Comparability of the age and sex distribution of the UK Clinical Practice Research Datalink and the total Dutch population

Jong, Roy G.P.J. de; Gallagher, Arlene M.; Herrett, Emily; Masclee, Ad; Janssen‐Heijnen, M.L.G.; Vries, Frank de

doi:10.1002/pds.4074

Cited by 9 publications

(9 citation statements)

References 14 publications

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“…Since 1987, the CPRD has recorded data such as patient demographics, medical history, laboratory test results, medical diagnosis and prescription details [13]. The CPRD has been extensively used and validated for pharmacoepidemiological and epidemiological research, and has been shown to be representative for populations outside the UK [13,14]. The protocol for this study was approved by the Independent Scientific Advisory Committee for Medicines and Healthcare products Regulatory Agency (MHRA) Database research ( protocol 18_107).…”

Section: Methodsmentioning

confidence: 99%

The risk of community-acquired pneumonia in children using gastric acid suppressants

et al. 2021

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With the increased use of acid suppressants, significant potential complications, such as community-acquired pneumonia are becoming more apparent. Paradoxically, in spite of an increased focus on potential complications, there is an increased use of acid suppressants in children and a lack of data specifically targeting the association between acid suppressants and community-acquired pneumonia. Our main objective was to evaluate the risk of community-acquired pneumonia in children using acid suppressants (proton pump inhibitors and/or histamine-2-receptor antagonists).We performed a cohort study using data from the Clinical Practice Research Datalink. All patients aged 1 month to 18 years with a prescription of acid suppressants were included and matched to up to 4 unexposed children. Time-varying Cox proportional hazards models were used to estimate the risk of community-acquired pneumonia. The cohort consisted of 84 868 exposed and 325 329 unexposed children.Current use of proton pump inhibitors and histamine-2-receptor antagonists was associated with an increased risk of community acquired pneumonia, adjusted hazard ratio 2.05 (95% CI 1.90 to 2.22) and 1.80 (95% CI 1.67 to 1.94), respectively. The risk was even greater in patients with respiratory disease. Long term use >211 days of proton pump inhibitors and histamine-2-receptor antagonists led to a significantly greater risk of community-acquired pneumonia compared to short term use <31 days. After cessation of therapy, the risk remained increased for the following 7 months.The use of acid suppressants in children was associated with a doubled risk of community-acquired pneumonia. This risk increased with chronic use, respiratory disease and remained increased after discontinuation of therapy.

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Section: Methodsmentioning

confidence: 99%

The risk of community-acquired pneumonia in children using gastric acid suppressants

et al. 2021

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“…In patients without diagnosed HF or isolated loop-diuretic use at AF diagnosis, the crude incidence of HF or new isolated loop-diuretic use was calculated from the number of new cases divided by the sum of all individual person-years in the cohort. Standardised incidence rates were computed based on the age and gender distribution of the UK population in CPRD in 2011 [ 13 ]. The Aalen-Johansen estimator was used to compute overall and gender-stratified cumulative incidence curves for diagnosed HF and isolated loop-diuretic use, and death before HF as competing risks.…”

Section: Methodsmentioning

confidence: 99%

Under-recognition of heart failure in patients with atrial fibrillation and the impact of gender: a UK population-based cohort study

Zakeri

Morgan

Sundaram

et al. 2021

BMC Med

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Background Patients with atrial fibrillation (AF) complicated by heart failure (HF) have a poor prognosis. We investigated whether long term loop-diuretic therapy in patients with AF and no known diagnosis of HF, as a potential surrogate marker of undiagnosed HF, is also associated with worse outcomes. Methods Adults with incident AF were identified from UK primary and secondary care records between 2004 and 2016. Repeat prescriptions for loop diuretics, without a diagnosis of HF or documented non-cardiac indication, were classified as ‘isolated’ loop diuretic use. Results Amongst 124,256 people with incident AF (median 76 years, 47% women), 22,001 (17.7%) had a diagnosis of HF, and 22,325 (18.0%) had isolated loop diuretic use. During 2.9 (LQ-UQ 1–6) years’ follow-up, 12,182 patients were diagnosed with HF (incidence rate 3.2 [95% CI 3.1–3.3]/100 person-years). Of these, 3999 (32.8%) had prior isolated loop diuretic use, including 31% of patients diagnosed with HF following an emergency hospitalisation. The median time from AF to HF diagnosis was 3.6 (1.2–7.7) years in men versus 5.1 (1.8–9.9) years in women (p = 0.0001). In adjusted models, patients with isolated loop diuretic use had higher mortality (HR 1.42 [95% CI 1.37–1.47], p < 0.0005) and risk of HF hospitalisation (HR 1.60 [95% CI 1.42–1.80], p < 0.0005) than patients with no HF or loop diuretic use, and comparably poor survival to patients with diagnosed HF. Conclusions Loop diuretics are commonly prescribed to patients with AF and may indicate increased cardiovascular risk. Targeted evaluation of these patients may allow earlier HF diagnosis, timely intervention, and better outcomes, particularly amongst women with AF, in whom HF appears to be under-recognised and diagnosed later than in men.

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“…A population-based cohort study was performed using the CPRD. The CPRD collates the computerized medical records of general practitioners (GPs) [17,18]. The data recorded in the CPRD include demographic information, prescription details, clinical events, preventive care provided, specialist referrals, and hospital admissions.…”

Section: Data Sourcementioning

confidence: 99%

Impact of the definition of osteoarthritis and of the timing of its onset on the association between type 2 diabetes mellitus and osteoarthritis: Clinical Practice Research Datalink

Nielen

Dagnelie

Boonen

et al. 2019

Diabetes Research and Clinical Practice

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Comparability of the age and sex distribution of the UK Clinical Practice Research Datalink and the total Dutch population

Cited by 9 publications

References 14 publications

The risk of community-acquired pneumonia in children using gastric acid suppressants

The risk of community-acquired pneumonia in children using gastric acid suppressants

Under-recognition of heart failure in patients with atrial fibrillation and the impact of gender: a UK population-based cohort study

Impact of the definition of osteoarthritis and of the timing of its onset on the association between type 2 diabetes mellitus and osteoarthritis: Clinical Practice Research Datalink

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