Impact of the definition of osteoarthritis and of the timing of its onset on the association between type 2 diabetes mellitus and osteoarthritis: Clinical Practice Research Datalink

Nielen, Johannes T H; Dagnelie, Pieter C.; Boonen, Annelies; Klungel, Olaf H.; Bemt, Bart van den; Vries, Frank de

doi:10.1016/j.diabres.2019.01.021

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…6 When using electronic healthcare data, variations in the number of OA cases identified can also result from the use of surgical or diagnostic proxies for OA diagnoses. 14,15 Our incidence figures for any OA in the general population are, however, in line with those from a UK-based study looking at the consultation incidence of OA using data from the Consultations in Primary Care Archive for a region of England. 16 Our prevalence figures in the general population are in line with a recent study using CPRD data by Swain, et al, but our incidence figures were higher than those reported in the same paper.…”

Section: Discussionsupporting

confidence: 81%

Risk of Osteoarthritis in an Incident Cohort of People With Psoriatic Arthritis: A Population-based Cohort Study

et al. 2020

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Objective To determine the risk of a diagnosis of osteoarthritis (OA) in psoriatic arthritis (PsA) patients compared to patients with psoriasis and a general population cohort. Methods Incident PsA patients aged 18-89 years at diagnosis were identified from the UK Clinical Practice Research Datalink between 1998 and 2014. All PsA patients were matched to two cohorts of patients both at a 1:4 ratio. The first cohort included patients with psoriasis (and no PsA) and the second was a general population cohort (with no psoriasis or PsA). The baseline prevalence of OA was calculated for each study cohort. The incidence of OA was calculated and adjusted relative risks (RRadj) were calculated using conditional Poisson regression. Results We identified 6,783 incident PsA patients. The baseline prevalence of OA ranged from 22.1% (CI9521.1-23.1) in the PsA cohort to 12.6% (CI9512.2-13.0) and 11.0% (CI9510.6- 11.3) in the psoriasis and general population cohorts respectively. The incidence of OA was significantly higher in the PsA cohort compared to the psoriasis and general population cohorts after adjusting for BMI (RRadj 1.68 CI951.46-1.93 and RRadj 1.86 CI951.62-2.14 respectively). Conclusion An increased risk of OA was observed in patients with PsA compared to patients with psoriasis alone and those in the general population. Further work is needed to determine whether this reflects a true increase in OA risk or misdiagnosed PsA and the extent to which it can be explained by differences in the opportunity for OA diagnosis between cohorts.

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Section: Discussionsupporting

confidence: 81%

Risk of Osteoarthritis in an Incident Cohort of People With Psoriatic Arthritis: A Population-based Cohort Study

et al. 2020

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“…Recent reviews 25,26 and a consensus-based framework 27 all highlight the very large 'problem space' within which OA phenotyping must take place and emphasise the value of rigorous empirically derived and validated approaches to phenotyping. Evaluating the sensitivity of exposureoutcome associations to phenotype choice and definition, perhaps especially in EHR datasets, will often contribute to this effort (e.g., 28 .…”

Section: The Elaboration Of Causesmentioning

confidence: 99%

Osteoarthritis year in review 2020: epidemiology & therapy

Peat

Thomas

2021

Osteoarthritis and Cartilage

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The association between ADAMTS14/rs4747096 gene polymorphism and some risk factors and knee osteoarthritis

Elshaarawy,

Salama,

Salama

et al. 2024

Preprint

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Aim To examine the connection between SNPs of ADAMTS14 gene rs4747096 and KOA and to assess risk factors associated with KOA. Methods A case control study was conducted on 158 patients with KOA and 120 controls with comparable age and sex randomly recruited from National Research Centre employees. All participants were subjected to full history taking, assessment of KOA severity using WOMAC scoring system, and thorough clinical examination. Blood sample was collected for detection of ADAMTS14/rs4747096 gene polymorphism. Results The frequency of ADAMTS14 gene rs4747096 genotypes among patients with KOA was for AA 73.5%, AG 25.7% and GG 0.7% compared to controls 963%, 31.3% and 5.6% respectively and the frequency of alleles among patients was for A 86.4% and G 78.7% compared to controls (78.7% and 21.3% respectively, P < 0.05. The study found that the median levels of total WOMAC score and its domains were significantly higher among KOA patients than controls. The logistic regression analysis revealed that older age, BMI ≥ 35, long standing at work, and severe physical exercise were predictive factors for KOA (P < 0.01). Conclusion For ADAMTS14 rs4747096 genotype, the AA and AG genotypes significantly increased the risk of KOA. Older age, females, morbid obesity, prolonged standing at work, and severe physical exercise were risk factors for KOA. Further studies are encouraged to investigate the mechanism by which this genotype can affect the development of KOA.

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Impact of the definition of osteoarthritis and of the timing of its onset on the association between type 2 diabetes mellitus and osteoarthritis: Clinical Practice Research Datalink

Cited by 3 publications

References 20 publications

Risk of Osteoarthritis in an Incident Cohort of People With Psoriatic Arthritis: A Population-based Cohort Study

Risk of Osteoarthritis in an Incident Cohort of People With Psoriatic Arthritis: A Population-based Cohort Study

Osteoarthritis year in review 2020: epidemiology & therapy

The association between ADAMTS14/rs4747096 gene polymorphism and some risk factors and knee osteoarthritis

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