrane-bound amine uptake system ('membrane pump') to enter the 5-HT neurones.…”

MDMA (Ecstasy) Inhibition of MAO Type A and Type B: Comparisons with Fenfluramine and Fluoxetine (Prozac)

“…Both drugs bind to the sero tonin transporter, with a similar affinity (Poblete et al 1989). MDMA and FEN both release serotonin (E.C.so = 2.92 and 7.90 IlmollL, respectively, Berger et al 1992;Borroni et al 1983;Buczko et al 1975;Johnson et al 1986;Kannengiesser et al 1976;Schmidt et al 1987), with FEN being more potent. In contrast, MDMA ap pears to be slightly more potent than FEN at inhibition of reuptake (0.42 IlmollL, Steele et al 1987 and0.876 IlmollL, Borroni et al 1983, respectively).…”

Blockage of progesterone-induced release of luteinizing hormone and prolactin byd-amphetamine and fenfluramine in rats

“…Fenfluramine also affects central serotonin-and noradrenaline-containing systems (Calderini et al, 1975). These different actions on brain monoamines might be dose-related (Kannengiesser et al, 1976). Therefore, in order to clarify the inhibitory effect on progesterone action, experiments employing other doses of fenfluramine remain to be performed.…”